BR112021013559A2 - Moléculas de ligação a receptor de transferrina, conjugados das mesmas e seus usos - Google Patents
Moléculas de ligação a receptor de transferrina, conjugados das mesmas e seus usos Download PDFInfo
- Publication number
- BR112021013559A2 BR112021013559A2 BR112021013559-6A BR112021013559A BR112021013559A2 BR 112021013559 A2 BR112021013559 A2 BR 112021013559A2 BR 112021013559 A BR112021013559 A BR 112021013559A BR 112021013559 A2 BR112021013559 A2 BR 112021013559A2
- Authority
- BR
- Brazil
- Prior art keywords
- vhh
- seq
- nos
- molecule
- tfr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2881—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19305031.7 | 2019-01-09 | ||
| EP19305031 | 2019-01-09 | ||
| PCT/EP2020/050318 WO2020144233A1 (en) | 2019-01-09 | 2020-01-08 | Transferrin receptor-binding molecules, conjugates thereof and their uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021013559A2 true BR112021013559A2 (pt) | 2021-09-21 |
Family
ID=65236972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021013559-6A BR112021013559A2 (pt) | 2019-01-09 | 2020-01-08 | Moléculas de ligação a receptor de transferrina, conjugados das mesmas e seus usos |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12152317B2 (https=) |
| EP (1) | EP3908608A1 (https=) |
| JP (1) | JP7599425B2 (https=) |
| CN (1) | CN113474369B (https=) |
| AU (1) | AU2020206593B2 (https=) |
| BR (1) | BR112021013559A2 (https=) |
| CA (1) | CA3124790A1 (https=) |
| EA (1) | EA202191893A1 (https=) |
| WO (1) | WO2020144233A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12258597B2 (en) | 2018-02-07 | 2025-03-25 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for therapeutic protein delivery |
| US20240391967A1 (en) * | 2020-12-02 | 2024-11-28 | University Health Network | Methods and uses for ndfip1 fusion polypeptides in treating neurodegenerative diseases, brain and/or traumatic and non-traumatic spinal cord injuries, and/or optic neuropathies |
| MX2024005968A (es) * | 2021-11-19 | 2024-08-06 | Japan Chem Res | Peptido que tiene afinidad por el receptor de transferrina humano. |
| CN117377487B (zh) | 2021-12-02 | 2024-11-22 | 领诺(上海)医药科技有限公司 | 转铁蛋白结合抗体及其应用 |
| US11939391B2 (en) * | 2021-12-06 | 2024-03-26 | MedAbome, Inc. | Anti-TfR1 antibody MAb11-22.1 conjugates for cancer treatment |
| WO2023128702A1 (ko) * | 2021-12-31 | 2023-07-06 | 주식회사 아임뉴런 | 뇌혈관장벽 투과성 융합 단백질 및 이의 용도 |
| CN119301262A (zh) | 2022-04-01 | 2025-01-10 | 武田药品工业株式会社 | 用于具有cns表现的疾病的基因疗法 |
| EP4526344A1 (en) * | 2022-05-16 | 2025-03-26 | Denali Therapeutics Inc. | Transferrin receptor-binding domains and proteins comprising the same |
| CN120659627A (zh) * | 2022-07-29 | 2025-09-16 | 瑞泽恩制药公司 | 用于转铁蛋白受体（tfr）介导的脑和肌肉递送的组合物和方法 |
| KR20250111123A (ko) | 2022-11-23 | 2025-07-22 | 키2브레인 에이비 | Vhh 항체 및 이의 용도 |
| US20260116990A1 (en) | 2022-11-23 | 2026-04-30 | Key2Brain Ab | Vhh antibodies and uses thereof |
| AU2023404617A1 (en) * | 2022-12-02 | 2025-05-29 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-tfr1 antibodies and uses thereof |
| TW202436352A (zh) * | 2023-02-07 | 2024-09-16 | 日商Ｊｃｒ製藥股份有限公司 | 人類運鐵蛋白受體親和性肽 |
| CN116179607A (zh) * | 2023-03-27 | 2023-05-30 | 迦进生物医药(上海)有限公司 | 一种human TfR2高表达的稳转细胞株及其构建方法和应用 |
| CN116121306A (zh) * | 2023-03-27 | 2023-05-16 | 迦进生物医药(上海)有限公司 | 一种human TfR1高表达的稳转细胞株及其构建方法和应用 |
| AU2024243709A1 (en) | 2023-04-03 | 2025-11-06 | Katholieke Universiteit Leuven | Blood-brain barrier crossing antibodies |
| CN121794291A (zh) | 2023-06-22 | 2026-04-03 | 维克塔-霍洛斯公司 | 转铁蛋白受体结合分子、其偶联物及其用于预防或治疗肌肉疾病的用途 |
| EP4731658A1 (en) | 2023-06-22 | 2026-04-29 | Vect-Horus | Transferrin receptor-binding molecules, conjugates thereof and their uses to prevent or treat nervous system diseases |
| EP4480964A1 (en) | 2023-06-22 | 2024-12-25 | Vect-Horus | Transferrin receptor-binding molecules, conjugates thereof and their uses to prevent or treat muscular diseases |
| EP4480965A1 (en) | 2023-06-22 | 2024-12-25 | Vect-Horus | Transferrin receptor-binding molecules, conjugates thereof and their uses to prevent or treat cns diseases |
| CN121773136A (zh) * | 2023-07-04 | 2026-03-31 | 北京星奇原生物科技有限公司 | 抗-TfR1抗体及其用途 |
| WO2025042711A1 (en) | 2023-08-18 | 2025-02-27 | Eli Lilly And Company | Engineered transferrin receptor binding peptides as well as methods of making and using the same |
