BR112022011788A2 - Separação de oligosacarídeos sialilados de caldo de fermentação - Google Patents
Separação de oligosacarídeos sialilados de caldo de fermentaçãoInfo
- Publication number
- BR112022011788A2 BR112022011788A2 BR112022011788A BR112022011788A BR112022011788A2 BR 112022011788 A2 BR112022011788 A2 BR 112022011788A2 BR 112022011788 A BR112022011788 A BR 112022011788A BR 112022011788 A BR112022011788 A BR 112022011788A BR 112022011788 A2 BR112022011788 A2 BR 112022011788A2
- Authority
- BR
- Brazil
- Prior art keywords
- separation
- fermentation
- break
- sialylated oligosaccharides
- sialylated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/147—Microfiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/16—Feed pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/58—Multistep processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/02—Inorganic material
- B01D71/024—Oxides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/56—Polyamides, e.g. polyester-amides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/20—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbon; comprising carbon obtained by carbonising processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/282—Porous sorbents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/04—Processes using organic exchangers
- B01J39/05—Processes using organic exchangers in the strongly acidic form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/04—Processes using organic exchangers
- B01J41/07—Processes using organic exchangers in the weakly basic form
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/08—Specific process operations in the concentrate stream
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/10—Temperature control
- B01D2311/103—Heating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/18—Details relating to membrane separation process operations and control pH control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2623—Ion-Exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2626—Absorption or adsorption
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2649—Filtration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2676—Centrifugal separation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2697—Chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2317/00—Membrane module arrangements within a plant or an apparatus
- B01D2317/02—Elements in series
- B01D2317/025—Permeate series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
- B01D61/027—Nanofiltration
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Water Supply & Treatment (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
SEPARAÇÃO DE OLIGOSACARÍDEOS SIALILADOS DE CALDO DE FERMENTAÇÃO. A presente invenção refere-se à separação e ao isolamento de oligossacarídeos de leite humano (HMOs) sialilados da mistura reacional na qual são produzidos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201901595 | 2019-12-19 | ||
PCT/IB2020/062166 WO2021124234A1 (en) | 2019-12-19 | 2020-12-18 | Separation of sialylated oligosaccharides from fermentation broth |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022011788A2 true BR112022011788A2 (pt) | 2022-08-30 |
Family
ID=76478234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022011788A BR112022011788A2 (pt) | 2019-12-19 | 2020-12-18 | Separação de oligosacarídeos sialilados de caldo de fermentação |
Country Status (7)
Country | Link |
---|---|
US (1) | US20230030220A1 (pt) |
EP (1) | EP4077702A4 (pt) |
JP (1) | JP2023507247A (pt) |
KR (1) | KR20220116001A (pt) |
CN (1) | CN114829619A (pt) |
BR (1) | BR112022011788A2 (pt) |
WO (1) | WO2021124234A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2024500676A (ja) * | 2020-12-18 | 2024-01-10 | グリコム・アクティーゼルスカブ | 遠心分離によるバイオマス除去 |
WO2022263425A1 (en) * | 2021-06-15 | 2022-12-22 | Dsm Ip Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
BE1029437B1 (nl) * | 2021-06-15 | 2023-07-31 | Dsm Ip Assets Bv | Scheiding van moedermelkoligosachariden uit een fermentatiebouillon |
EP4355464A1 (en) * | 2021-06-15 | 2024-04-24 | DSM IP Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
EP4355463A1 (en) * | 2021-06-15 | 2024-04-24 | DSM IP Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
CN114014896B (zh) * | 2021-10-09 | 2023-12-05 | 中国科学院合肥物质科学研究院 | 一种高纯度3`-唾液酸乳糖的分离纯化方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2796082B1 (fr) * | 1999-07-07 | 2003-06-27 | Centre Nat Rech Scient | Procede de production d'oligosaccharides |
MY148510A (en) * | 2006-03-09 | 2013-04-30 | Centre Nat Rech Scient | Method for producing sialylated oligosaccharides |
