BR112022021077A2 - Anticorpos humanizados antifator bb de complemento e uso dos mesmos - Google Patents
Anticorpos humanizados antifator bb de complemento e uso dos mesmosInfo
- Publication number
- BR112022021077A2 BR112022021077A2 BR112022021077A BR112022021077A BR112022021077A2 BR 112022021077 A2 BR112022021077 A2 BR 112022021077A2 BR 112022021077 A BR112022021077 A BR 112022021077A BR 112022021077 A BR112022021077 A BR 112022021077A BR 112022021077 A2 BR112022021077 A2 BR 112022021077A2
- Authority
- BR
- Brazil
- Prior art keywords
- complement
- humanized antibodies
- factor
- antibodies
- factor humanized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
ANTICORPOS HUMANIZADOS ANTIFATOR BB DE COMPLEMENTO E USO DOS MESMOS. A presente invenção refere-se a anticorpos humanizados antifator Bb, métodos de produção dos anticorpos e métodos de uso dos anticorpos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063012590P | 2020-04-20 | 2020-04-20 | |
PCT/US2021/027981 WO2021216458A1 (en) | 2020-04-20 | 2021-04-19 | Humanized anti-complement factor bb antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022021077A2 true BR112022021077A2 (pt) | 2022-12-13 |
Family
ID=78221896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022021077A BR112022021077A2 (pt) | 2020-04-20 | 2021-04-19 | Anticorpos humanizados antifator bb de complemento e uso dos mesmos |
Country Status (14)
Country | Link |
---|---|
US (2) | US11242382B2 (pt) |
EP (1) | EP4139350A4 (pt) |
JP (1) | JP2023522102A (pt) |
KR (1) | KR20230004686A (pt) |
CN (1) | CN115702165A (pt) |
AR (1) | AR121881A1 (pt) |
AU (1) | AU2021261257A1 (pt) |
BR (1) | BR112022021077A2 (pt) |
CA (1) | CA3173325A1 (pt) |
CO (1) | CO2022014878A2 (pt) |
IL (1) | IL297444A (pt) |
MX (1) | MX2022013135A (pt) |
TW (1) | TW202140543A (pt) |
WO (1) | WO2021216458A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CR20180529A (es) | 2016-04-04 | 2019-03-21 | Bioverativ Usa Inc | Anticuerpos anti-factor bb del complemento y usos de estos referencia cruzada |
CA3173325A1 (en) | 2020-04-20 | 2021-10-28 | Graham Parry | Humanized anti-complement factor bb antibodies and uses thereof |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997034631A1 (en) | 1996-03-18 | 1997-09-25 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
WO1998023289A1 (en) | 1996-11-27 | 1998-06-04 | The General Hospital Corporation | MODULATION OF IgG BINDING TO FcRn |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
ES2649037T3 (es) | 2000-12-12 | 2018-01-09 | Medimmune, Llc | Moléculas con semividas prolongadas, composiciones y usos de las mismas |
CA2561531C (en) | 2004-02-10 | 2017-05-02 | The Regents Of The University Of Colorado | Inhibition of factor b, the alternative complement pathway and methods related thereto |
PL1737891T3 (pl) * | 2004-04-13 | 2013-08-30 | Hoffmann La Roche | Przeciwciała przeciw selektynie p |
KR20170002684A (ko) | 2005-11-04 | 2017-01-06 | 제넨테크, 인크. | 안질환 치료를 위한 보체 경로 억제제의 용도 |
