BR112022005182A2 - Composto de amida heterocíclico, sal farmaceuticamente aceitável do mesmo, e método de preparação do mesmo e uso do mesmo - Google Patents
Composto de amida heterocíclico, sal farmaceuticamente aceitável do mesmo, e método de preparação do mesmo e uso do mesmoInfo
- Publication number
- BR112022005182A2 BR112022005182A2 BR112022005182A BR112022005182A BR112022005182A2 BR 112022005182 A2 BR112022005182 A2 BR 112022005182A2 BR 112022005182 A BR112022005182 A BR 112022005182A BR 112022005182 A BR112022005182 A BR 112022005182A BR 112022005182 A2 BR112022005182 A2 BR 112022005182A2
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- pharmaceutically acceptable
- acceptable salt
- amide compound
- heterocyclic amide
- Prior art date
Links
- -1 Heterocyclic amide compound Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 101150037787 Sting gene Proteins 0.000 abstract 2
- 101150060741 Sting1 gene Proteins 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000568 immunological adjuvant Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
composto de amida heterocíclico, sal farmaceuticamente aceitável do mesmo, e método de preparação do mesmo e uso do mesmo. são fornecidos um composto de amida heterocíclico de fórmula geral (i), um sal farmaceuticamente aceitável do mesmo e um método de preparação do mesmo, e o uso do composto na preparação de um fármaco para tratar doenças relacionadas à atividade de sting, na preparação de um adjuvante imunológico, e na preparação de um fármaco para ativar sting.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910891002.7A CN112521394A (zh) | 2019-09-19 | 2019-09-19 | 杂环酰胺类化合物、其可药用的盐及其制备方法和用途 |
PCT/CN2020/116614 WO2021052501A1 (zh) | 2019-09-19 | 2020-09-21 | 杂环酰胺类化合物、其可药用的盐及其制备方法和用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022005182A2 true BR112022005182A2 (pt) | 2022-06-14 |
Family
ID=74883932
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022005182A BR112022005182A2 (pt) | 2019-09-19 | 2020-09-21 | Composto de amida heterocíclico, sal farmaceuticamente aceitável do mesmo, e método de preparação do mesmo e uso do mesmo |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220389025A1 (pt) |
EP (1) | EP4032890A1 (pt) |
JP (1) | JP2022549030A (pt) |
KR (1) | KR20220097388A (pt) |
CN (2) | CN112521394A (pt) |
AU (1) | AU2020348825B2 (pt) |
BR (1) | BR112022005182A2 (pt) |
CA (1) | CA3151776C (pt) |
MX (1) | MX2022003270A (pt) |
WO (1) | WO2021052501A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112521394A (zh) * | 2019-09-19 | 2021-03-19 | 中国药科大学 | 杂环酰胺类化合物、其可药用的盐及其制备方法和用途 |
US20220388986A1 (en) * | 2021-04-29 | 2022-12-08 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds capable of activating sting |
CN116332885A (zh) * | 2023-02-13 | 2023-06-27 | 中国海洋大学 | 一种硝基杂环类sting激动剂及其制备方法和用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL295649A (en) * | 2016-04-07 | 2022-10-01 | Glaxosmithkline Ip Dev Ltd | Heterocyclic amides are useful as protein modulators |
EP3691640A1 (en) * | 2017-10-05 | 2020-08-12 | GlaxoSmithKline Intellectual Property Development Limited | Methods for administering sting agonists |
CN110016025B (zh) * | 2018-01-08 | 2021-08-06 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
WO2020028566A1 (en) * | 2018-07-31 | 2020-02-06 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
CN112521394A (zh) * | 2019-09-19 | 2021-03-19 | 中国药科大学 | 杂环酰胺类化合物、其可药用的盐及其制备方法和用途 |
-
2019
- 2019-09-19 CN CN201910891002.7A patent/CN112521394A/zh active Pending
-
2020
- 2020-09-21 EP EP20866743.6A patent/EP4032890A1/en not_active Withdrawn
- 2020-09-21 MX MX2022003270A patent/MX2022003270A/es unknown
- 2020-09-21 JP JP2022543603A patent/JP2022549030A/ja not_active Withdrawn
