BR112022011584A2 - Métodos para tratamento da doença de parkinson - Google Patents

Métodos para tratamento da doença de parkinson

Info

Publication number
BR112022011584A2
BR112022011584A2 BR112022011584A BR112022011584A BR112022011584A2 BR 112022011584 A2 BR112022011584 A2 BR 112022011584A2 BR 112022011584 A BR112022011584 A BR 112022011584A BR 112022011584 A BR112022011584 A BR 112022011584A BR 112022011584 A2 BR112022011584 A2 BR 112022011584A2
Authority
BR
Brazil
Prior art keywords
subject
parkinson
disease
methods
treatment
Prior art date
Application number
BR112022011584A
Other languages
English (en)
Portuguese (pt)
Inventor
Forbes Alexandria
During Matthew
Original Assignee
Meiragtx Uk Ii Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiragtx Uk Ii Ltd filed Critical Meiragtx Uk Ii Ltd
Publication of BR112022011584A2 publication Critical patent/BR112022011584A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01015—Glutamate decarboxylase (4.1.1.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR112022011584A 2019-12-12 2020-12-14 Métodos para tratamento da doença de parkinson BR112022011584A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962947418P 2019-12-12 2019-12-12
PCT/US2020/064928 WO2021119615A1 (en) 2019-12-12 2020-12-14 Methods for treating parkinson's disease

Publications (1)

Publication Number Publication Date
BR112022011584A2 true BR112022011584A2 (pt) 2022-12-13

Family

ID=76330812

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022011584A BR112022011584A2 (pt) 2019-12-12 2020-12-14 Métodos para tratamento da doença de parkinson

Country Status (10)

Country Link
US (1) US20230050187A1 (enExample)
EP (1) EP4072568A4 (enExample)
JP (2) JP7758671B2 (enExample)
KR (1) KR20220114028A (enExample)
AU (1) AU2020403266A1 (enExample)
BR (1) BR112022011584A2 (enExample)
CA (1) CA3161322A1 (enExample)
IL (1) IL293776A (enExample)
MX (1) MX2022007193A (enExample)
WO (1) WO2021119615A1 (enExample)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2409674C (en) * 2000-05-23 2010-05-11 Neurologix, Inc. Glutamic acid decarboxylase (gad) based delivery systems
US7695959B2 (en) * 2000-05-23 2010-04-13 Neurologix, Inc. Glutamic acid decarboxylase (GAD) based delivery systems
US20030087264A1 (en) * 2001-05-22 2003-05-08 Kaplitt Michael G. Transcriptional regulation of target genes
CA2610164A1 (en) * 2005-05-31 2006-12-07 Neurologix, Inc. Novel glutamic acid decarboxylase (gad) chimera and methods of use
JOP20190269A1 (ar) * 2017-06-15 2019-11-20 Voyager Therapeutics Inc بولي نوكليوتيدات aadc لعلاج مرض باركنسون

Also Published As

Publication number Publication date
EP4072568A1 (en) 2022-10-19
CA3161322A1 (en) 2021-06-17
IL293776A (en) 2022-08-01
AU2020403266A1 (en) 2022-08-04
KR20220114028A (ko) 2022-08-17
JP2025188191A (ja) 2025-12-25
JP2023506007A (ja) 2023-02-14
MX2022007193A (es) 2022-09-19
JP7758671B2 (ja) 2025-10-22
WO2021119615A1 (en) 2021-06-17
EP4072568A4 (en) 2024-02-07
US20230050187A1 (en) 2023-02-16

Similar Documents

Publication Publication Date Title
Marino et al. Parkinson’s disease: a review from pathophysiology to treatment
Park et al. Human adipose tissue‐derived mesenchymal stem cells improve cognitive function and physical activity in ageing mice
Fitzgerald et al. An open label trial of clustered maintenance rTMS for patients with refractory depression
Knott et al. Cyclic AMP signaling: a molecular determinant of peripheral nerve regeneration
Tan et al. Angelman syndrome: current and emerging therapies in 2016
Klinkenberg et al. Vagus nerve stimulation in children with intractable epilepsy: a randomized controlled trial
Thompson et al. Spatiotemporal patterns of gene expression around implanted silicon electrode arrays
Imagama et al. Keratan sulfate restricts neural plasticity after spinal cord injury
Crombie et al. Aerobic exercise and consolidation of fear extinction learning among women with posttraumatic stress disorder
BR112021017720A2 (pt) Sistemas e métodos para tratamento de distúrbios respiratórios do sono
BR112012008033A2 (pt) sistema para estimulação do nervo trigêmeo para tratamento de um distúrbio ou condição neurológicos, unidade de eletrodo subcutâneo, método para tratar um distúrbio ou condição neurológicos, e, kit para estimulação do nervo trigêmeo
BR112021021921A2 (pt) Agente, uso de um agente e método de tratamento ou prevenção de uma doença metabólica
BR112015017775A2 (pt) enzima cistationina beta-sintase para o tratamento de homocistinúria
ATE280590T1 (de) Glutaminsäure decarboxylase (gad) abgabesystem zur behandlung neurodegeneraliver erkrankungen
WO2005004794A3 (en) Method of treating neurodegenerative disease
CY1125450T1 (el) Ευγευστες συνθεσεις οι οποιες περιλαμβανουν φαινυλοβουτυρικο νατριο και χρησεις αυτων
BR112015022156A2 (pt) composições e métodos para modular a expressão de tau
MX2010003548A (es) Metodos para el tratamiento de padecimientos neurologicos autoinmunes con ciclofosfamida.
BR112018014288A2 (pt) métodos e composições para o tratamento de doença neurológica
BR112018008344A2 (pt) molécula de ácido nucleico, composição farmacêutica, vetor ou célula, método para prevenir, tratar ou melhorar uma doença, e, uso de uma composição
MX2024000237A (es) Arnip que inhibe la expresión del gen angptl3 y uso del mismo.
JP2020533281A (ja) デキストラン硫酸の新規使用
WO2005037211A3 (en) Methods and compositions for the treatment of neurological disease
EP4230197A3 (en) High concentration medicant solutions for treating neurological disorders
PH12020551191A1 (en) Oligodendrocyte-specific promoter, mirna specific to plp1 gene, vector including said promoter and/or mirna, and pharmaceutical composition including said vector

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: MEIRAGTX NEURO I, LLC (US)