BR112021023710A2 - Derivados de diazepinona como moduladores da montagem do capsídeo - Google Patents
Derivados de diazepinona como moduladores da montagem do capsídeoInfo
- Publication number
- BR112021023710A2 BR112021023710A2 BR112021023710A BR112021023710A BR112021023710A2 BR 112021023710 A2 BR112021023710 A2 BR 112021023710A2 BR 112021023710 A BR112021023710 A BR 112021023710A BR 112021023710 A BR112021023710 A BR 112021023710A BR 112021023710 A2 BR112021023710 A2 BR 112021023710A2
- Authority
- BR
- Brazil
- Prior art keywords
- modulators
- capsid assembly
- diazepinone derivatives
- diazepinone
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
derivados de diazepinona como moduladores da montagem do capsídeo. a presente invenção refere-se a compostos, composições e métodos para tratamento de doenças, síndromes, condições e distúrbios que são afetados por cam de hbv. tais compostos são representados pela fórmula (i) como se segue,em que r1, r2, r3, x e r4 são definidos no presente documento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962853533P | 2019-05-28 | 2019-05-28 | |
| PCT/EP2020/064750 WO2020239863A1 (en) | 2019-05-28 | 2020-05-27 | Diazepinone derivatives as capsid assembly modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021023710A2 true BR112021023710A2 (pt) | 2022-04-12 |
Family
ID=70968929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021023710A BR112021023710A2 (pt) | 2019-05-28 | 2020-05-27 | Derivados de diazepinona como moduladores da montagem do capsídeo |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220213102A1 (pt) |
| EP (1) | EP3976615A1 (pt) |
| JP (1) | JP2022534960A (pt) |
| KR (1) | KR20220015420A (pt) |
| CN (1) | CN113891889A (pt) |
| AU (1) | AU2020281804A1 (pt) |
| BR (1) | BR112021023710A2 (pt) |
| CA (1) | CA3136493A1 (pt) |
| MX (1) | MX2021014582A (pt) |
| WO (1) | WO2020239863A1 (pt) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114057739A (zh) * | 2016-06-29 | 2022-02-18 | 诺维拉治疗公司 | 二氮杂酮衍生物及其在治疗乙型肝炎感染中的用途 |
| JP6935434B2 (ja) * | 2016-06-29 | 2021-09-15 | ノヴィラ・セラピューティクス・インコーポレイテッド | オキサジアゼピノン誘導体及びｂ型肝炎感染症の治療におけるその使用 |
-
2020
- 2020-05-27 MX MX2021014582A patent/MX2021014582A/es unknown
- 2020-05-27 CN CN202080039616.3A patent/CN113891889A/zh active Pending
- 2020-05-27 AU AU2020281804A patent/AU2020281804A1/en not_active Abandoned
- 2020-05-27 EP EP20729988.4A patent/EP3976615A1/en not_active Withdrawn
- 2020-05-27 BR BR112021023710A patent/BR112021023710A2/pt not_active Application Discontinuation
- 2020-05-27 KR KR1020217042020A patent/KR20220015420A/ko unknown
- 2020-05-27 CA CA3136493A patent/CA3136493A1/en active Pending
- 2020-05-27 JP JP2021570714A patent/JP2022534960A/ja active Pending
- 2020-05-27 WO PCT/EP2020/064750 patent/WO2020239863A1/en unknown
- 2020-05-27 US US17/595,772 patent/US20220213102A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020239863A1 (en) | 2020-12-03 |
| US20220213102A1 (en) | 2022-07-07 |
| KR20220015420A (ko) | 2022-02-08 |
| MX2021014582A (es) | 2022-01-11 |
| CA3136493A1 (en) | 2020-05-27 |
| AU2020281804A1 (en) | 2021-11-25 |
| CN113891889A (zh) | 2022-01-04 |
| JP2022534960A (ja) | 2022-08-04 |
| EP3976615A1 (en) | 2022-04-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |