BR112022001654A2 - CONJUGATED COMPOSITIONS OF MULTIVALENT PNEUMOCOCCUS POLYSACCHARIDE PROTEINS AND METHODS OF USE THEREOF - Google Patents

CONJUGATED COMPOSITIONS OF MULTIVALENT PNEUMOCOCCUS POLYSACCHARIDE PROTEINS AND METHODS OF USE THEREOF

Info

Publication number
BR112022001654A2
BR112022001654A2 BR112022001654A BR112022001654A BR112022001654A2 BR 112022001654 A2 BR112022001654 A2 BR 112022001654A2 BR 112022001654 A BR112022001654 A BR 112022001654A BR 112022001654 A BR112022001654 A BR 112022001654A BR 112022001654 A2 BR112022001654 A2 BR 112022001654A2
Authority
BR
Brazil
Prior art keywords
methods
polysaccharide
compositions
multivalent
streptococcus pneumoniae
Prior art date
Application number
BR112022001654A
Other languages
Portuguese (pt)
Inventor
Shin Inhwan
Kim Sunghyun
Kim Hun
An Kyungjun
Lee Jeong-Min
Kyaw Moe
TALAGA Philippe
Original Assignee
Sanofi Pasteur Inc
Sk Bioscience Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Pasteur Inc, Sk Bioscience Co Ltd filed Critical Sanofi Pasteur Inc
Publication of BR112022001654A2 publication Critical patent/BR112022001654A2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

Abstract

COMPOSIÇÕES CONJUGADAS DE PROTEÍNAS DE POLISSACARÍDEOS PNEUMOCÓCICOS MULTIVALENTES E MÉTODOS DE UTILIZAÇÃO DOS MESMOS. A presente invenção refere-se a composições conjugadas pneumocócicas multivalentes compreendendo 22-27 conjugados polissacarídeos capsulares pneumocócicos diferentes, em que cada polissacarídeo capsular pneumocócico conjugado compreende um portador de proteína conjugado a um polissacarídeo capsular de um sorótipo diferente de Streptococcus pneumoniae, em que os serótipos de Streptococcus pneumoniae são selecionados entre 1, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15A, 15B, 15C, 18C, 19A, 19F, 22F, 23A, 23B, 23F, 24F, 33F, e 35B. Também são fornecidos métodos de produção das composições conjugadas pneumocócicas multivalentes e métodos de uso do mesmo para a profilaxia contra a infecção ou doença por Streptococcus pneumoniae em um indivíduo. Também são fornecidas composições imunogênicas compreendendo pelo menos um conjugado polissacarídeo-proteína em que o polissacarídeo é um polissacarídeo capsular de Streptococcus pneumoniae serótipo 15A, 15C, 23A, 23B, 24F, e/ou 35B e métodos de preparação do mesmo.CONJUGATED COMPOSITIONS OF MULTIVALENT PNEUMOCOCCUS POLYSACCHARIDE PROTEINS AND METHODS OF USE THEREOF. The present invention relates to multivalent pneumococcal conjugate compositions comprising 22-27 different pneumococcal capsular polysaccharide conjugates, wherein each pneumococcal capsular polysaccharide conjugate comprises a protein carrier conjugated to a capsular polysaccharide of a different serotype of Streptococcus pneumoniae, wherein the serotypes of Streptococcus pneumoniae are selected from 1, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15A, 15B, 15C, 18C, 19A, 19F, 22F, 23A, 23B, 23F, 24F, 33F, and 35B. Also provided are methods of making the multivalent pneumococcal conjugate compositions and methods of using the same for prophylaxis against Streptococcus pneumoniae infection or disease in a subject. Immunogenic compositions comprising at least one polysaccharide-protein conjugate wherein the polysaccharide is a Streptococcus pneumoniae serotype 15A, 15C, 23A, 23B, 24F, and/or 35B capsular polysaccharide and methods of preparing the same are also provided.

BR112022001654A 2019-07-31 2020-07-27 CONJUGATED COMPOSITIONS OF MULTIVALENT PNEUMOCOCCUS POLYSACCHARIDE PROTEINS AND METHODS OF USE THEREOF BR112022001654A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20190093276 2019-07-31
US201962949164P 2019-12-17 2019-12-17
PCT/US2020/043729 WO2021021729A1 (en) 2019-07-31 2020-07-27 Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same

Publications (1)

Publication Number Publication Date
BR112022001654A2 true BR112022001654A2 (en) 2022-07-12

Family

ID=72047139

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022001654A BR112022001654A2 (en) 2019-07-31 2020-07-27 CONJUGATED COMPOSITIONS OF MULTIVALENT PNEUMOCOCCUS POLYSACCHARIDE PROTEINS AND METHODS OF USE THEREOF

Country Status (12)

Country Link
US (1) US20220265803A1 (en)
EP (1) EP4003410A1 (en)
JP (1) JP2022542316A (en)
KR (1) KR20220042378A (en)
CN (1) CN114728050A (en)
AU (1) AU2020323498A1 (en)
BR (1) BR112022001654A2 (en)
CA (1) CA3148824A1 (en)
IL (1) IL290182A (en)
MX (1) MX2022001241A (en)
TW (1) TW202106332A (en)
WO (1) WO2021021729A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018027123A1 (en) 2016-08-05 2018-02-08 Sanofi Pasteur, Inc. Multivalent pneumococcal polysaccharide-protein conjugate composition
BR112019001971A2 (en) 2016-08-05 2019-05-07 Sanofi Pasteur, Inc. multivalent pneumococcal polysaccharide-protein conjugate composition
WO2018144438A1 (en) 2017-01-31 2018-08-09 Merck Sharp & Dohme Corp. Methods for production of capsular polysaccharide protein conjugates from streptococcus pneumoniae serotype 19f
MA51049A (en) 2017-12-06 2020-10-14 Merck Sharp & Dohme COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF
CA3087572A1 (en) 2018-02-05 2019-08-08 Sanofi Pasteur Inc. Multivalent pneumococcal polysaccharide-protein conjugate composition
MX2020008198A (en) 2018-02-05 2020-09-22 Sanofi Pasteur Inc Multivalent pneumococcal polysaccharide-protein conjugate composition.
CA3096358A1 (en) 2018-04-18 2019-10-24 Sk Bioscience Co., Ltd. Streptococcus pneumoniae capsular polysaccharide and immunogenic conjugate thereof
BR112021011961A8 (en) 2018-12-19 2023-02-07 Merck Sharp & Dohme COMPOSITIONS COMPRISING POLYSACCHARIDE-PROTEIN CONJUGATES OF STREPTOCOCCUS PNEUMONIAE AND METHODS OF USE THEREOF
CN116942804A (en) * 2022-04-19 2023-10-27 上海瑞宙生物科技有限公司 Component of multivalent pneumococcal polysaccharide conjugate vaccine and application thereof

