CO2022008766A2 - Moduladores de canales iónicos - Google Patents

Moduladores de canales iónicos

Info

Publication number
CO2022008766A2
CO2022008766A2 CONC2022/0008766A CO2022008766A CO2022008766A2 CO 2022008766 A2 CO2022008766 A2 CO 2022008766A2 CO 2022008766 A CO2022008766 A CO 2022008766A CO 2022008766 A2 CO2022008766 A2 CO 2022008766A2
Authority
CO
Colombia
Prior art keywords
ion channel
abnormal
disease
treating
channel modulators
Prior art date
Application number
CONC2022/0008766A
Other languages
English (en)
Inventor
Botella Gabriel Martinez
Kiran Reddy
Andrew Mark Griffin
Brian Edward Marron
Carlos Loya
Original Assignee
Praxis Prec Medicines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Praxis Prec Medicines Inc filed Critical Praxis Prec Medicines Inc
Publication of CO2022008766A2 publication Critical patent/CO2022008766A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transmitters (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
  • Amplifiers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere, en parte, a compuestos y composiciones de heteroarilo fusionado útiles para prevenir y/o tratar una enfermedad o afección relacionada con la función anómala de un canal de ion sodio sensible al voltaje, por ejemplo, corriente de sodio anormal tardía/constante. Los métodos para tratar una enfermedad o afección relacionada con la función anómala de un canal de ion sodio que incluye trastornos neurológicos (p. ej., síndrome de Dravet, epilepsia), dolor, y trastornos neuromusculares también se proporcionan en la presente descripción.
CONC2022/0008766A 2019-11-26 2022-06-23 Moduladores de canales iónicos CO2022008766A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962940500P 2019-11-26 2019-11-26
PCT/US2020/062179 WO2021108513A1 (en) 2019-11-26 2020-11-25 Ion channel modulators

Publications (1)

Publication Number Publication Date
CO2022008766A2 true CO2022008766A2 (es) 2022-07-19

Family

ID=76129716

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2022/0008766A CO2022008766A2 (es) 2019-11-26 2022-06-23 Moduladores de canales iónicos

Country Status (15)

Country Link
US (1) US20230034917A1 (es)
EP (1) EP4065124A4 (es)
JP (1) JP2023503343A (es)
KR (1) KR20220119624A (es)
CN (1) CN114980899A (es)
AU (1) AU2020394421A1 (es)
BR (1) BR112022010186A2 (es)
CA (1) CA3162893A1 (es)
CL (1) CL2022001373A1 (es)
CO (1) CO2022008766A2 (es)
EC (1) ECSP22049654A (es)
IL (1) IL293256A (es)
MX (1) MX2022006317A (es)
PE (1) PE20221087A1 (es)
WO (1) WO2021108513A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11261188B2 (en) 2016-11-28 2022-03-01 Praxis Precision Medicines, Inc. Fused heteroaryl compounds, and methods thereof for treating diseases, disorders, and conditions relating to aberrant function of a sodium channel
AU2017364901A1 (en) 2016-11-28 2019-06-13 Praxis Precision Medicines, Inc. Compounds and their methods of use
WO2018148745A1 (en) 2017-02-13 2018-08-16 Praxis Precision Medicines , Inc. Compounds and their methods of use
US11731966B2 (en) 2017-04-04 2023-08-22 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11278535B2 (en) 2017-08-15 2022-03-22 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11866439B2 (en) 2018-05-30 2024-01-09 Praxis Precision Medicines, Inc. Ion channel modulators
US11773099B2 (en) 2019-05-28 2023-10-03 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11279700B2 (en) 2019-05-31 2022-03-22 Praxis Precision Medicines, Inc. Ion channel modulators
US11505554B2 (en) 2019-05-31 2022-11-22 Praxis Precision Medicines, Inc. Substituted pyridines as ion channel modulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME02847B (me) * 2009-07-27 2018-01-20 Gilead Sciences Inc Fuzionisana heterociklična jedinjenja kao modulatori jonskih kanala
CR20190101A (es) * 2016-09-02 2019-07-04 Ironwood Pharmaceuticals Inc Estimuladores de sgc
US11261188B2 (en) * 2016-11-28 2022-03-01 Praxis Precision Medicines, Inc. Fused heteroaryl compounds, and methods thereof for treating diseases, disorders, and conditions relating to aberrant function of a sodium channel
AU2017364901A1 (en) * 2016-11-28 2019-06-13 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11731966B2 (en) * 2017-04-04 2023-08-22 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11866439B2 (en) * 2018-05-30 2024-01-09 Praxis Precision Medicines, Inc. Ion channel modulators
US11279700B2 (en) * 2019-05-31 2022-03-22 Praxis Precision Medicines, Inc. Ion channel modulators
US11505554B2 (en) * 2019-05-31 2022-11-22 Praxis Precision Medicines, Inc. Substituted pyridines as ion channel modulators
WO2021108625A1 (en) * 2019-11-27 2021-06-03 Praxis Precision Medicines, Inc. Formulations of ion channel modulators and methods of preparation and use of ion channel modulators
WO2023211852A1 (en) * 2022-04-26 2023-11-02 Praxis Precision Medicines, Inc. Treatment of neurological disorders

Also Published As

Publication number Publication date
PE20221087A1 (es) 2022-07-05
CN114980899A (zh) 2022-08-30
MX2022006317A (es) 2022-06-22
KR20220119624A (ko) 2022-08-30
EP4065124A4 (en) 2023-12-06
US20230034917A1 (en) 2023-02-02
ECSP22049654A (es) 2022-07-29
IL293256A (en) 2022-07-01
BR112022010186A2 (pt) 2022-08-09
AU2020394421A1 (en) 2022-06-09
JP2023503343A (ja) 2023-01-27
WO2021108513A1 (en) 2021-06-03
EP4065124A1 (en) 2022-10-05
CL2022001373A1 (es) 2023-03-10
CA3162893A1 (en) 2021-06-03

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