BR112021025192A2 - Forma de dosagem oral sólida de liberação prolongada compreendendo vitamina b12 e um medicamento que elimina a vitamina b12 - Google Patents

Forma de dosagem oral sólida de liberação prolongada compreendendo vitamina b12 e um medicamento que elimina a vitamina b12

Info

Publication number
BR112021025192A2
BR112021025192A2 BR112021025192A BR112021025192A BR112021025192A2 BR 112021025192 A2 BR112021025192 A2 BR 112021025192A2 BR 112021025192 A BR112021025192 A BR 112021025192A BR 112021025192 A BR112021025192 A BR 112021025192A BR 112021025192 A2 BR112021025192 A2 BR 112021025192A2
Authority
BR
Brazil
Prior art keywords
vitamin
drug
extended
dosage form
oral dosage
Prior art date
Application number
BR112021025192A
Other languages
English (en)
Inventor
Andreas Niederquell
Thomas Kuentz Martin
Ralph Schneiter
Zdravka Misic
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BR112021025192A2 publication Critical patent/BR112021025192A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

forma de dosagem oral sólida de liberação prolongada compreendendo vitamina b12 e um medicamento que elimina a vitamina b12. a presente invenção se refere a uma forma de dosagem oral sólida compreendendo um núcleo de comprimido de liberação prolongada que é revestido com um revestimento de liberação imediata, em que o referido núcleo de comprimido de liberação prolongada compreende pelo menos um fármaco que elimina a vitamina b12 e em que o referido revestimento de liberação imediata compreende vitamina b12 ou uma formulação seca por pulverização da mesma. em uma modalidade preferida, o fármaco que elimina a vitamina b12 é a metformina ou um sal farmaceuticamente aceitável do mesmo.
BR112021025192A 2019-06-17 2020-06-17 Forma de dosagem oral sólida de liberação prolongada compreendendo vitamina b12 e um medicamento que elimina a vitamina b12 BR112021025192A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19180447 2019-06-17
PCT/EP2020/066757 WO2020254401A1 (en) 2019-06-17 2020-06-17 Extended-release solid oral dosage form comprising vitamin b12 and a vitamin b12 depleting drug

Publications (1)

Publication Number Publication Date
BR112021025192A2 true BR112021025192A2 (pt) 2022-02-01

Family

ID=66912631

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021025192A BR112021025192A2 (pt) 2019-06-17 2020-06-17 Forma de dosagem oral sólida de liberação prolongada compreendendo vitamina b12 e um medicamento que elimina a vitamina b12

Country Status (7)

Country Link
US (1) US20220241207A1 (pt)
EP (1) EP3982938A1 (pt)
JP (1) JP2022537107A (pt)
KR (1) KR20220024560A (pt)
CN (1) CN114007592A (pt)
BR (1) BR112021025192A2 (pt)
WO (1) WO2020254401A1 (pt)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA739588B (en) * 1973-01-18 1974-11-27 Hoffmann La Roche Stabilized powder
US9884024B2 (en) * 2005-12-27 2018-02-06 Hemant N Joshi Physically dispersed, molecularly dissolved and/or chemically bound drug(s) in an empty, hard capsule shell composition
WO2011149337A1 (en) * 2010-05-28 2011-12-01 Bethesda Diabetes Research Centrum B.V. New combination treatment for type 2 diabetes and other disorders related to insulin resistance
PT2938362T (pt) 2012-12-27 2017-03-06 Zentiva Saglik Ürünleri San Ve Tic A S Processo de granulação por via seca para produzir composições de comprimidos de metformina e composições associadas
EP2996680A1 (en) * 2013-03-28 2016-03-23 Wockhardt Limited Solid oral pharmaceutical compositions comprising fixed dose combination of metformin and sitagliptin or salts thereof
WO2017093419A1 (en) * 2015-12-04 2017-06-08 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof

Also Published As

Publication number Publication date
JP2022537107A (ja) 2022-08-24
CN114007592A (zh) 2022-02-01
WO2020254401A1 (en) 2020-12-24
US20220241207A1 (en) 2022-08-04
KR20220024560A (ko) 2022-03-03
EP3982938A1 (en) 2022-04-20

Similar Documents

Publication Publication Date Title
BRPI0620863A8 (pt) comprimido em camadas com combinação de liberação tripla
BR112012024019A2 (pt) forma de dosagem de liberação controlada, e, método para liberar uma droga
BR112017014067A2 (pt) composição para tratar doenças relacionadas a il-6
CL2021001810A1 (es) Combinación de dextrometorfano y bupropión para el tratamiento de depresión
AR079208A2 (es) Inhibidores de la actividad de proteina tirosina quinasa, composicion y uso de dichos inhibidores para la preparacion de un medicamento para tratar una enfermedad, trastorno o condicion oftalmica
MX2020007625A (es) Inhibidor mtor, composicion farmaceutica y su uso.
ES2421929T3 (es) Nueva forma de administración de racecadotrilo
BRPI0719395C1 (pt) tablete revestido de filme
HRP20150260T1 (hr) Uporaba biotina za lijeäśenje multiple skleroze
BRPI0513598A (pt) formas de dosagem em comprimidos revestidos de liberação entérica
CO2017010510A2 (es) Tableta de ribociclib
BR112014014795A2 (pt) sistema de pélete de multiunidade de liberação imediata
BR112022003434A2 (pt) Composição de liberação retardada de niclosamida e uso antiviral da mesma
GT200900089A (es) Composicion farmaceutica en forma de microesferas recubiertas para la liberacion modificada de un relajante muscular y un aine
AR115913A1 (es) Formas de dosificación oral biodisponibles, uso, métodos
AR092356A1 (es) Formulacion compuesta para administracion oral que comprende metformina y rosuvastatina y metodo de preparacion de la formulacion
BR112021025192A2 (pt) Forma de dosagem oral sólida de liberação prolongada compreendendo vitamina b12 e um medicamento que elimina a vitamina b12
BR112022002436A2 (pt) Composição farmacêutica oral contendo composto heterocíclico
BR112018068784A2 (pt) método para o tratamento de leucemia
TR201913472A2 (tr) Vi̇ldagli̇pti̇n ve metformi̇n i̇çeren bi̇r kombi̇nasyon
CO6290082A1 (es) Composicion farmaceutica oral que comprende la combinacion de una sal de ketorolaco y vitaminas del complejo b
CL2008003062A1 (es) Compuestos derivados de pirazoles espiro conjugados, inhibidores de la actividad de ksp kinesina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de enfermedades proliferativas.
BR112022019864A2 (pt) Composto de oxofenilarsina deuterada e uso do mesmo
ECSP16005208A (es) Composición farmacéutica anti-tuberculosis estable en una forma de un comprimido recubierto que comprende gránulos de isoniazid y gránulos de rifapentina y su proceso de preparación
RS53033B (en) VILDAGLIPTIN AND GLIMEPIRID COMBINATIONS

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]