BR112021024886A2 - Métodos de tratar a doença de fabry em pacientes com insuficiência renal - Google Patents
Métodos de tratar a doença de fabry em pacientes com insuficiência renalInfo
- Publication number
- BR112021024886A2 BR112021024886A2 BR112021024886A BR112021024886A BR112021024886A2 BR 112021024886 A2 BR112021024886 A2 BR 112021024886A2 BR 112021024886 A BR112021024886 A BR 112021024886A BR 112021024886 A BR112021024886 A BR 112021024886A BR 112021024886 A2 BR112021024886 A2 BR 112021024886A2
- Authority
- BR
- Brazil
- Prior art keywords
- disease
- methods
- renal failure
- patients
- treating fabry
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01022—Alpha-galactosidase (3.2.1.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
métodos de tratar a doença de fabry em pacientes com insuficiência renal. são fornecidos métodos para o tratamento da doença de fabry em um paciente com insuficiência renal. certos métodos compreendem administrar ao paciente cerca de 100 mg a cerca de 300 mg equivalentes de base livre de migalastate ou sal deste a uma frequência superior a uma vez a cada dois dias, tal como uma vez a cada quatro ou sete dias. certos métodos compreendem medir lyso-gb3 e/ou migalastate em uma ou mais amostras de plasma do paciente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962859904P | 2019-06-11 | 2019-06-11 | |
| PCT/US2020/037174 WO2020252129A1 (en) | 2019-06-11 | 2020-06-11 | Methods of treating fabry disease in patients having renal impairment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021024886A2 true BR112021024886A2 (pt) | 2022-01-25 |
Family
ID=71950725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021024886A BR112021024886A2 (pt) | 2019-06-11 | 2020-06-11 | Métodos de tratar a doença de fabry em pacientes com insuficiência renal |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20220313670A1 (pt) |
| EP (1) | EP3982962A1 (pt) |
| JP (1) | JP2022536687A (pt) |
| KR (1) | KR20220019796A (pt) |
| CN (1) | CN114423427A (pt) |
| AR (1) | AR120055A1 (pt) |
| AU (1) | AU2020291002A1 (pt) |
| BR (1) | BR112021024886A2 (pt) |
| CA (1) | CA3141226A1 (pt) |
| CL (1) | CL2021003280A1 (pt) |
| EA (1) | EA202290024A1 (pt) |
| IL (1) | IL288677A (pt) |
| MX (1) | MX2021015352A (pt) |
| TW (1) | TW202112372A (pt) |
| WO (1) | WO2020252129A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007253900A1 (en) | 2006-05-16 | 2007-11-29 | Amicus Therapeutics, Inc. | Assays for diagnosing and evaluating treatment options for fabry disease |
| AU2009214648B2 (en) | 2008-02-12 | 2014-11-13 | Amicus Therapeutics, Inc. | Method to predict response to pharmacological chaperone treatment of diseases |
| AU2018277756A1 (en) | 2017-05-30 | 2020-01-23 | Amicus Therapeutics, Inc. | Methods of treating fabry patients having renal impairment |
| JP7555818B2 (ja) | 2018-02-06 | 2024-09-25 | アミカス セラピューティックス インコーポレイテッド | 妊娠患者におけるファブリー病の治療のためのミガラスタットの使用 |
| EP3895708A3 (en) | 2019-08-07 | 2022-01-19 | Amicus Therapeutics, Inc. | Methods of treating fabry disease in patients having a mutation in the gla gene |
| US11623916B2 (en) | 2020-12-16 | 2023-04-11 | Amicus Therapeutics, Inc. | Highly purified batches of pharmaceutical grade migalastat and methods of producing the same |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6274597B1 (en) | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
| US20100113517A1 (en) | 2007-03-30 | 2010-05-06 | Amicus Therapeutics, Inc. | Method for the treatment of fabry disease using pharmacological chaperones |
| EP2150254A4 (en) * | 2007-04-26 | 2010-11-10 | Amicus Therapeutics Inc | DOSAGES FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES WITH PHARMACOLOGICAL CHAPTERONES |
| AU2009214648B2 (en) | 2008-02-12 | 2014-11-13 | Amicus Therapeutics, Inc. | Method to predict response to pharmacological chaperone treatment of diseases |
| KR20140011367A (ko) * | 2011-03-11 | 2014-01-28 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 파브리 병을 치료하기 위한 투여 요법 |
| CA3031249A1 (en) * | 2016-07-19 | 2018-01-25 | Amicus Therapeutics, Inc. | Treatment of fabry disease in ert-naive and ert-experienced patients |
| MX2019008076A (es) * | 2017-01-05 | 2019-08-29 | Protalix Ltd | Regimen terapeutico para el tratamiento de fabry usando alfa-galactosidasa estabilizada. |
| AR111971A1 (es) * | 2017-05-30 | 2019-09-04 | Amicus Therapeutics Inc | Métodos para tratar pacientes con enfermedad de fabry que tienen insuficiencia renal |
| AU2018277756A1 (en) * | 2017-05-30 | 2020-01-23 | Amicus Therapeutics, Inc. | Methods of treating fabry patients having renal impairment |
-
2020
- 2020-06-11 EA EA202290024A patent/EA202290024A1/ru unknown
- 2020-06-11 BR BR112021024886A patent/BR112021024886A2/pt unknown
- 2020-06-11 CN CN202080042938.3A patent/CN114423427A/zh active Pending
- 2020-06-11 MX MX2021015352A patent/MX2021015352A/es unknown
- 2020-06-11 AR ARP200101648A patent/AR120055A1/es unknown
- 2020-06-11 WO PCT/US2020/037174 patent/WO2020252129A1/en unknown
- 2020-06-11 KR KR1020227000878A patent/KR20220019796A/ko unknown
- 2020-06-11 JP JP2021573404A patent/JP2022536687A/ja active Pending
- 2020-06-11 US US17/618,277 patent/US20220313670A1/en active Pending
- 2020-06-11 AU AU2020291002A patent/AU2020291002A1/en active Pending
- 2020-06-11 EP EP20751716.0A patent/EP3982962A1/en active Pending
- 2020-06-11 TW TW109119640A patent/TW202112372A/zh unknown
- 2020-06-11 CA CA3141226A patent/CA3141226A1/en active Pending
-
2021
- 2021-12-05 IL IL288677A patent/IL288677A/en unknown
- 2021-12-09 CL CL2021003280A patent/CL2021003280A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN114423427A (zh) | 2022-04-29 |
| IL288677A (en) | 2022-02-01 |
| CA3141226A1 (en) | 2020-12-17 |
| EP3982962A1 (en) | 2022-04-20 |
| KR20220019796A (ko) | 2022-02-17 |
| AU2020291002A1 (en) | 2022-01-06 |
| MX2021015352A (es) | 2022-04-06 |
| EA202290024A1 (ru) | 2022-03-14 |
| AR120055A1 (es) | 2022-02-02 |
| US20220313670A1 (en) | 2022-10-06 |
| TW202112372A (zh) | 2021-04-01 |
| JP2022536687A (ja) | 2022-08-18 |
| CL2021003280A1 (es) | 2022-10-07 |
| WO2020252129A1 (en) | 2020-12-17 |
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