BR112021026616A2 - Composições de exenatidas para administração pulmonar e uso das mesmas - Google Patents

Composições de exenatidas para administração pulmonar e uso das mesmas

Info

Publication number
BR112021026616A2
BR112021026616A2 BR112021026616A BR112021026616A BR112021026616A2 BR 112021026616 A2 BR112021026616 A2 BR 112021026616A2 BR 112021026616 A BR112021026616 A BR 112021026616A BR 112021026616 A BR112021026616 A BR 112021026616A BR 112021026616 A2 BR112021026616 A2 BR 112021026616A2
Authority
BR
Brazil
Prior art keywords
pulmonary administration
exenatide
compositions
exenatide compositions
administration
Prior art date
Application number
BR112021026616A
Other languages
English (en)
Inventor
Benjamin Stedman
Blaine Bueche
Ian Chan
John Patton
Mei-Chang Kuo
Original Assignee
Aerami Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aerami Therapeutics Inc filed Critical Aerami Therapeutics Inc
Publication of BR112021026616A2 publication Critical patent/BR112021026616A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

composições de exenatidas para administração pulmonar e uso das mesmas. são fornecidas neste documento composições farmacêuticas que compreendem exenatida e um tampão aquoso, em que as composições farmacêuticas são embaladas para administração por inalação. métodos para o tratamento de diabetes mellitus também são descritos.
BR112021026616A 2019-07-03 2020-07-01 Composições de exenatidas para administração pulmonar e uso das mesmas BR112021026616A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962870447P 2019-07-03 2019-07-03
PCT/US2020/040513 WO2021003277A1 (en) 2019-07-03 2020-07-01 Exenatide compositions for pulmonary administration and use thereof

Publications (1)

Publication Number Publication Date
BR112021026616A2 true BR112021026616A2 (pt) 2022-02-15

Family

ID=71944269

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021026616A BR112021026616A2 (pt) 2019-07-03 2020-07-01 Composições de exenatidas para administração pulmonar e uso das mesmas

Country Status (5)

Country Link
US (1) US20220249618A1 (pt)
EP (1) EP3993774A1 (pt)
CN (1) CN114269369A (pt)
BR (1) BR112021026616A2 (pt)
WO (1) WO2021003277A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115845031A (zh) * 2021-09-24 2023-03-28 派格生物医药(苏州)股份有限公司 一种含有聚乙二醇化艾塞那肽变体的药物组合物及其用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6211144B1 (en) 1998-10-16 2001-04-03 Novo Nordisk A/S Stable concentrated insulin preparations for pulmonary delivery
US6489292B1 (en) 1998-11-18 2002-12-03 Novo Nordisk A/S Stable aqueous insulin preparations without phenol and cresol
US20030087820A1 (en) * 1999-01-14 2003-05-08 Young Andrew A. Novel exendin agonist formulations and methods of administration thereof
US20080318861A1 (en) * 2005-12-08 2008-12-25 Nastech Pharmaceutical Company Inc. Mucosal Delivery of Stabilized Formulations of Exendin
RU2413528C2 (ru) * 2007-01-18 2011-03-10 Открытое Акционерное Общество "Валента Фармацевтика" Лекарственный препарат для лечения сахарного диабета на основе экзенатида и даларгина, применение и способ лечения
CN101366692A (zh) * 2007-08-15 2009-02-18 江苏豪森药业股份有限公司 一种稳定的艾塞那肽制剂
CN101606903A (zh) * 2008-06-19 2009-12-23 北京韩美药品有限公司 一种氨溴索的雾化吸入用溶液剂及其制备方法
US9163883B2 (en) 2009-03-06 2015-10-20 Kevlin Thermal Technologies, Inc. Flexible thermal ground plane and manufacturing the same
US9180261B2 (en) 2010-01-12 2015-11-10 Dance Biopharm Inc. Preservative free insulin formulations and systems and methods for aerosolizing
US20130269684A1 (en) 2012-04-16 2013-10-17 Dance Pharmaceuticals, Inc. Methods and systems for supplying aerosolization devices with liquid medicaments
US20130269694A1 (en) 2012-04-16 2013-10-17 Dance Pharmaceuticals, Inc. Inhaler controlled by mobile device
CN104027326B (zh) * 2013-03-04 2017-09-01 天津康鸿医药科技发展有限公司 盐酸氨溴索雾化吸入剂及其制备方法和应用
RU2669930C2 (ru) 2013-04-16 2018-10-17 Данс Байофарм Инк. Дозирование жидкостей и способы дозирования жидкостей
US10610651B2 (en) 2014-06-09 2020-04-07 Aerami Therapeutics, Inc. Self-puncturing liquid drug cartridges and associated dispenser
US10471222B2 (en) 2014-07-01 2019-11-12 Dance Biopharm Inc. Aerosolization system with flow restrictor and feedback device
US10857313B2 (en) 2014-07-01 2020-12-08 Aerami Therapeutics, Inc. Liquid nebulization systems and methods

Also Published As

Publication number Publication date
WO2021003277A1 (en) 2021-01-07
EP3993774A1 (en) 2022-05-11
CN114269369A (zh) 2022-04-01
US20220249618A1 (en) 2022-08-11

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]