- 2020-09-21 AU AU2020348825A patent/AU2020348825B2/en active Active
- 2020-09-21 US US17/761,252 patent/US20220389025A1/en active Pending
- 2020-09-21 CA CA3151776A patent/CA3151776C/en active Active
- 2020-09-21 BR BR112022005182A patent/BR112022005182A2/pt not_active Application Discontinuation
- 2020-09-21 CN CN202080066382.1A patent/CN114981273B/zh active Active
- 2020-09-21 KR KR1020227012596A patent/KR20220097388A/ko unknown
- 2020-09-21 WO PCT/CN2020/116614 patent/WO2021052501A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU2020348825B2 (en) | 2023-12-21 |
US20220389025A1 (en) | 2022-12-08 |
AU2020348825A1 (en) | 2022-04-28 |
MX2022003270A (es) | 2022-07-04 |
CA3151776C (en) | 2024-04-09 |
EP4032890A1 (en) | 2022-07-27 |
CA3151776A1 (en) | 2021-03-25 |
KR20220097388A (ko) | 2022-07-07 |
CN114981273B (zh) | 2024-03-01 |
JP2022549030A (ja) | 2022-11-22 |
WO2021052501A1 (zh) | 2021-03-25 |
CN114981273A (zh) | 2022-08-30 |
CN112521394A (zh) | 2021-03-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112022005182A2 (pt) | Composto de amida heterocíclico, sal farmaceuticamente aceitável do mesmo, e método de preparação do mesmo e uso do mesmo | |
CO2019008531A2 (es) | Análogos de atazanavir (atv) para tratar infecciones por vih. | |
CL2022001625A1 (es) | Derivados de pirazolilo útiles como agentes anti-cancerígenos | |
CL2020002866A1 (es) | Compuestos de heteroaril tetracíclicos | |
BR112019007393A2 (pt) | derivados 6,7,8,9-tetra-hidro-3h-pirazolo[4,3-f]isoquinolina úteis no tratamento de câncer | |
CO2017008862A2 (es) | Composiciones farmacéuticas que comprenden n-(3,5-dimetoxifenil)-n’-(1-metiletil)-n-[3-(1-metil-1h-pirazol-4-il-quinoxalin-6-il]etano-1,2-diamina | |
BR112018070602A2 (pt) | composto, composição farmacêutica, uso do composto, e, método para tratar uma doença ou distúrbio | |
CR20150628A (es) | Derivados de la pirazolopirrolidina y su uso en el tratamiento de enfermedades | |
BR112022010254A2 (pt) | Composto heterocíclico contendo oxigênio representado pela fórmula i, método para preparar o composto heterocíclico contendo oxigênio, composto, composição farmacêutica e uso composto heterocíclico contendo oxigênio | |
AR095034A1 (es) | El uso de los agonistas del receptor 2 del péptido formilo para el tratamiento de las enfermedades inflamatorias oculares | |
EA201792116A1 (ru) | Ингибитор янус-киназы | |
BR112014003237A2 (pt) | compostos de indazol, composições e métodos de uso | |
CO2021002977A2 (es) | Dimetilaminoazetidinaminas como inhibidores de jak | |
EA201070167A1 (ru) | Замещенные производные индазола, активные как ингибиторы киназы | |
MX2021012750A (es) | Agonista de molécula pequeña del fxr y método de preparación para el mismo y uso del mismo. | |
CR20210213A (es) | Derivados de quinolina como inhibidores de la integrina alfa4beta7 | |
CO2021002976A2 (es) | Amidas heterocíclicas de 5 a 7 miembros como inhibidores de jak | |
BR112014009190A2 (pt) | formulação, uso de uma formulação, e, processo para a preparação de uma formulação | |
BR112017016817A2 (pt) | derivados heterocíclicos formilados como inibidores de fgfr4 | |
CO2020004669A2 (es) | Derivados de bencimidazol y sus usos | |
MX2020003732A (es) | Derivado de anillo fusionado como inhibidor del receptor a2a. | |
BR112021011325A2 (pt) | Derivados de rapamicina | |
BR112021020297A2 (pt) | Compostos de hexa-hidro-1h-pirazino[1,2-a]pirazina para o tratamento de doença autoimune | |
BR112022001568A2 (pt) | Composto, método para preparação do composto, composição farmacêutica, e, uso do composto | |
BR112022012205A2 (pt) | Compostos ativos para receptores nucleares |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |