BR112022007837A2 - Combinação de um inibidor de ahr e um anticorpo inibidor de pd1 e seu uso no tratamento de câncer - Google Patents
Combinação de um inibidor de ahr e um anticorpo inibidor de pd1 e seu uso no tratamento de câncerInfo
- Publication number
- BR112022007837A2 BR112022007837A2 BR112022007837A BR112022007837A BR112022007837A2 BR 112022007837 A2 BR112022007837 A2 BR 112022007837A2 BR 112022007837 A BR112022007837 A BR 112022007837A BR 112022007837 A BR112022007837 A BR 112022007837A BR 112022007837 A2 BR112022007837 A2 BR 112022007837A2
- Authority
- BR
- Brazil
- Prior art keywords
- component
- inhibitor
- treatment
- ahr
- cancer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
COMBINAÇÃO DE UM INIBIDOR DE AhR E UM ANTICORPO INIBIDOR DE PD1 E SEU USO NO TRATAMENTO DE CÂNCER. A presente invenção refere-se a combinações de pelo menos dois componentes, componente A e componente B, o componente A sendo um inibidor de AhR e o componente B sendo pembrolizumab ou nivolumab. Um outro aspecto da presente invenção refere-se a combinações de três componentes, componente A, componente B e componente C; o componente A sendo um inibidor de AhR, o componente B sendo pembrolizumab ou nivolumab e o componente C sendo um agente farmacêutico adicional. A presente invenção refere-se ainda ao uso de tais combinações como descrito no presente documento para a preparação de um medicamento para o tratamento ou profilaxia de uma doença, particularmente para o tratamento ou profilaxia de cânceres de mama, trato respiratório, cérebro, órgãos reprodutivos, trato digestivo, trato urinário, olho, fígado, pele, rim, cabeça e pescoço, tireoide, paratireoide e metástases distantes dos mesmos, linfomas, sarcomas e leucemias.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962948430P | 2019-12-16 | 2019-12-16 | |
EP19216672 | 2019-12-16 | ||
PCT/EP2020/085938 WO2021122434A1 (en) | 2019-12-16 | 2020-12-14 | Combination of an ahr-inhibitor and an pd1-inhibitor antibody and its use in the treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022007837A2 true BR112022007837A2 (pt) | 2022-07-05 |
Family
ID=73790120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022007837A BR112022007837A2 (pt) | 2019-12-16 | 2020-12-14 | Combinação de um inibidor de ahr e um anticorpo inibidor de pd1 e seu uso no tratamento de câncer |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230084899A1 (pt) |
EP (1) | EP4076462A1 (pt) |
JP (1) | JP2023505907A (pt) |
KR (1) | KR20220128622A (pt) |
CN (1) | CN114786674A (pt) |
AU (1) | AU2020403801A1 (pt) |
BR (1) | BR112022007837A2 (pt) |
CA (1) | CA3164474A1 (pt) |
IL (1) | IL293861A (pt) |
MX (1) | MX2022007438A (pt) |
WO (1) | WO2021122434A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114835687B (zh) * | 2021-04-02 | 2023-09-05 | 北京华森英诺生物科技有限公司 | AhR抑制剂 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
CA2970873C (en) | 2005-05-09 | 2022-05-17 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
EP3222634A1 (en) | 2007-06-18 | 2017-09-27 | Merck Sharp & Dohme B.V. | Antibodies to human programmed death receptor pd-1 |
CN105461687B (zh) * | 2014-08-26 | 2020-06-19 | 北京京奉医药科技有限公司 | 含二氢哒嗪酮的喹啉类化合物及其用途 |
MX2018014443A (es) * | 2016-05-25 | 2019-04-15 | Bayer Pharma AG | 3-oxo-2,6-difenil-2,3-dihidropiridazin-4-carboxamidas. |
JOP20190193A1 (ar) | 2017-02-09 | 2019-08-08 | Bayer Pharma AG | ممركبات 2-أريل غير متجانس-3-أكسو-2، 3-ثنائي هيدرو بيريدازين-4-كربوكساميد لمعالجة السرطان |
WO2019101643A1 (en) * | 2017-11-21 | 2019-05-31 | Bayer Aktiengesellschaft | 3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyridazine-4-carboxamides |
US11459312B2 (en) * | 2017-11-21 | 2022-10-04 | Bayer Aktiengesellschaft | Sulphur substituted 3-oxo-2,3-dihydropyridazine-4-carboxamides |
-
2020
- 2020-12-14 KR KR1020227024133A patent/KR20220128622A/ko unknown
- 2020-12-14 EP EP20821233.2A patent/EP4076462A1/en active Pending
- 2020-12-14 CN CN202080084993.9A patent/CN114786674A/zh active Pending
- 2020-12-14 BR BR112022007837A patent/BR112022007837A2/pt unknown
- 2020-12-14 CA CA3164474A patent/CA3164474A1/en active Pending
- 2020-12-14 WO PCT/EP2020/085938 patent/WO2021122434A1/en unknown
- 2020-12-14 MX MX2022007438A patent/MX2022007438A/es unknown
- 2020-12-14 JP JP2022536613A patent/JP2023505907A/ja active Pending
- 2020-12-14 AU AU2020403801A patent/AU2020403801A1/en active Pending
- 2020-12-14 IL IL293861A patent/IL293861A/en unknown
- 2020-12-14 US US17/785,860 patent/US20230084899A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
IL293861A (en) | 2022-08-01 |
JP2023505907A (ja) | 2023-02-13 |
EP4076462A1 (en) | 2022-10-26 |
CA3164474A1 (en) | 2021-06-24 |
MX2022007438A (es) | 2022-07-19 |
US20230084899A1 (en) | 2023-03-16 |
CN114786674A (zh) | 2022-07-22 |
KR20220128622A (ko) | 2022-09-21 |
WO2021122434A1 (en) | 2021-06-24 |
AU2020403801A1 (en) | 2022-06-02 |
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