BR112021022879A2 - Sistemas e métodos para avaliação de fração tumoral - Google Patents
Sistemas e métodos para avaliação de fração tumoralInfo
- Publication number
- BR112021022879A2 BR112021022879A2 BR112021022879A BR112021022879A BR112021022879A2 BR 112021022879 A2 BR112021022879 A2 BR 112021022879A2 BR 112021022879 A BR112021022879 A BR 112021022879A BR 112021022879 A BR112021022879 A BR 112021022879A BR 112021022879 A2 BR112021022879 A2 BR 112021022879A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- tumor fraction
- systems
- sample
- metric
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/10—Ploidy or copy number detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medical Informatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Data Mining & Analysis (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Databases & Information Systems (AREA)
- Bioethics (AREA)
- Evolutionary Computation (AREA)
- Artificial Intelligence (AREA)
- Software Systems (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Primary Health Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962850474P | 2019-05-20 | 2019-05-20 | |
| PCT/US2020/033821 WO2020236941A1 (en) | 2019-05-20 | 2020-05-20 | Systems and methods for evaluating tumor fraction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021022879A2 true BR112021022879A2 (pt) | 2022-03-22 |
Family
ID=73458622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021022879A BR112021022879A2 (pt) | 2019-05-20 | 2020-05-20 | Sistemas e métodos para avaliação de fração tumoral |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20220243279A1 (https=) |
| EP (1) | EP3973530A4 (https=) |
| JP (1) | JP7702360B2 (https=) |
| KR (1) | KR20220011140A (https=) |
| CN (1) | CN114026646A (https=) |
| AU (2) | AU2020279752A1 (https=) |
| BR (1) | BR112021022879A2 (https=) |
| CA (1) | CA3140066A1 (https=) |
| IL (1) | IL288182A (https=) |
| SG (1) | SG11202111947PA (https=) |
| WO (1) | WO2020236941A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES3022582T3 (en) | 2013-05-10 | 2025-05-28 | Found Medicine Inc | Analysis of genetic variants |
| JP2023552391A (ja) * | 2020-12-03 | 2023-12-15 | ファウンデーション・メディシン・インコーポレイテッド | 治療を選択し、予想される治療転帰を判定するための木ベースのモデル |
| EP4266315A4 (en) * | 2020-12-16 | 2024-11-20 | Seedna Inc. | METHOD FOR CALCULATING THE RELIABILITY VALUE OF A POLYMORPHISM LOCUS SIGNAL |
| CN113025716A (zh) * | 2021-03-02 | 2021-06-25 | 北京大学第一医院 | 一种用于人肿瘤分级的基因组合及其用途 |
| WO2022271159A1 (en) * | 2021-06-22 | 2022-12-29 | Foundation Medicine, Inc. | Systems and methods for evaluating tumor fraction |
| EP4374376A4 (en) * | 2021-07-23 | 2025-05-28 | Foundation Medicine, Inc. | METHODS FOR DETERMINING VARIANT FREQUENCY AND MONITORING DISEASE PROGRESSION |
| JP2024538725A (ja) * | 2021-10-08 | 2024-10-23 | ファウンデーション・メディシン・インコーポレイテッド | コピー数変化呼び出しに対する汚染を検出及び除去するための方法及びシステム |
| EP4430614A4 (en) * | 2021-11-12 | 2025-12-17 | Found Medicine Inc | Circulating tumor DNA fraction and uses thereof |
| WO2023096658A1 (en) * | 2021-11-23 | 2023-06-01 | Foundation Medicine, Inc. | Methods and systems for reporting clinically-actionable potential germline pathogenic variant sequences |
| US20250037823A1 (en) | 2021-12-08 | 2025-01-30 | Foundation Medicine, Inc. | Methods and systems for highlighting clinical information in diagnostic reports |
| CN114530200B (zh) * | 2022-03-18 | 2022-09-23 | 北京阅微基因技术股份有限公司 | 基于计算snp熵值的混合样本鉴定方法 |
| CN119585730A (zh) * | 2022-07-15 | 2025-03-07 | 基金会医学公司 | 用于确定患者样品中循环肿瘤dna分数的方法和系统 |
| WO2024081859A2 (en) * | 2022-10-14 | 2024-04-18 | Foundation Medicine, Inc. | Methods and systems for performing genomic variant calls based on identified off-target sequence reads |
| WO2024112967A1 (en) * | 2022-11-27 | 2024-05-30 | The University Of Chicago | Methods for treating cancer with immunotherapy |
| EP4631049A4 (en) * | 2022-12-09 | 2026-02-18 | Found Medicine Inc | METHODS AND SYSTEMS FOR DETERMINING THE CLONALITY OF SOMATIC SHORT VARIANTS |
| CN121219428A (zh) * | 2023-05-15 | 2025-12-26 | 基金会医学公司 | 用于评定液体活检样品中循环肿瘤dna分数的方法和系统 |
| WO2024238750A2 (en) * | 2023-05-17 | 2024-11-21 | Foundation Medicine, Inc. | Clonal hematopoiesis burden as a biomarker for immune checkpoint inhibitor response |
| WO2025054202A1 (en) | 2023-09-05 | 2025-03-13 | Sana Biotechnology, Inc. | Method of screening a sample comprising a transgene with a unique barcode |
| WO2025151838A1 (en) | 2024-01-12 | 2025-07-17 | Sana Biotechnology, Inc. | Safety switches to control in vitro and in vivo proliferation of cell therapy products |
| CN121305088B (zh) * | 2025-12-09 | 2026-03-17 | 中国人民解放军空军军医大学 | 迁移学习驱动的颅内肿瘤影像数据全自动分割方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110301854A1 (en) * | 2010-06-08 | 2011-12-08 | Curry Bo U | Method of Determining Allele-Specific Copy Number of a SNP |
| WO2014014498A1 (en) * | 2012-07-20 | 2014-01-23 | Verinata Health, Inc. | Detecting and classifying copy number variation in a fetal genome |
| US11261494B2 (en) * | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| CA2945962C (en) * | 2014-04-21 | 2023-08-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| WO2015164432A1 (en) * | 2014-04-21 | 2015-10-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| HUE058263T2 (hu) * | 2015-02-10 | 2022-07-28 | Univ Hong Kong Chinese | Mutációk detektálása rákszûrési és magzatelemzési célból |
| BR112018005940A2 (pt) * | 2015-09-25 | 2018-12-11 | Contextual Genomics Inc | métodos de garantia da qualidade molecular para uso em sequenciamento |
| CN114959918A (zh) * | 2016-02-29 | 2022-08-30 | 基础医疗股份有限公司 | 用于评估肿瘤突变负荷的方法和系统 |
| CA3067419A1 (en) * | 2017-06-20 | 2018-12-27 | Illumina, Inc. | Methods and systems for decomposition and quantification of dna mixtures from multiple contributors of known or unknown genotypes |
| JP7760242B2 (ja) * | 2017-07-21 | 2025-10-27 | ジェネンテック， インコーポレイテッド | がんの治療法及び診断法 |
-
2020
- 2020-05-20 CN CN202080037877.1A patent/CN114026646A/zh active Pending
- 2020-05-20 US US17/612,966 patent/US20220243279A1/en active Pending
- 2020-05-20 SG SG11202111947PA patent/SG11202111947PA/en unknown
- 2020-05-20 KR KR1020217040903A patent/KR20220011140A/ko active Pending
- 2020-05-20 EP EP20810118.8A patent/EP3973530A4/en active Pending
- 2020-05-20 CA CA3140066A patent/CA3140066A1/en active Pending
- 2020-05-20 BR BR112021022879A patent/BR112021022879A2/pt unknown
- 2020-05-20 WO PCT/US2020/033821 patent/WO2020236941A1/en not_active Ceased
- 2020-05-20 JP JP2021568292A patent/JP7702360B2/ja active Active
- 2020-05-20 AU AU2020279752A patent/AU2020279752A1/en not_active Abandoned
-
2021
- 2021-11-17 IL IL288182A patent/IL288182A/en unknown
-
2025
- 2025-04-04 US US19/171,081 patent/US20250259709A1/en active Pending
- 2025-11-27 AU AU2025271452A patent/AU2025271452A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN114026646A (zh) | 2022-02-08 |
| JP7702360B2 (ja) | 2025-07-03 |
| EP3973530A1 (en) | 2022-03-30 |
| IL288182A (en) | 2022-01-01 |
| KR20220011140A (ko) | 2022-01-27 |
| US20220243279A1 (en) | 2022-08-04 |
| AU2025271452A1 (en) | 2026-01-29 |
| WO2020236941A1 (en) | 2020-11-26 |
| AU2020279752A1 (en) | 2022-01-06 |
| JP2022533137A (ja) | 2022-07-21 |
| CA3140066A1 (en) | 2020-11-26 |
| SG11202111947PA (en) | 2021-12-30 |
| US20250259709A1 (en) | 2025-08-14 |
| EP3973530A4 (en) | 2023-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |