BR112022009429A2 - Vacina de partícula lipídica de ácido nucleico encapsulando o mrna de hpv - Google Patents

Vacina de partícula lipídica de ácido nucleico encapsulando o mrna de hpv

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Publication number
BR112022009429A2
BR112022009429A2 BR112022009429A BR112022009429A BR112022009429A2 BR 112022009429 A2 BR112022009429 A2 BR 112022009429A2 BR 112022009429 A BR112022009429 A BR 112022009429A BR 112022009429 A BR112022009429 A BR 112022009429A BR 112022009429 A2 BR112022009429 A2 BR 112022009429A2
Authority
BR
Brazil
Prior art keywords
nucleic acid
encapsulating
lipid particle
acid lipid
hpv mrna
Prior art date
Application number
BR112022009429A
Other languages
English (en)
Portuguese (pt)
Inventor
Niwa Takako
Suzuki Takashi
Koizumi Makoto
Jonai Nao
ONODERA Yoshikuni
Takeshita Fumihiko
Ishii Ken
Original Assignee
Daiichi Sankyo Co Ltd
Nat Inst Biomedical Innovation Health & Nutrition
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd, Nat Inst Biomedical Innovation Health & Nutrition filed Critical Daiichi Sankyo Co Ltd
Publication of BR112022009429A2 publication Critical patent/BR112022009429A2/pt

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    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
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    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
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    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K47/6921Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
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    • A61K48/0025Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0033Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
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    • C07KPEPTIDES
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    • C12N15/09Recombinant DNA-technology
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    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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BR112022009429A 2019-11-15 2020-11-13 Vacina de partícula lipídica de ácido nucleico encapsulando o mrna de hpv BR112022009429A2 (pt)

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JP2019207001 2019-11-15
PCT/JP2020/042405 WO2021095838A1 (ja) 2019-11-15 2020-11-13 HPV mRNAを封入した核酸脂質粒子ワクチン

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BR112022009429A2 true BR112022009429A2 (pt) 2022-08-09

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Country Link
US (1) US20220409540A1 (enrdf_load_stackoverflow)
EP (1) EP4059515A4 (enrdf_load_stackoverflow)
JP (2) JPWO2021095838A1 (enrdf_load_stackoverflow)
KR (1) KR20220102617A (enrdf_load_stackoverflow)
CN (1) CN114650841A (enrdf_load_stackoverflow)
AU (1) AU2020382378A1 (enrdf_load_stackoverflow)
BR (1) BR112022009429A2 (enrdf_load_stackoverflow)
CA (1) CA3160839A1 (enrdf_load_stackoverflow)
IL (1) IL292989A (enrdf_load_stackoverflow)
TW (1) TW202131945A (enrdf_load_stackoverflow)
WO (1) WO2021095838A1 (enrdf_load_stackoverflow)

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JPWO2022244815A1 (enrdf_load_stackoverflow) * 2021-05-19 2022-11-24
EP4364752A1 (en) * 2022-11-07 2024-05-08 OncoDNA Improved vaccine
WO2024131833A1 (en) * 2022-12-21 2024-06-27 Abogen Biosciences (Shanghai) Co., Ltd. Mrna-based hpv+ cancer vaccines, and uses thereof
CN117398456A (zh) * 2023-10-17 2024-01-16 中国药科大学 一种特异性标记异源蛋白的肿瘤新抗原疫苗体系及其应用

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JP6567824B2 (ja) * 2011-10-12 2019-08-28 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア ヒトパピローマウイルスのワクチンおよびその使用方法
JP6517779B2 (ja) 2013-03-12 2019-05-22 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア ヒトパピローマウイルスの改良型ワクチンおよびその使用方法
TW201534578A (zh) 2013-07-08 2015-09-16 Daiichi Sankyo Co Ltd 新穎脂質
US10125092B2 (en) * 2014-09-05 2018-11-13 Novartis Ag Lipids and lipid compositions for the delivery of active agents
SG11201903674YA (en) * 2016-10-26 2019-05-30 Modernatx Inc Messenger ribonucleic acids for enhancing immune responses and methods of use thereof
MX2019009070A (es) * 2017-02-01 2019-10-30 Modernatx Inc Composiciones de arnm terapeuticas inmunomoduladoras que codifican peptidos de mutacion de oncogenes de activacion.
JP7060448B2 (ja) 2018-05-29 2022-04-26 株式会社ミツバ ギア、および減速機付きモータ
JPWO2022244815A1 (enrdf_load_stackoverflow) * 2021-05-19 2022-11-24

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