JP5599994B2 (ja) * | 2009-09-29 | 2014-10-01 | 雪印メグミルク株式会社 | シアリルラクトース素材の分離方法 |
EP3426670A4 (en) * | 2016-03-07 | 2019-11-13 | Glycom A/S | SEPARATION OF OLIGOSACCHARIDES FROM A FERMENTATION BROTH |
EP3445770A4 (en) * | 2016-04-19 | 2020-03-18 | Glycom A/S | SEPARATION OF OLIGOSACCHARIDES FROM A FERMENTATION BROTH |
MX2019000881A (es) * | 2016-07-28 | 2019-07-01 | Fonterra Cooperative Group Ltd | Producto lacteo y proceso. |
EP3456836A1 (en) * | 2017-09-13 | 2019-03-20 | Glycom A/S | Separation of sialylated oligosaccharides from fermentation broth |
NZ764680A (en) * | 2017-12-08 | 2023-06-30 | Chr Hansen Hmo Gmbh | Spray-dried 3-fucosyllactose |
SG11202106234SA (en) * | 2018-12-19 | 2021-07-29 | Basf Se | Method for separating biomass from a solution comprising biomass and at least one oligosaccaride |
-
2020
- 2020-12-18 BR BR112022011788A patent/BR112022011788A2/pt unknown
- 2020-12-18 WO PCT/IB2020/062166 patent/WO2021124234A1/en unknown
- 2020-12-18 US US17/757,646 patent/US20230030220A1/en active Pending
- 2020-12-18 JP JP2022529307A patent/JP2023507247A/ja active Pending
- 2020-12-18 KR KR1020227024054A patent/KR20220116001A/ko unknown
- 2020-12-18 EP EP20903893.4A patent/EP4077702A4/en active Pending
- 2020-12-18 CN CN202080086952.3A patent/CN114829619A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4077702A1 (en) | 2022-10-26 |
EP4077702A4 (en) | 2023-11-01 |
WO2021124234A1 (en) | 2021-06-24 |
US20230030220A1 (en) | 2023-02-02 |
CN114829619A (zh) | 2022-07-29 |
JP2023507247A (ja) | 2023-02-22 |
KR20220116001A (ko) | 2022-08-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112022011788A2 (pt) | Separação de oligosacarídeos sialilados de caldo de fermentação | |
Lauc et al. | Mechanisms of disease: The human N-glycome | |
Yang et al. | Glycoform analysis of recombinant and human immunodeficiency virus envelope protein gp120 via higher energy collisional dissociation and spectral-aligning strategy | |
BRPI0411715B8 (pt) | composição farmacêutica compreendendo salinosporamidas | |
BR112012022688A2 (pt) | proteína de fusão, vesícula da membrana externa isolada, polinucleotídeo, composição farmacêutica, vacina, método para tratamento ou prevenção de infecção ou doença por neisseria, uso e método para fabricar uma proteína de fusão | |
CL2018000622A1 (es) | Acetamida tienodiazepinas de triazol y sus usos relacionados. | |
BR112013005235A2 (pt) | "métodos e sistemas para processamento de misturas de açúcar e composições resultantes". | |
EP3907283A3 (en) | Buffers for stabilization of lentiviral preparations | |
BR112017005810A2 (pt) | alfa-glucosidase ácida altamente potente com carboidratos melhorados | |
BR112017026545A2 (pt) | sistema portátil que permite que pessoas cegas ou deficientes visuais interpretem o ambiente ao redor através de som ou de toque | |
BR112012015261A2 (pt) | método para gerar, transmitir e receber imagens estereoscópicas, e dispositivos relacionados. | |
MX2021014169A (es) | Purificacion de oligosacaridos a partir de un caldo de fermentacion por medio del uso de filtracion. | |
BR112021026245A2 (pt) | Método de extração. | |
BR112018072118A2 (pt) | anticorpos de interferona beta e usos dos mesmos | |
BR112016023915A2 (pt) | métodos de permissão de reação imunológica, de imunização de mamíferos e de tratamento ou prevenção de infecções, composições, peptídeo isolado, anticorpo, ácido nucleico isolado, construção genética e célula hospedeira | |
BR112018008594A2 (pt) | anticorpos voltados contra um antígeno o de klebsiella pneumoniae baseado em manana, preparação farmacêutica, uso médico e diagnóstico, preparação diagnóstica, ácido nucleico de codificação, cassete de expressão, plasmídeo, célula hospedeira, método de produção e método de identificação de um anticorpo candidato | |
Sharma et al. | Alpha-Gal syndrome: Involvement of Amblyomma americanum α-D-galactosidase and β-1, 4 galactosyltransferase enzymes in α-Gal metabolism | |
GB202014838D0 (en) | Commensal token system | |
BR112015030211A2 (pt) | Vetores lentivirais contendo uma sequência promotora a montante da mhc de classe i, mhc de classe ii ou microglobulina beta-2 | |
Azzouz et al. | Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares | |
WO2020257278A3 (en) | Small molecule target bromo/acetyl proteins and uses thereof | |
MX2017009955A (es) | Anticuerpos orientados a un antigeno o basado en galactano de k. pneumoniae. | |
EA202191942A1 (ru) | Способ разделения продуктов олигомеризации олефинов (варианты) | |
BR112022025005A2 (pt) | Formação de imagem e terapia dirigidas por granzima b | |
WO2023081935A3 (en) | Self-amplifying rna compositions and methods of use thereof |