BR112021025390A2 - Métodos para prever a responsividade ao fármaco em pacientes com câncer - Google Patents
Métodos para prever a responsividade ao fármaco em pacientes com câncerInfo
- Publication number
- BR112021025390A2 BR112021025390A2 BR112021025390A BR112021025390A BR112021025390A2 BR 112021025390 A2 BR112021025390 A2 BR 112021025390A2 BR 112021025390 A BR112021025390 A BR 112021025390A BR 112021025390 A BR112021025390 A BR 112021025390A BR 112021025390 A2 BR112021025390 A2 BR 112021025390A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- treatment
- cancer patients
- drug responsiveness
- predict drug
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 201000011510 cancer Diseases 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 230000004043 responsiveness Effects 0.000 title abstract 2
- KCOYQXZDFIIGCY-CZIZESTLSA-N (3e)-4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one Chemical compound C1CN(C)CCN1C1=CC=C(N\C(N2)=C/3C(=C4C(F)=CC=CC4=NC\3=O)N)C2=C1 KCOYQXZDFIIGCY-CZIZESTLSA-N 0.000 abstract 2
- 229950005778 dovitinib Drugs 0.000 abstract 2
- 230000014509 gene expression Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000090 biomarker Substances 0.000 abstract 1
- 230000004044 response Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Medical Informatics (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
Abstract
métodos para prever a responsividade ao fármaco em pacientes com câncer. a presente invenção apresenta métodos, dispositivos e kits para detectar a expressão gênica em um paciente com câncer ou determinar a resposta de um paciente com câncer a um tratamento, como o tratamen-to com dovitinibe ou um sal farmaceuticamente aceitável do mesmo. a invenção inclui ainda métodos de tratamento de um paciente com câncer pela administração de um tratamento, por exemplo, tratamento com dovitinibe ou um sal farmaceuticamente aceitável do mesmo, em particular quando o paciente é determinado como sendo responsivo ao tratamento com base na expressão dos biomarcadores descritos no presente documento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/444,881 US10835531B1 (en) | 2019-06-18 | 2019-06-18 | Methods for predicting drug responsiveness in cancer patients |
PCT/EP2020/066724 WO2020254383A1 (en) | 2019-06-18 | 2020-06-17 | Methods for predicting drug responsiveness in cancer patients |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112021025390A2 true BR112021025390A2 (pt) | 2022-02-01 |
BR112021025390A8 BR112021025390A8 (pt) | 2022-11-08 |
Family
ID=71105475
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021025390A BR112021025390A8 (pt) | 2019-06-18 | 2020-06-17 | Métodos para prever a responsividade ao fármaco em pacientes com câncer |
Country Status (9)
Country | Link |
---|---|
US (2) | US10835531B1 (pt) |
EP (1) | EP3987063A1 (pt) |
JP (1) | JP2022537265A (pt) |
CN (1) | CN114258432A (pt) |
AU (1) | AU2020294893A1 (pt) |
BR (1) | BR112021025390A8 (pt) |
CA (1) | CA3142558A1 (pt) |
MX (1) | MX2021015717A (pt) |
WO (1) | WO2020254383A1 (pt) |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5956501A (en) | 1997-01-10 | 1999-09-21 | Health Hero Network, Inc. | Disease simulation system and method |
US20020006613A1 (en) | 1998-01-20 | 2002-01-17 | Shyjan Andrew W. | Methods and compositions for the identification and assessment of cancer therapies |
US7324926B2 (en) | 1999-04-09 | 2008-01-29 | Whitehead Institute For Biomedical Research | Methods for predicting chemosensitivity or chemoresistance |
US20020120004A1 (en) | 2000-02-17 | 2002-08-29 | Roth Frederick P. | Methods and compositions for the identification, assessment, prevention and therapy of human cancers |
SG174632A1 (en) | 2000-09-11 | 2011-10-28 | Novartis Vaccines & Diagnostic | Quinolinone derivatives |
WO2005032347A2 (en) | 2003-10-01 | 2005-04-14 | The Ohio State University Research Foundation | Determining the chemosensitivity of cells to cytotoxic agents |
US7879545B2 (en) | 2003-11-05 | 2011-02-01 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Identification of novel targets for radio sensitization using a genomic-based radiation sensitivity classifier |
US20050227266A1 (en) | 2004-02-06 | 2005-10-13 | Ross Douglas T | Biomarker:compound correlations in cancer diagnosis and therapy |
JP2009523410A (ja) * | 2005-12-08 | 2009-06-25 | ノバルティス アクチエンゲゼルシャフト | 遺伝子転写に対するfgfr3の阻害剤の効果 |
CA2785529C (en) | 2010-02-11 | 2019-01-08 | Nanostring Technologies, Inc. | Compositions and methods for the detection of small rnas |
WO2011116088A2 (en) | 2010-03-16 | 2011-09-22 | Nanostring Technologies, Inc. | Compositions and methods for the detection of genomic features |
UY33472A (es) | 2010-06-30 | 2012-01-31 | Novartis Ag | ?composiciones farmacéuticas que comprenden monohidrato de lactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1hbencimidazol-2-il]-1h-quinolin-2-ona?. |
EP2723897A4 (en) | 2011-06-24 | 2015-03-18 | Nanostring Technologies Inc | MULTIVARIATED DIAGNOSTIC ASSAYS AND METHODS OF USE THEREOF |
US20150320754A1 (en) * | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
-
2019
- 2019-06-18 US US16/444,881 patent/US10835531B1/en active Active
-
2020
- 2020-06-17 CA CA3142558A patent/CA3142558A1/en active Pending
- 2020-06-17 MX MX2021015717A patent/MX2021015717A/es unknown
- 2020-06-17 US US17/596,711 patent/US20220362240A1/en active Pending
- 2020-06-17 EP EP20733593.6A patent/EP3987063A1/en active Pending
- 2020-06-17 AU AU2020294893A patent/AU2020294893A1/en not_active Abandoned
- 2020-06-17 BR BR112021025390A patent/BR112021025390A8/pt unknown
- 2020-06-17 JP JP2021572630A patent/JP2022537265A/ja active Pending
- 2020-06-17 CN CN202080058332.9A patent/CN114258432A/zh active Pending
- 2020-06-17 WO PCT/EP2020/066724 patent/WO2020254383A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR112021025390A8 (pt) | 2022-11-08 |
US20220362240A1 (en) | 2022-11-17 |
MX2021015717A (es) | 2022-04-11 |
CA3142558A1 (en) | 2020-12-24 |
EP3987063A1 (en) | 2022-04-27 |
WO2020254383A1 (en) | 2020-12-24 |
JP2022537265A (ja) | 2022-08-25 |
US10835531B1 (en) | 2020-11-17 |
AU2020294893A1 (en) | 2021-12-09 |
CN114258432A (zh) | 2022-03-29 |
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