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027888B1 (en) 1979-09-21 1986-04-16 Hitachi, Ltd. Semiconductor switch
US4270537A (en) 1979-11-19 1981-06-02 Romaine Richard A Automatic hypodermic syringe
US4902506A (en) 1983-07-05 1990-02-20 The University Of Rochester Immunogenic conjugates
US4673574A (en) 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4709017A (en) 1985-06-07 1987-11-24 President And Fellows Of Harvard College Modified toxic vaccines
CA1283827C (en) 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
GB8704027D0 (en) 1987-02-20 1987-03-25 Owen Mumford Ltd Syringe needle combination
US4950740A (en) 1987-03-17 1990-08-21 Cetus Corporation Recombinant diphtheria vaccines
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US4940460A (en) 1987-06-19 1990-07-10 Bioject, Inc. Patient-fillable and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US5339163A (en) 1988-03-16 1994-08-16 Canon Kabushiki Kaisha Automatic exposure control device using plural image plane detection areas
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
FR2638359A1 (en) 1988-11-03 1990-05-04 Tino Dalto SYRINGE GUIDE WITH ADJUSTMENT OF DEPTH DEPTH OF NEEDLE IN SKIN
DE3841091A1 (en) 1988-12-07 1990-06-13 Behringwerke Ag SYNTHETIC ANTIGENS, METHOD FOR THEIR PRODUCTION AND THEIR USE
ES2055785T3 (en) 1989-01-17 1994-09-01 Eniricerche Spa SYNTHETIC PEPTIDES AND THEIR USE AS UNIVERSAL VEHICLES FOR THE PREPARATION OF IMMUNOGENOUS CONJUGATES SUITABLE FOR THE DEVELOPMENT OF SYNTHETIC VACCINES.
WO1990014837A1 (en) 1989-05-25 1990-12-13 Chiron Corporation Adjuvant formulation comprising a submicron oil droplet emulsion
CA2063271A1 (en) 1989-07-14 1991-01-15 Subramonia Pillai Cytokine and hormone carriers for conjugate vaccines
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
IT1237764B (en) 1989-11-10 1993-06-17 Eniricerche Spa SYNTHETIC PEPTIDES USEFUL AS UNIVERSAL CARRIERS FOR THE PREPARATION OF IMMUNOGENIC CONJUGATES AND THEIR USE FOR THE DEVELOPMENT OF SYNTHETIC VACCINES.
SE466259B (en) 1990-05-31 1992-01-20 Arne Forsgren PROTEIN D - AN IGD BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE, AND THE USE OF THIS FOR ANALYSIS, VACCINES AND PURPOSE
IL98715A0 (en) 1990-08-13 1992-07-15 American Cyanamid Co Filamentous hemaglutinin of bodetella pertussis as a carrier molecule for conjugate vaccines
US5190521A (en) 1990-08-22 1993-03-02 Tecnol Medical Products, Inc. Apparatus and method for raising a skin wheal and anesthetizing skin
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
CA2059693C (en) 1991-01-28 2003-08-19 Peter J. Kniskern Polysaccharide antigens from streptococcus pneumoniae
IL101715A (en) 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs
GB9118204D0 (en) 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
SE9102652D0 (en) 1991-09-13 1991-09-13 Kabi Pharmacia Ab INJECTION NEEDLE ARRANGEMENT
JPH07507854A (en) 1991-12-23 1995-08-31 ツォッヒェ，ミヒャエル Engine with oil removal device
DE69333107T2 (en) 1992-02-11 2004-01-29 Jackson H M Found Military Med DUAL SUPPORT FOR IMMUNOGENIC CONSTRUCTS
US5328483A (en) 1992-02-27 1994-07-12 Jacoby Richard M Intradermal injection device with medication and needle guard
IT1262896B (en) 1992-03-06 1996-07-22 CONJUGATE COMPOUNDS FORMED FROM HEAT SHOCK PROTEIN (HSP) AND OLIGO-POLY-SACCHARIDES, THEIR USE FOR THE PRODUCTION OF VACCINES.
JP3506431B2 (en) 1992-05-06 2004-03-15 プレジデント アンド フェローズ オブ ハーバード カレッジ Diphtheria toxin receptor binding domain
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
IL102687A (en) 1992-07-30 1997-06-10 Yeda Res & Dev Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
US5334144A (en) 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
ES2231770T3 (en) 1993-03-05 2005-05-16 Wyeth Holdings Corporation NEW PLASMIDS FOR THE PRODUCTION OF CRM PROTEIN AND DIFTERIC TOXIN.
ATE254475T1 (en) 1993-09-22 2003-12-15 Jackson H M Found Military Med METHOD FOR ACTIVATION OF SOLUBLE CARBOHYDRATES BY USING NEW CYANYLATION REAGENTS TO PRODUCE IMMUNOGENIC CONSTRUCTS
WO1995024176A1 (en) 1994-03-07 1995-09-14 Bioject, Inc. Ampule filling device
US5466220A (en) 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US6455673B1 (en) 1994-06-08 2002-09-24 President And Fellows Of Harvard College Multi-mutant diphtheria toxin vaccines
US5917017A (en) 1994-06-08 1999-06-29 President And Fellows Of Harvard College Diphtheria toxin vaccines bearing a mutated R domain
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
AU4986596A (en) 1995-02-16 1996-09-04 Massachusetts Health Research Institute, Inc. Purified tetanus toxoid and toxin
ATE241384T1 (en) 1995-03-22 2003-06-15 Jackson H M Found Military Med PREPARATION OF IMMUNOGENIC CONSTRUCTS USING SOLUBLE CARBOHYDRATES ACTIVATED BY ORGANIC CYANYLATION REAGENTS
US5730723A (en) 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
US5893397A (en) 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
GB9607549D0 (en) 1996-04-11 1996-06-12 Weston Medical Ltd Spring-powered dispensing device
