BR112022012584A2 - Compostos e derivados de hidroxiestilbeno substituído, síntese e uso deles - Google Patents
Compostos e derivados de hidroxiestilbeno substituído, síntese e uso delesInfo
- Publication number
- BR112022012584A2 BR112022012584A2 BR112022012584A BR112022012584A BR112022012584A2 BR 112022012584 A2 BR112022012584 A2 BR 112022012584A2 BR 112022012584 A BR112022012584 A BR 112022012584A BR 112022012584 A BR112022012584 A BR 112022012584A BR 112022012584 A2 BR112022012584 A2 BR 112022012584A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- derivatives
- substituted
- synthesis
- hydroxystibene
- Prior art date
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- C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
- C07C37/18—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by condensation involving halogen atoms of halogenated compounds
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- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/24—Preparation of ethers by reactions not forming ether-oxygen bonds by elimination of halogens, e.g. elimination of HCl
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
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- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
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- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
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- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
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- C07C225/06—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and acyclic
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- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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Abstract
COMPOSTOS E DERIVADOS DE HIDROXIESTILBENO SUBSTITUÍDO, SÍNTESE E USO DELES. A presente invenção diz respeito a compostos e derivados de hidroxiestilbeno substituído, especificamente compostos e derivados de 2-hidroxiestilbeno substituído, a síntese de referidos compostos e seus usos em terapia
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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AU2019904976 | 2019-12-23 | ||
PCT/AU2020/051431 WO2021127743A1 (en) | 2019-12-23 | 2020-12-23 | Substituted hydroxystilbene compounds and derivatives synthesis and uses thereof |
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BR112022012584A2 true BR112022012584A2 (pt) | 2022-09-27 |
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BR112022012584A BR112022012584A2 (pt) | 2019-12-23 | 2020-12-23 | Compostos e derivados de hidroxiestilbeno substituído, síntese e uso deles |
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US (1) | US20230159421A1 (pt) |
EP (1) | EP4081500A4 (pt) |
JP (1) | JP2023507851A (pt) |
KR (1) | KR20220151159A (pt) |
CN (1) | CN115485259A (pt) |
AU (1) | AU2020415711A1 (pt) |
BR (1) | BR112022012584A2 (pt) |
CA (1) | CA3162498A1 (pt) |
IL (1) | IL294179A (pt) |
MX (1) | MX2022007874A (pt) |
WO (1) | WO2021127743A1 (pt) |
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CN115536530A (zh) * | 2022-10-10 | 2022-12-30 | 浙江大学 | 一种Vulgarisin型四环二萜化合物的化学全合成方法 |
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WO2004078126A2 (en) * | 2003-02-28 | 2004-09-16 | Oxigene, Inc. | Compositions and methods with enhanced therapeutic activity |
WO2009038731A2 (en) * | 2007-09-17 | 2009-03-26 | The Trustees Of Columbia University In The City Of New York | Synthesis of resveratrol-based natural products |
SG194582A1 (en) * | 2011-05-04 | 2013-12-30 | Univ Sydney | Prenylated hydroxystilbenes |
CN105030750B (zh) * | 2011-12-23 | 2018-08-28 | 中国医学科学院医药生物技术研究所 | 一组木豆素结构类似化合物在抗丙肝病毒和抗艾滋病毒的应用 |
CN107011127A (zh) * | 2017-04-21 | 2017-08-04 | 聊城大学 | 一种含氟基团的白藜芦醇衍生物及制备方法和用途 |
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2020
- 2020-12-23 US US17/788,698 patent/US20230159421A1/en active Pending
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EP4081500A1 (en) | 2022-11-02 |
MX2022007874A (es) | 2022-12-02 |
AU2020415711A1 (en) | 2022-08-18 |
JP2023507851A (ja) | 2023-02-27 |
WO2021127743A1 (en) | 2021-07-01 |
KR20220151159A (ko) | 2022-11-14 |
EP4081500A4 (en) | 2024-03-06 |
CN115485259A (zh) | 2022-12-16 |
IL294179A (en) | 2022-08-01 |
CA3162498A1 (en) | 2021-07-01 |
US20230159421A1 (en) | 2023-05-25 |
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