BR112022004778A2 - Agente para indução de imunidade específica contra o vírus da síndrome respiratória aguda grave sarscov-2 em forma liofilizada (variantes) e uso - Google Patents

Agente para indução de imunidade específica contra o vírus da síndrome respiratória aguda grave sarscov-2 em forma liofilizada (variantes) e uso

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Publication number
BR112022004778A2
BR112022004778A2 BR112022004778A BR112022004778A BR112022004778A2 BR 112022004778 A2 BR112022004778 A2 BR 112022004778A2 BR 112022004778 A BR112022004778 A BR 112022004778A BR 112022004778 A BR112022004778 A BR 112022004778A BR 112022004778 A2 BR112022004778 A2 BR 112022004778A2
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BR
Brazil
Prior art keywords
seq
agent
acute respiratory
respiratory syndrome
severe acute
Prior art date
Application number
BR112022004778A
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English (en)
Inventor
Vadimovna Zubkova Olga
Andreevna Ozharovskaia Tatiana
Vadimovna Dolzhikova Inna
Popova Olga
Viktorovich Shchebliakov Dmitrii
Mikhailovna Grousova Daria
Shahmirovna Dzharullaeva Alina
Ildarovich Tukhvatulin Amir
Mikhailovna Tukhvatulina Natalia
Nikolaevich Shcherbinin Dmitrii
Bulatovich Esmagambetov Ilias
Alexsandrovna Tokarskaya Elizaveta
Gennadevich Botikov Andrei
Sergeevna Eroxova Alina
Magometovna Izhaeva Fatima
Leonidovna Lubenets Nadezhda
Anatolevna Nikitenko Natalya
Vladimirovich Borisevich Sergey
Sergeevich Semikhin Aleksandr
Yuryevich Logunov Denis
Savelievich Naroditsky Boris
Leonidovich Gintsburg Aleksandr
Original Assignee
Federal State Budgetary Institution National Res Centre For Epidemiology And Microbiology Named Afte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Federal State Budgetary Institution National Res Centre For Epidemiology And Microbiology Named Afte filed Critical Federal State Budgetary Institution National Res Centre For Epidemiology And Microbiology Named Afte
Publication of BR112022004778A2 publication Critical patent/BR112022004778A2/pt

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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/14—Antivirals for RNA viruses
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/543—Mucosal route intranasal
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract

AGENTE PARA INDUÇÃO DE IMUNIDADE ESPECÍFICA CONTRA O VÍRUS DA SÍNDROME RESPIRATÓRIA AGUDA GRAVE SARS-CoV-2 EM FORMA LIOFILIZADA (VARIANTES) E USO. A presente invenção refere-se a um agente de biomolécula para indução de imunidade específica contra o vírus da síndrome respiratória aguda grave SARS-CoV-2, em forma liofilizada (seca por congelamento), que contém um componente ativo único, compreendendo o vetor de expressão incluindo o genoma da cepa recombinante de adenovírus humano sorotipo 26 ou 5, em que as regiões E1 e E3 são deletadas, e um cassete de expressão integrado selecionado de SEQ ID NO: 1, SEQ ID NO: 2 ou SEQ ID NO: 3, ou o genoma da cepa recombinante de adenovírus simiano sorotipo 25, em que as regiões E1 e E3 são deletadas, e um cassete de expressão integrado é selecionado de SEQ ID NO: 4, SEQ ID NO: 2 ou SEQ ID NO: 3. O genoma da cepa recombinante de adenovírus humano sorotipo 26 pode incluir a região ORF6-Ad26 substituída por ORF6-Ad5. A invenção promove respostas imunes humorais e mediadas por células contra o vírus SARS-CoV-2 em amplos estratos da população.
BR112022004778A 2021-02-10 2021-04-30 Agente para indução de imunidade específica contra o vírus da síndrome respiratória aguda grave sarscov-2 em forma liofilizada (variantes) e uso BR112022004778A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2021103101A RU2743962C1 (ru) 2021-02-10 2021-02-10 Средство для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2 в лиофилизированной форме (варианты)
PCT/RU2021/000182 WO2022086364A1 (en) 2021-02-10 2021-04-30 Agent for inducing specific immunity against sars-cov-2

Publications (1)

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BR112022004778A2 true BR112022004778A2 (pt) 2022-08-30

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ID=74857624

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BR112022004778A BR112022004778A2 (pt) 2021-02-10 2021-04-30 Agente para indução de imunidade específica contra o vírus da síndrome respiratória aguda grave sarscov-2 em forma liofilizada (variantes) e uso

Country Status (12)

Country Link
US (1) US20220249655A1 (pt)
EP (1) EP4010477A4 (pt)
JP (1) JP2023501868A (pt)
KR (1) KR20220115918A (pt)
CN (1) CN117730150A (pt)
AR (1) AR126627A1 (pt)
BR (1) BR112022004778A2 (pt)
CA (1) CA3156252A1 (pt)
IL (1) IL291330A (pt)
RU (1) RU2743962C1 (pt)
WO (1) WO2022086364A1 (pt)
ZA (1) ZA202202985B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115160413B (zh) * 2021-04-06 2023-11-14 清华大学 一种新型冠状病毒疫苗

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2021014525A (es) * 2019-05-30 2022-03-17 Gritstone Bio Inc Adenovirus modificados.
CN110974950B (zh) * 2020-03-05 2020-08-07 广州恩宝生物医药科技有限公司 一种用于预防SARS-CoV-2感染的腺病毒载体疫苗
CN111217917B (zh) * 2020-02-26 2020-10-23 康希诺生物股份公司 一种新型冠状病毒SARS-CoV-2疫苗及其制备方法
RU2733834C1 (ru) * 2020-07-28 2020-10-07 Федеральное бюджетное учреждение науки Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Искусственный ген EctoS_SC2, кодирующий эктодомен гликопротеина S коронавируса SARS-CoV-2 с C-концевым тримеризующим доменом, рекомбинантная плазмида pStem-rVSV-EctoS_SC2, обеспечивающая экспрессию искусственного гена, и рекомбинантный штамм вируса везикулярного стоматита rVSV-EctoS_SC2, используемый для создания вакцины против коронавируса SARS-CoV-2
RU2731356C9 (ru) * 2020-08-22 2021-10-05 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Экспрессионный вектор для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2 (варианты)
RU2731342C9 (ru) * 2020-08-22 2021-10-05 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Фармацевтическое средство и способ его использования для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2 (варианты)

Also Published As

Publication number Publication date
WO2022086364A1 (en) 2022-04-28
CA3156252A1 (en) 2022-07-25
KR20220115918A (ko) 2022-08-19
JP2023501868A (ja) 2023-01-20
CN117730150A (zh) 2024-03-19
RU2743962C1 (ru) 2021-03-01
IL291330A (en) 2022-05-01
ZA202202985B (en) 2023-11-29
EP4010477A1 (en) 2022-06-15
US20220249655A1 (en) 2022-08-11
AR126627A1 (es) 2023-11-01
EP4010477A4 (en) 2022-12-14

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