NZ616992A (en) | 2005-12-20 | 2015-07-31 | Sbi Biotech Co Ltd | Anti-ilt7 antibody |
EP2195024B1 (en) | 2007-08-27 | 2016-10-05 | NovelMed Therapeutics, Inc. | Method of inhibiting complement activation with factor bb specific antibodies |
AU2008323939A1 (en) | 2007-11-08 | 2009-05-14 | Genentech, Inc. | Anti-factor B antibodies and their uses |
WO2009082624A2 (en) | 2007-12-10 | 2009-07-02 | Zymogenetics, Inc. | Antagonists of il-17a, il-17f, and il-23 and methods of using the same |
WO2011041391A1 (en) | 2009-09-29 | 2011-04-07 | Fraunhofer Usa, Inc. | Influenza hemagglutinin antibodies, compositions, and related methods |
CA2853719A1 (en) * | 2011-10-27 | 2013-05-02 | Nkt Therapeutics Inc. | Humanized antibodies to inkt |
RU2014138474A (ru) | 2012-02-24 | 2016-04-10 | СтемСентРкс, Инк. | Новые модуляторы и способы применения |
WO2013152020A1 (en) | 2012-04-03 | 2013-10-10 | Novelmed Therapeutics, Inc. | Humanized and chimeric anti-factor bb antibodies and uses thereof |
WO2014044793A2 (en) | 2012-09-20 | 2014-03-27 | Max-Delbrück-Centrum für Molekulare Medizin | Cd22-binding peptides |
RS63212B1 (sr) | 2012-11-02 | 2022-06-30 | Bioverativ Usa Inc | Antikomplementna c1s antitela i njihove primene |
US9968687B2 (en) | 2013-02-22 | 2018-05-15 | Abbvie Stemcentrx Llc | Anti-DLL3 antibody drug conjugates |
US9260527B2 (en) | 2013-03-15 | 2016-02-16 | Sdix, Llc | Anti-human CXCR4 antibodies and methods of making same |
US10035847B2 (en) | 2013-10-02 | 2018-07-31 | The Rockefeller University | Amyloid protofibril antibodies and methods of use thereof |
EP3110845A1 (en) | 2014-02-27 | 2017-01-04 | Allergan, Inc. | Complement factor bb antibodies |
US10513558B2 (en) * | 2015-07-13 | 2019-12-24 | Cytomx Therapeutics, Inc. | Anti-PD1 antibodies, activatable anti-PD1 antibodies, and methods of use thereof |
CR20180529A (es) | 2016-04-04 | 2019-03-21 | Bioverativ Usa Inc | Anticuerpos anti-factor bb del complemento y usos de estos referencia cruzada |
TWI773695B (zh) | 2016-10-12 | 2022-08-11 | 美商生物維瑞提夫美國公司 | 抗C1s抗體及其使用方法 |
CN111527105A (zh) | 2017-10-11 | 2020-08-11 | 美国比奥维拉迪维股份有限公司 | 诱导补体活性的方法 |
CA3173325A1 (en) | 2020-04-20 | 2021-10-28 | Graham Parry | Humanized anti-complement factor bb antibodies and uses thereof |
-
2021
- 2021-04-19 CA CA3173325A patent/CA3173325A1/en active Pending
- 2021-04-19 KR KR1020227040234A patent/KR20230004686A/ko active Search and Examination
- 2021-04-19 AU AU2021261257A patent/AU2021261257A1/en active Pending
- 2021-04-19 BR BR112022021077A patent/BR112022021077A2/pt unknown
- 2021-04-19 AR ARP210101045A patent/AR121881A1/es unknown
- 2021-04-19 JP JP2022563374A patent/JP2023522102A/ja active Pending
- 2021-04-19 CN CN202180041793.XA patent/CN115702165A/zh active Pending
- 2021-04-19 IL IL297444A patent/IL297444A/en unknown
- 2021-04-19 MX MX2022013135A patent/MX2022013135A/es unknown
- 2021-04-19 US US17/234,618 patent/US11242382B2/en active Active
- 2021-04-19 WO PCT/US2021/027981 patent/WO2021216458A1/en active Application Filing
- 2021-04-19 TW TW110113949A patent/TW202140543A/zh unknown
