BR112022010186A2 - Moduladores de canal iônico - Google Patents
Moduladores de canal iônicoInfo
- Publication number
- BR112022010186A2 BR112022010186A2 BR112022010186A BR112022010186A BR112022010186A2 BR 112022010186 A2 BR112022010186 A2 BR 112022010186A2 BR 112022010186 A BR112022010186 A BR 112022010186A BR 112022010186 A BR112022010186 A BR 112022010186A BR 112022010186 A2 BR112022010186 A2 BR 112022010186A2
- Authority
- BR
- Brazil
- Prior art keywords
- ion channel
- channel modulators
- disease
- treating
- aberrant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Transmitters (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
- Amplifiers (AREA)
Abstract
MODULADORES DE CANAL IÔNICO. A presente invenção refere-se, em parte, a compostos e composições de heteroarila fundida úteis para prevenir e/ou tratar uma doença ou condição relacionada à função aberrante de um canal de íons de sódio dependente de voltagem, por exemplo, de corrente de sódio tardia/persistente anormal. A presente invenção também se refere a métodos de tratamento de uma doença ou condição relacionada à função aberrante de um canal iônico de sódio, incluindo transtornos neurológicos (por exemplo, síndrome de Dravet, epilepsia), dor e distúrbios neuromusculares.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962940500P | 2019-11-26 | 2019-11-26 | |
| PCT/US2020/062179 WO2021108513A1 (en) | 2019-11-26 | 2020-11-25 | Ion channel modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022010186A2 true BR112022010186A2 (pt) | 2022-08-09 |
Family
ID=76129716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022010186A BR112022010186A2 (pt) | 2019-11-26 | 2020-11-25 | Moduladores de canal iônico |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20230034917A1 (pt) |
| EP (1) | EP4065124A4 (pt) |
| JP (1) | JP2023503343A (pt) |
| KR (1) | KR20220119624A (pt) |
| CN (1) | CN114980899A (pt) |
| AU (1) | AU2020394421A1 (pt) |
| BR (1) | BR112022010186A2 (pt) |
| CA (1) | CA3162893A1 (pt) |
| CL (1) | CL2022001373A1 (pt) |
| CO (1) | CO2022008766A2 (pt) |
| EC (1) | ECSP22049654A (pt) |
| IL (1) | IL293256A (pt) |
| MX (1) | MX2022006317A (pt) |
| PE (1) | PE20221087A1 (pt) |
| SA (1) | SA522432719B1 (pt) |
| WO (1) | WO2021108513A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018098491A1 (en) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| CN116763791A (zh) | 2016-11-28 | 2023-09-19 | 普拉克西斯精密药物股份有限公司 | 化合物以及它们的使用方法 |
| WO2018148745A1 (en) | 2017-02-13 | 2018-08-16 | Praxis Precision Medicines , Inc. | Compounds and their methods of use |
| WO2018187480A1 (en) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11278535B2 (en) | 2017-08-15 | 2022-03-22 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| CN117756800A (zh) | 2018-05-30 | 2024-03-26 | 普拉克西斯精密药物股份有限公司 | 离子通道调节剂 |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| US20240148709A1 (en) * | 2022-11-08 | 2024-05-09 | Aisa Pharma, Inc. | Methods of treating eye pain and eye disorders |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010276537B2 (en) * | 2009-07-27 | 2015-04-16 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
| KR20230124760A (ko) * | 2016-09-02 | 2023-08-25 | 사이클리온 테라퓨틱스, 인크. | 융합된 비시클릭 sGC 자극제 |
| WO2018098491A1 (en) * | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| CN116763791A (zh) * | 2016-11-28 | 2023-09-19 | 普拉克西斯精密药物股份有限公司 | 化合物以及它们的使用方法 |
| WO2018187480A1 (en) * | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| CN117756800A (zh) * | 2018-05-30 | 2024-03-26 | 普拉克西斯精密药物股份有限公司 | 离子通道调节剂 |
| US11279700B2 (en) * | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| US11505554B2 (en) * | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| WO2021108625A1 (en) * | 2019-11-27 | 2021-06-03 | Praxis Precision Medicines, Inc. | Formulations of ion channel modulators and methods of preparation and use of ion channel modulators |
| WO2023211852A1 (en) * | 2022-04-26 | 2023-11-02 | Praxis Precision Medicines, Inc. | Treatment of neurological disorders |
-
2020
- 2020-11-25 BR BR112022010186A patent/BR112022010186A2/pt unknown
- 2020-11-25 US US17/780,042 patent/US20230034917A1/en active Pending
- 2020-11-25 PE PE2022000858A patent/PE20221087A1/es unknown
- 2020-11-25 IL IL293256A patent/IL293256A/en unknown
- 2020-11-25 MX MX2022006317A patent/MX2022006317A/es unknown
- 2020-11-25 KR KR1020227021533A patent/KR20220119624A/ko unknown
- 2020-11-25 WO PCT/US2020/062179 patent/WO2021108513A1/en active Application Filing
- 2020-11-25 EP EP20893553.6A patent/EP4065124A4/en active Pending
- 2020-11-25 CA CA3162893A patent/CA3162893A1/en active Pending
- 2020-11-25 CN CN202080093800.6A patent/CN114980899A/zh active Pending
- 2020-11-25 JP JP2022530673A patent/JP2023503343A/ja active Pending
- 2020-11-25 AU AU2020394421A patent/AU2020394421A1/en active Pending
-
2022
- 2022-05-25 SA SA522432719A patent/SA522432719B1/ar unknown
- 2022-05-25 CL CL2022001373A patent/CL2022001373A1/es unknown
- 2022-06-23 CO CONC2022/0008766A patent/CO2022008766A2/es unknown
- 2022-06-23 EC ECSENADI202249654A patent/ECSP22049654A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN114980899A (zh) | 2022-08-30 |
| WO2021108513A1 (en) | 2021-06-03 |
| AU2020394421A1 (en) | 2022-06-09 |
| CO2022008766A2 (es) | 2022-07-19 |
| MX2022006317A (es) | 2022-06-22 |
| SA522432719B1 (ar) | 2023-12-13 |
| CL2022001373A1 (es) | 2023-03-10 |
| KR20220119624A (ko) | 2022-08-30 |
| US20230034917A1 (en) | 2023-02-02 |
| JP2023503343A (ja) | 2023-01-27 |
| EP4065124A1 (en) | 2022-10-05 |
| CA3162893A1 (en) | 2021-06-03 |
| EP4065124A4 (en) | 2023-12-06 |
| IL293256A (en) | 2022-07-01 |
| PE20221087A1 (es) | 2022-07-05 |
| ECSP22049654A (es) | 2022-07-29 |
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