| US20250064958A1 (en) * | 2023-08-22 | 2025-02-27 | Eli Lilly And Company | AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENTS |
| WO2025194170A1 (en) * | 2024-03-15 | 2025-09-18 | Dana-Farber Cancer Institute, Inc. | Receptor-mediated endocytosis for targeted internalization and degradation of immune-related membrane proteins |
| WO2025194171A1 (en) * | 2024-03-15 | 2025-09-18 | Dana-Farber Cancer Institute, Inc. | Receptor-mediated endocytosis for targeted internalization and degradation of g protein-coupled receptors |
| WO2025207959A1 (en) * | 2024-03-27 | 2025-10-02 | Biogen Ma Inc. | Anti-transferrin receptor antibodies and uses thereof |
| WO2025207946A1 (en) * | 2024-03-28 | 2025-10-02 | Genzyme Corporation | Polypeptides binding to a specific epitope of the transferrin receptor 1 |
| WO2025226642A1 (en) | 2024-04-25 | 2025-10-30 | Eli Lilly And Company | Lipid nano delivery particles for targeted transport of nucleic acids and methods of making and using the same |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2441903C (en) * | 2000-05-26 | 2012-07-31 | National Research Council Of Canada | Single-domain brain-targeting antibody fragments derived from llama antibodies |
| EP2008666A1 (en) * | 2007-06-29 | 2008-12-31 | Institut Pasteur | Use of VHH antibodies for the preparation of peptide vectors for delivering a substance of interest and their applications |
| EP2207568B1 (en) | 2007-11-16 | 2017-05-31 | The Rockefeller University | Antibodies specific for the protofibril form of beta-amyloid protein |
| FR2937322B1 (fr) | 2008-10-22 | 2013-02-22 | Vect Horus | Derives peptidiques et leur utilisation comme vecteurs de molecules sous forme de conjugues |
| FR2959229B1 (fr) | 2010-04-21 | 2013-01-18 | Vect Horus | Derives peptidiques, leur preparation et leurs utilisations |
| CA2813411C (en) * | 2010-11-05 | 2016-08-02 | Rinat Neuroscience Corporation | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| CA2818173C (en) | 2010-11-30 | 2022-05-03 | Genentech, Inc. | Low affinity blood brain barrier receptor antibodies and uses therefor |
| WO2013177062A2 (en) | 2012-05-21 | 2013-11-28 | Genentech, Inc. | Methods for improving safety of blood-brain barrier transport |
| WO2014089209A2 (en) * | 2012-12-04 | 2014-06-12 | Abbvie, Inc. | Blood-brain barrier (bbb) penetrating dual specific binding proteins |
| CN105102478A (zh) * | 2013-01-30 | 2015-11-25 | 弗拉芒区生物技术研究所 | 用于筛选和药物发现目的的新型嵌合多肽 |
| EP2899208A1 (en) * | 2014-01-28 | 2015-07-29 | F.Hoffmann-La Roche Ag | Camelid single-domain antibody directed against phosphorylated tau proteins and methods for producing conjugates thereof |
| NZ724869A (en) * | 2014-03-06 | 2022-07-01 | Nat Res Council Canada | Insulin-like growth factor 1 receptor -specific antibodies and uses thereof |
| EP3218411B1 (en) | 2014-11-14 | 2022-01-12 | Ossianix, Inc. | Variable new antigen receptors (vnars) directed against transferrin receptor (tfr) and their use |
| EA039366B1 (ru) | 2015-06-24 | 2022-01-19 | Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД. | Антитело к рецептору трансферрина человека, проникающее через гематоэнцефалический барьер |
| EP3494216B1 (en) | 2016-08-06 | 2025-10-15 | Ossianix, Inc. | In vivo methods for selecting peptides that cross the blood brain barrier, related compositions and methods of use |
-
2020
- 2020-01-08 CA CA3124790A patent/CA3124790A1/en active Pending
- 2020-01-08 AU AU2020206593A patent/AU2020206593B2/en active Active
- 2020-01-08 US US17/421,412 patent/US12152317B2/en active Active
- 2020-01-08 EP EP20700450.8A patent/EP3908608A1/en active Pending
- 2020-01-08 EA EA202191893A patent/EA202191893A1/ru unknown
- 2020-01-08 JP JP2021540103A patent/JP7599425B2/ja active Active
- 2020-01-08 CN CN202080008202.4A patent/CN113474369B/zh active Active
- 2020-01-08 BR BR112021013559-6A patent/BR112021013559A2/pt unknown
- 2020-01-08 WO PCT/EP2020/050318 patent/WO2020144233A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020144233A1 (en) | 2020-07-16 |
| CN113474369A (zh) | 2021-10-01 |
| EP3908608A1 (en) | 2021-11-17 |
| JP7599425B2 (ja) | 2024-12-13 |
| JP2022518392A (ja) | 2022-03-15 |
| US12152317B2 (en) | 2024-11-26 |
| US20220090050A1 (en) | 2022-03-24 |
| CN113474369B (zh) | 2024-09-03 |
| EA202191893A1 (ru) | 2021-12-02 |
| CA3124790A1 (en) | 2020-07-16 |
| AU2020206593B2 (en) | 2026-02-05 |
| AU2020206593A1 (en) | 2021-07-15 |
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