BR112022018828A2 - Derivados de benzodiazepina como gaba a gamma1 pams - Google Patents

Derivados de benzodiazepina como gaba a gamma1 pams

Info

Publication number
BR112022018828A2
BR112022018828A2 BR112022018828A BR112022018828A BR112022018828A2 BR 112022018828 A2 BR112022018828 A2 BR 112022018828A2 BR 112022018828 A BR112022018828 A BR 112022018828A BR 112022018828 A BR112022018828 A BR 112022018828A BR 112022018828 A2 BR112022018828 A2 BR 112022018828A2
Authority
BR
Brazil
Prior art keywords
gamma1
pams
gaba
benzodiazepine derivatives
compounds
Prior art date
Application number
BR112022018828A
Other languages
English (en)
Inventor
Cecere Giuseppe
Gobbi Luca
Hernandez Maria-Clemencia
Knoflach Frédéric
Koblet Andreas
Cornelius O'connor Eoin
Miguel Olivares Morales Andres
Reutlinger Michael
Runtz-Schmitt Valerie
Ivy Wamsteeker Cusulin Jaclyn
Zorn Nicolas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112022018828A2 publication Critical patent/BR112022018828A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

DERIVADOS DE BENZODIAZEPINA COMO GABA A GAMMA1 PAMS. A presente invenção refere-se a compostos tendo a fórmula geral (I) em que R1, R2, R3, R4, R5 e X são como descritos no presente documento, composições incluindo os compostos e métodos de uso dos compostos.
BR112022018828A 2020-03-31 2021-03-29 Derivados de benzodiazepina como gaba a gamma1 pams BR112022018828A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20167239 2020-03-31
PCT/EP2021/058063 WO2021198124A1 (en) 2020-03-31 2021-03-29 Benzodiazepine derivatives as gaba a gamma1 pams

Publications (1)

Publication Number Publication Date
BR112022018828A2 true BR112022018828A2 (pt) 2022-11-22

Family

ID=70110167

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022018828A BR112022018828A2 (pt) 2020-03-31 2021-03-29 Derivados de benzodiazepina como gaba a gamma1 pams

Country Status (18)

Country Link
US (2) US11739095B2 (pt)
EP (1) EP4126869A1 (pt)
JP (1) JP2023521572A (pt)
KR (1) KR20220161307A (pt)
CN (1) CN115380034A (pt)
AR (1) AR121676A1 (pt)
AU (1) AU2021246833A1 (pt)
BR (1) BR112022018828A2 (pt)
CA (1) CA3167543A1 (pt)
CL (1) CL2022002661A1 (pt)
CO (1) CO2022013856A2 (pt)
CR (1) CR20220478A (pt)
IL (1) IL294350A (pt)
MX (1) MX2022011708A (pt)
PE (1) PE20230440A1 (pt)
TW (1) TW202200585A (pt)
WO (1) WO2021198124A1 (pt)
ZA (1) ZA202207383B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20230440A1 (es) * 2020-03-31 2023-03-08 Hoffmann La Roche Derivados de benzodiazepinas como pam de gaba a gamma1
WO2023213757A1 (en) 2022-05-03 2023-11-09 F. Hoffmann-La Roche Ag Pet tracers for visualizing gabaa gamma1 receptors
WO2024023268A1 (en) 2022-07-29 2024-02-01 F. Hoffmann-La Roche Ag Characterisation of neurological dysfunction

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3987052A (en) * 1969-03-17 1976-10-19 The Upjohn Company 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
US3734922A (en) * 1971-05-11 1973-05-22 Upjohn Co Certain 4h-s-triazolo(4,3-a)(1,4)benzodiazepines
US3681343A (en) * 1971-05-11 1972-08-01 Upjohn Co 6-phenyl-s-triazolo{8 4,3-a{9 {8 1,4{9 {0 benzodiazepines
US4201712A (en) 1975-07-16 1980-05-06 Boehringer Ingelheim Gmbh Process for preparation of 6-aryl-4H-s-triazolo-[3,4-c]-thieno-[2,3-e]-1,4-diazepines
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
PH30676A (en) 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
DE4101146A1 (de) 1991-01-16 1992-07-23 Boehringer Ingelheim Kg Neue in 6-position substituierte diazepine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
MXPA04009332A (es) 2002-03-28 2005-12-12 Wisys Technology Found Inc Agentes ansioliticos con efectos sedantes y ataxicos.
US9006233B2 (en) * 2011-04-28 2015-04-14 Uwm Research Foundation, Inc. Gabaergic receptor subtype selective ligands and their uses
US10266534B2 (en) 2014-06-26 2019-04-23 The Johns Hopkins University Peripherally restricted GABA positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system
AU2017313753B2 (en) * 2016-08-16 2022-01-27 The Trustees Of Columbia University In The City Of New York GABA(A) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma
US20220162173A1 (en) 2019-03-25 2022-05-26 President And Fellows Of Harvard College Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment
PE20230440A1 (es) * 2020-03-31 2023-03-08 Hoffmann La Roche Derivados de benzodiazepinas como pam de gaba a gamma1

Also Published As

Publication number Publication date
AU2021246833A1 (en) 2022-07-21
CO2022013856A2 (es) 2022-10-11
ZA202207383B (en) 2023-04-26
PE20230440A1 (es) 2023-03-08
JP2023521572A (ja) 2023-05-25
EP4126869A1 (en) 2023-02-08
US20210309664A1 (en) 2021-10-07
CL2022002661A1 (es) 2023-03-31
US20240002393A1 (en) 2024-01-04
IL294350A (en) 2022-08-01
WO2021198124A1 (en) 2021-10-07
CR20220478A (es) 2022-10-27
CA3167543A1 (en) 2021-10-07
CN115380034A (zh) 2022-11-22
AR121676A1 (es) 2022-06-29
US11739095B2 (en) 2023-08-29
MX2022011708A (es) 2022-10-07
TW202200585A (zh) 2022-01-01
KR20220161307A (ko) 2022-12-06

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