BR112021022621A2 - Proteína mutante il-2 proliferando células imunes - Google Patents
Proteína mutante il-2 proliferando células imunesInfo
- Publication number
- BR112021022621A2 BR112021022621A2 BR112021022621A BR112021022621A BR112021022621A2 BR 112021022621 A2 BR112021022621 A2 BR 112021022621A2 BR 112021022621 A BR112021022621 A BR 112021022621A BR 112021022621 A BR112021022621 A BR 112021022621A BR 112021022621 A2 BR112021022621 A2 BR 112021022621A2
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- mutant
- immune cells
- affinity
- mutant protein
- Prior art date
Links
- 108010002350 Interleukin-2 Proteins 0.000 title abstract 7
- 102000008300 Mutant Proteins Human genes 0.000 title abstract 2
- 108010021466 Mutant Proteins Proteins 0.000 title abstract 2
- 210000002865 immune cell Anatomy 0.000 title abstract 2
- 230000002062 proliferating effect Effects 0.000 title abstract 2
- 102000000588 Interleukin-2 Human genes 0.000 abstract 6
- 102000010789 Interleukin-2 Receptors Human genes 0.000 abstract 2
- 108010038453 Interleukin-2 Receptors Proteins 0.000 abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
PROTEÍNA MUTANTE IL-2 PROLIFERANDO CÉLULAS IMUNES. São fornecidos na presente invenção uma proteína mutante de IL-2, uma proteína de fusão ou conjugado contendo a proteína mutante de IL-2 e uma composição farmacêutica contendo a proteína mutante de IL-2, proteína de fusão ou conjugado. Em comparação com a proteína IL-2 de tipo selvagem, a proteína mutante IL-2 da presente invenção elimina ou reduz a afinidade para um receptor de IL-2 de alta afinidade e retém substancialmente a afinidade para um receptor de IL-2 de afinidade média.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910399641.1A CN111944036A (zh) | 2019-05-14 | 2019-05-14 | 一种增殖免疫细胞的突变体蛋白 |
PCT/CN2020/090365 WO2020228791A1 (zh) | 2019-05-14 | 2020-05-14 | 增殖免疫细胞的il-2突变体蛋白 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021022621A2 true BR112021022621A2 (pt) | 2022-07-19 |
Family
ID=73289362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021022621A BR112021022621A2 (pt) | 2019-05-14 | 2020-05-14 | Proteína mutante il-2 proliferando células imunes |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220227829A1 (pt) |
EP (1) | EP3971205A4 (pt) |
JP (1) | JP2022533636A (pt) |
KR (1) | KR20220008323A (pt) |
CN (2) | CN111944036A (pt) |
AU (1) | AU2020274833A1 (pt) |
BR (1) | BR112021022621A2 (pt) |
CA (1) | CA3139833A1 (pt) |
SG (1) | SG11202112710VA (pt) |
WO (1) | WO2020228791A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4130027A1 (en) * | 2020-03-31 | 2023-02-08 | Hanmi Pharm. Co., Ltd. | Novel immunoactive interleukin 2 analog |
CN113667003A (zh) * | 2020-05-14 | 2021-11-19 | 上海盖浦生物科技有限公司 | 一种增殖调节性t细胞的突变体蛋白 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5229109A (en) | 1992-04-14 | 1993-07-20 | Board Of Regents, The University Of Texas System | Low toxicity interleukin-2 analogues for use in immunotherapy |
WO2003015697A2 (en) * | 2001-08-13 | 2003-02-27 | University Of Southern California | Interleukin-2 mutants with reduced toxicity |
BR0214650A (pt) * | 2001-12-04 | 2005-05-03 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
US7569215B2 (en) * | 2003-07-18 | 2009-08-04 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
NZ548612A (en) * | 2004-02-09 | 2009-11-27 | Human Genome Sciences Inc | Albumin fusion proteins comprising tandem GLP-1 |
CN1930300A (zh) * | 2004-03-05 | 2007-03-14 | 希龙公司 | 预测患者治疗药物耐受性的体外试验系统 |
AU2011218682B2 (en) * | 2005-05-11 | 2013-11-21 | Eth Zurich | Recombinant N-glycosylated proteins from procaryotic cells |
PT2066796E (pt) | 2006-09-20 | 2011-10-11 | Mt Biomethan Gmbh | Procedimento e dispositivo para a separação do metano e do dióxido de carbono do biogás |
US20110154516A1 (en) * | 2007-10-15 | 2011-06-23 | Stafford Darrel W | Human factor ix variants with an extended half life |
US8906356B2 (en) | 2007-11-05 | 2014-12-09 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
CN105440123B (zh) * | 2011-02-10 | 2020-10-09 | 罗切格利卡特公司 | 突变体白介素-2多肽 |
US9580486B2 (en) * | 2013-03-14 | 2017-02-28 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
JP2016519651A (ja) * | 2013-03-15 | 2016-07-07 | アンジェリカ セラピューティックス,インク. | 改質された毒素 |
CN104231068A (zh) * | 2014-01-27 | 2014-12-24 | 苏州发士达生物科技有限公司 | 人白细胞介素ii突变体及其应用 |
EP3102595B1 (en) * | 2014-02-06 | 2018-11-07 | F.Hoffmann-La Roche Ag | Interleukin-2 fusion proteins and uses thereof |
MA40721A (fr) | 2014-08-06 | 2017-06-13 | The Univ Of Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
CN116472281A (zh) * | 2020-04-28 | 2023-07-21 | 安维塔生物科学股份有限公司 | 白介素-2多肽及其融合蛋白,及其药物组合物和治疗应用 |
-
2019
- 2019-05-14 CN CN201910399641.1A patent/CN111944036A/zh active Pending
-
2020
- 2020-05-14 SG SG11202112710VA patent/SG11202112710VA/en unknown
- 2020-05-14 CA CA3139833A patent/CA3139833A1/en active Pending
- 2020-05-14 WO PCT/CN2020/090365 patent/WO2020228791A1/zh unknown
- 2020-05-14 EP EP20805955.0A patent/EP3971205A4/en active Pending
- 2020-05-14 JP JP2021568420A patent/JP2022533636A/ja active Pending
- 2020-05-14 US US17/610,538 patent/US20220227829A1/en active Pending
- 2020-05-14 BR BR112021022621A patent/BR112021022621A2/pt unknown
- 2020-05-14 KR KR1020217040863A patent/KR20220008323A/ko unknown
- 2020-05-14 CN CN202080035883.3A patent/CN113939528A/zh active Pending
- 2020-05-14 AU AU2020274833A patent/AU2020274833A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3139833A1 (en) | 2020-11-19 |
WO2020228791A1 (zh) | 2020-11-19 |
CN113939528A (zh) | 2022-01-14 |
EP3971205A4 (en) | 2023-09-06 |
EP3971205A1 (en) | 2022-03-23 |
US20220227829A1 (en) | 2022-07-21 |
CN111944036A (zh) | 2020-11-17 |
AU2020274833A1 (en) | 2022-01-06 |
SG11202112710VA (en) | 2021-12-30 |
JP2022533636A (ja) | 2022-07-25 |
KR20220008323A (ko) | 2022-01-20 |
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