BR112022013442A2 - Métodos e composições para produção de células de ilhotas xenogênicas e tratamento de condições resistentes ou deficientes à insulina com os mesmos - Google Patents

Métodos e composições para produção de células de ilhotas xenogênicas e tratamento de condições resistentes ou deficientes à insulina com os mesmos

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Publication number
BR112022013442A2
BR112022013442A2 BR112022013442A BR112022013442A BR112022013442A2 BR 112022013442 A2 BR112022013442 A2 BR 112022013442A2 BR 112022013442 A BR112022013442 A BR 112022013442A BR 112022013442 A BR112022013442 A BR 112022013442A BR 112022013442 A2 BR112022013442 A2 BR 112022013442A2
Authority
BR
Brazil
Prior art keywords
compositions
methods
xenogenic
insulin
resistant
Prior art date
Application number
BR112022013442A
Other languages
English (en)
Inventor
Gao Yangbin
Yue Yanan
Yang Luhan
Guell Marc
Kan Yinan
Qin Wenning
Original Assignee
Hangzhou Qihan Biotechnology Co Ltd
Egenesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hangzhou Qihan Biotechnology Co Ltd, Egenesis Inc filed Critical Hangzhou Qihan Biotechnology Co Ltd
Publication of BR112022013442A2 publication Critical patent/BR112022013442A2/pt

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0273—Cloned vertebrates
    • A—HUMAN NECESSITIES
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    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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Abstract

MÉTODOS E COMPOSIÇÕES PARA PRODUÇÃO DE CÉLULAS DE ILHOTAS XENOGÊNICAS E TRATAMENTO DE CONDIÇÕES RESISTENTES OU DEFICIENTES À INSULINA COM OS MESMOS. São descritos aqui métodos, composições e sistemas para gerar células de ilhotas transgênicas apropriadas para xenotransplante.
BR112022013442A 2020-01-07 2021-01-07 Métodos e composições para produção de células de ilhotas xenogênicas e tratamento de condições resistentes ou deficientes à insulina com os mesmos BR112022013442A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2020070698 2020-01-07
PCT/CN2021/070659 WO2021139722A1 (en) 2020-01-07 2021-01-07 Methods and compositions for production of xenogeneic islet cells and treatment of insulin-resistant or -deficient conditions with the same

Publications (1)

Publication Number Publication Date
BR112022013442A2 true BR112022013442A2 (pt) 2022-10-25

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BR112022013442A BR112022013442A2 (pt) 2020-01-07 2021-01-07 Métodos e composições para produção de células de ilhotas xenogênicas e tratamento de condições resistentes ou deficientes à insulina com os mesmos

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Country Link
US (1) US20230056661A1 (pt)
EP (1) EP4087917A4 (pt)
JP (1) JP2023509072A (pt)
KR (1) KR20220147073A (pt)
CN (1) CN115605585A (pt)
AU (1) AU2021205151A1 (pt)
BR (1) BR112022013442A2 (pt)
CA (1) CA3164008A1 (pt)
IL (1) IL294519A (pt)
MX (1) MX2022008362A (pt)
TW (1) TW202140778A (pt)
WO (1) WO2021139722A1 (pt)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011020120A2 (en) * 2009-08-14 2011-02-17 Revivicor, Inc. Multi-transgenic pigs for diabetes treatment
KR102656470B1 (ko) * 2014-12-10 2024-04-09 리전츠 오브 더 유니버스티 오브 미네소타 질환을 치료하기 위한 유전적으로 변형된 세포, 조직 및 장기
US20180249688A1 (en) * 2015-09-09 2018-09-06 Revivicor, Inc Multi-Transgenic Pig for Xenotransplantation
US20190083542A1 (en) * 2017-09-14 2019-03-21 Cell4Vet Corporation Adipose tissue-derived stem cells from transgenic porcine animals for veterinary use
CN108486152B (zh) * 2018-02-13 2021-04-20 深圳市臻质医疗科技有限公司 转基因猪的培育方法和应用
CN110373389A (zh) * 2019-06-10 2019-10-25 云南农业大学 一种适合胰岛细胞及皮肤等组织异种移植供体猪的构建方法

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KR20220147073A (ko) 2022-11-02
US20230056661A1 (en) 2023-02-23
CN115605585A (zh) 2023-01-13
JP2023509072A (ja) 2023-03-06
IL294519A (en) 2022-09-01
CA3164008A1 (en) 2021-07-15
EP4087917A4 (en) 2024-05-29
EP4087917A1 (en) 2022-11-16
MX2022008362A (es) 2022-08-04
WO2021139722A1 (en) 2021-07-15
AU2021205151A1 (en) 2022-07-21
TW202140778A (zh) 2021-11-01

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