- 2021-04-19 EP EP21792554.4A patent/EP4139350A4/en active Pending
- 2021-12-21 US US17/557,318 patent/US11999780B2/en active Active
-
2022
- 2022-10-19 CO CONC2022/0014878A patent/CO2022014878A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
TW202140543A (zh) | 2021-11-01 |
CN115702165A (zh) | 2023-02-14 |
CA3173325A1 (en) | 2021-10-28 |
US11999780B2 (en) | 2024-06-04 |
AR121881A1 (es) | 2022-07-20 |
IL297444A (en) | 2022-12-01 |
MX2022013135A (es) | 2022-11-10 |
US20210332115A1 (en) | 2021-10-28 |
EP4139350A4 (en) | 2024-04-24 |
AU2021261257A1 (en) | 2022-12-22 |
EP4139350A1 (en) | 2023-03-01 |
US11242382B2 (en) | 2022-02-08 |
JP2023522102A (ja) | 2023-05-26 |
KR20230004686A (ko) | 2023-01-06 |
WO2021216458A1 (en) | 2021-10-28 |
CO2022014878A2 (es) | 2023-02-16 |
US20220213179A1 (en) | 2022-07-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2019009365A2 (es) | Anticuerpos anti-lag3 | |
CY1124771T1 (el) | Αντισωματα εναντι-σορτιλiνης και μεθοδοι χρησης αυτων | |
EA201791961A1 (ru) | Антитела, специфичные к cd47 и pd-l1 | |
BR112022011651A2 (pt) | Degradadores de irak e usos dos mesmos | |
EA201791527A1 (ru) | Биспецифические антитела против плазменного калликреина и фактора xii | |
ECSP19086810A (es) | Anticuerpos que se unen específicamente a pd-1 y métodos de uso | |
CY1122456T1 (el) | Μονοκλωνικα αντισωματα εναντιον παραγοντα 15 αυξησης και διαφοροποιησης (gdf-15), και χρησεις αυτων για θεραπευτικη αγωγη καρκινικης καχεξιας και καρκινου | |
MY186351A (en) | Multispecific antibodies | |
EA201791270A1 (ru) | Модифицированные april-связывающие антитела | |
BR112022021077A2 (pt) | Anticorpos humanizados antifator bb de complemento e uso dos mesmos | |
UY36942A (es) | Proteínas de unión a antígeno que activan el receptor de leptina | |
BR112019013468A8 (pt) | Anticorpos anti-hiv-1 amplamente neutralizante e métodos de uso dos mesmos | |
WO2020051333A8 (en) | Anti-avb8 antibodies and compositions and uses thereof | |
BR112021017801A2 (pt) | Anticorpos biespecíficos anti-vbeta17/anti-cd123 | |
BR112021020357A2 (pt) | Anticorpos anti-cd3 de alta afinidade e métodos para sua geração e uso | |
EA202092849A1 (ru) | Моноспецифические и мультиспецифические антитела к tmeff2 и их применение | |
CO2022004797A2 (es) | Anticuerpos anti-klk7, anticuerpos anti-klk5, anticuerpos multiespecíficos anti-klk5/klk7 y métodos de uso | |
UY37598A (es) | Anticuerpos miméticos de fgf21 y usos de los mismos | |
BR112022018678A2 (pt) | Degradadores de mdm2 e usos dos mesmos | |
UY39798A (es) | Anticuerpos anti-ccr8 y usos de los mismos | |
CO2021015254A2 (es) | Anticuerpos anti-pcrv que se unen a pcrv, composiciones que comprenden anticuerpos anti-pcrv, y métodos de uso de estos | |
BR112022015902A2 (pt) | Anticorpos de cd19 anti-humanos | |
ZA202205288B (en) | Humanized antibody and method for using the same | |
MD3365367T2 (ro) | Anticorpi monoclonali împotriva ploşniţelor de pat și procedee de obţinere și utilizare a acestora | |
BR112023024837A2 (pt) | Anticorpos anti-ccr8 |