BR112022022408A2 - Síntese de intermediários de álcool vinílico - Google Patents

Síntese de intermediários de álcool vinílico

Info

Publication number
BR112022022408A2
BR112022022408A2 BR112022022408A BR112022022408A BR112022022408A2 BR 112022022408 A2 BR112022022408 A2 BR 112022022408A2 BR 112022022408 A BR112022022408 A BR 112022022408A BR 112022022408 A BR112022022408 A BR 112022022408A BR 112022022408 A2 BR112022022408 A2 BR 112022022408A2
Authority
BR
Brazil
Prior art keywords
synthesis
vinyl alcohol
alcohol intermediates
compound
intermediates
Prior art date
Application number
BR112022022408A
Other languages
English (en)
Inventor
P Farrell Robert
S Tedrow Jason
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of BR112022022408A2 publication Critical patent/BR112022022408A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SÍNTESE DE INTERMEDIÁRIOS DE ÁLCOOL VINÍLICO. São proporcionados aqui processos para sintetizar intermediários úteis na preparação de inibidores de Mcl-1. Em particular são proporcionados aqui processos para sintetizar o composto E, em que R1 é descrito aqui. O composto E pode ser útil na síntese do composto A1, ou um seu sal ou solvato, ou do composto A2 ou um seu sal ou solvato.
BR112022022408A 2020-05-06 2021-04-28 Síntese de intermediários de álcool vinílico BR112022022408A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063020888P 2020-05-06 2020-05-06
PCT/US2021/029526 WO2021225835A1 (en) 2020-05-06 2021-04-28 Synthesis of vinylic alcohol intermediates

Publications (1)

Publication Number Publication Date
BR112022022408A2 true BR112022022408A2 (pt) 2022-12-13

Family

ID=76076436

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022022408A BR112022022408A2 (pt) 2020-05-06 2021-04-28 Síntese de intermediários de álcool vinílico

Country Status (12)

Country Link
US (1) US20230136910A1 (pt)
EP (1) EP4146637A1 (pt)
JP (1) JP2023524261A (pt)
KR (1) KR20230006561A (pt)
CN (1) CN115461332A (pt)
AU (1) AU2021268573B2 (pt)
BR (1) BR112022022408A2 (pt)
CA (1) CA3181189A1 (pt)
CL (1) CL2022003053A1 (pt)
IL (1) IL297522A (pt)
MX (1) MX2022013872A (pt)
WO (1) WO2021225835A1 (pt)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2825536B1 (en) * 2012-03-14 2020-06-17 Merck Sharp & Dohme Corp. Bis-quarternary cinchona alkaloid salts as asymmetric phase transfer catalysts
JO3474B1 (ar) * 2014-08-29 2020-07-05 Amgen Inc مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1
US11306107B2 (en) * 2016-02-25 2022-04-19 Amgen Inc. Compounds that inhibit MCL-1 protein
JP6453507B2 (ja) * 2017-03-30 2019-01-16 アムジエン・インコーポレーテツド Ｍｃｌ−１タンパク質を阻害する化合物
EP3762393B1 (en) * 2018-03-05 2023-01-11 Amgen Inc. Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere mcl-1 protein antagonists

Also Published As

Publication number Publication date
CL2022003053A1 (es) 2023-07-07
KR20230006561A (ko) 2023-01-10
US20230136910A1 (en) 2023-05-04
EP4146637A1 (en) 2023-03-15
AU2021268573A1 (en) 2023-01-05
CN115461332A (zh) 2022-12-09
CA3181189A1 (en) 2021-11-11
MX2022013872A (es) 2022-11-30
JP2023524261A (ja) 2023-06-09
IL297522A (en) 2022-12-01
AU2021268573B2 (en) 2024-06-06
WO2021225835A1 (en) 2021-11-11

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