US6299881B1 (en) 1997-03-24 2001-10-09 Henry M. Jackson Foundation For The Advancement Of Military Medicine Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts
US6113918A (en) 1997-05-08 2000-09-05 Ribi Immunochem Research, Inc. Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
US5993412A (en) 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
GB9713156D0 (en) 1997-06-20 1997-08-27 Microbiological Res Authority Vaccines
IT1298087B1 (en) 1998-01-08 1999-12-20 Fiderm S R L DEVICE FOR CHECKING THE PENETRATION DEPTH OF A NEEDLE, IN PARTICULAR APPLICABLE TO A SYRINGE FOR INJECTIONS
CA2344740C (en) 1998-09-30 2011-11-22 American Cyanamid Company Mutant cholera holotoxin as an adjuvant
CA2355364C (en) 1998-12-21 2014-03-18 Medimmune, Inc. Streptococcus pneumoniae proteins and immunogenic fragments for vaccines
CZ303675B6 (en) 1998-12-23 2013-02-27 Id Biomedical Corporation Of Quebec Isolated polynucleotide, vector, host cell, production process, isolated polypeptide, chimeric polypeptide, vaccine composition and use
WO2000061761A2 (en) 1999-04-09 2000-10-19 Techlab, Inc. Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
GB0007432D0 (en) 2000-03-27 2000-05-17 Microbiological Res Authority Proteins for use as carriers in conjugate vaccines
JP5051959B2 (en) 2000-06-20 2012-10-17 アイディー バイオメディカル コーポレイション オブ ケベック Streptococcus antigen
DE60144198D1 (en) 2000-12-28 2011-04-21 Wyeth Llc RECOMBINANT PROTECTION PROTEIN FROM STREPTOCOCCUS PNEUMONIAE
EP2278013A1 (en) 2001-04-16 2011-01-26 Wyeth Holdings Corporation Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof
WO2002091998A2 (en) 2001-05-11 2002-11-21 Aventis Pasteur, Inc. Novel meningitis conjugate vaccine
WO2002098369A2 (en) 2001-06-07 2002-12-12 Wyeth Holdings Corporation Mutant forms of cholera holotoxin as an adjuvant
ATE451386T1 (en) 2001-06-07 2009-12-15 Wyeth Corp MUTANT FORMS OF CHOLERA HOLOTOXIN AS ADJUVANTS
EP1456231A2 (en) 2001-12-20 2004-09-15 Shire Biochem Inc. Streptococcus antigens
NZ541969A (en) 2003-03-13 2008-01-31 Glaxosmithkline Biolog Sa Purifying pneumolysin from Streptococcus pneumoniae in a single chromatographic step by binding it to a hydrophobic interaction column in the presence of detergent and high salt
EP1603950A2 (en) 2003-03-17 2005-12-14 Wyeth Holdings Corporation Mutant cholera holotoxin as an adjuvant and an antigen carrier protein
GB0421083D0 (en) 2004-09-22 2004-10-27 Glaxosmithkline Biolog Sa Purification process
US7709001B2 (en) 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
US20070184072A1 (en) 2005-04-08 2007-08-09 Wyeth Multivalent pneumococcal polysaccharide-protein conjugate composition
PL3466982T3 (en) 2005-04-08 2020-11-02 Wyeth Llc Separation of contaminants from streptococcus pneumoniae polysaccharide by ph manipulation
IL308456A (en) 2005-04-08 2024-01-01 Wyeth Llc Multivalent pneumococcal polysacharide-protein conjugate composition
US7955605B2 (en) 2005-04-08 2011-06-07 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
ATE473289T1 (en) 2006-10-10 2010-07-15 Wyeth Llc IMPROVED METHODS FOR SEPARATION OF STREPTOCOCCUS PNEUMONIAE-3-POLYSACCHARIDES
SI2436700T1 (en) 2007-03-23 2018-09-28 Wyeth Llc Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides
KR101579947B1 (en) 2007-06-26 2015-12-28 글락소스미스클라인 바이오로지칼즈 에스.에이. Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates
TW201136603A (en) 2010-02-09 2011-11-01 Merck Sharp & Amp Dohme Corp 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition
KR102057217B1 (en) 2012-06-20 2020-01-22 에스케이바이오사이언스 주식회사 Multivalent pneumococcal polysaccharide-protein conjugate composition
US20160324949A1 (en) * 2014-01-21 2016-11-10 Pfizer Inc. Streptococcus pneumoniae capsular polysaccharides and conjugates thereof
CN114887048A (en) * 2014-01-21 2022-08-12 辉瑞公司 Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
WO2018027123A1 (en) 2016-08-05 2018-02-08 Sanofi Pasteur, Inc. Multivalent pneumococcal polysaccharide-protein conjugate composition
BR112019001971A2 (en) 2016-08-05 2019-05-07 Sanofi Pasteur, Inc. multivalent pneumococcal polysaccharide-protein conjugate composition
IL265623B2 (en) * 2016-09-30 2023-04-01 Biological E Ltd Multivalent pneumococcal vaccine compositions comprising polysaccharide-protein conjugates
MA51049A (en) 2017-12-06 2020-10-14 Merck Sharp & Dohme COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF
MX2020008198A (en) 2018-02-05 2020-09-22 Sanofi Pasteur Inc Multivalent pneumococcal polysaccharide-protein conjugate composition.
CA3087572A1 (en) 2018-02-05 2019-08-08 Sanofi Pasteur Inc. Multivalent pneumococcal polysaccharide-protein conjugate composition

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WO2021021729A1 (en) 2021-02-04
US20220265803A1 (en) 2022-08-25
TW202106332A (en) 2021-02-16
IL290182A (en) 2022-03-01
AU2020323498A1 (en) 2022-03-03
JP2022542316A (en) 2022-09-30
EP4003410A1 (en) 2022-06-01
MX2022001241A (en) 2022-04-20
CA3148824A1 (en) 2021-02-04
CN114728050A (en) 2022-07-08
KR20220042378A (en) 2022-04-05

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