BR112021009856A8 - Terapia para tratamento do câncer com uma administração intratumoral e / ou intravenosa de um mva recombinante que codifica 4-1bbl (cd137l) e / ou cd40l - Google Patents

Terapia para tratamento do câncer com uma administração intratumoral e / ou intravenosa de um mva recombinante que codifica 4-1bbl (cd137l) e / ou cd40l

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Publication number
BR112021009856A8
BR112021009856A8 BR112021009856A BR112021009856A BR112021009856A8 BR 112021009856 A8 BR112021009856 A8 BR 112021009856A8 BR 112021009856 A BR112021009856 A BR 112021009856A BR 112021009856 A BR112021009856 A BR 112021009856A BR 112021009856 A8 BR112021009856 A8 BR 112021009856A8
Authority
BR
Brazil
Prior art keywords
1bbl
cd40l
intratumoral
recombinant mva
cd137l
Prior art date
Application number
BR112021009856A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112021009856A2 (pt
Inventor
Henning Lauterbach
Medina Echeverz Jose
Maria Hinterberger
Original Assignee
Bavarian Nordic As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bavarian Nordic As filed Critical Bavarian Nordic As
Publication of BR112021009856A2 publication Critical patent/BR112021009856A2/pt
Publication of BR112021009856A8 publication Critical patent/BR112021009856A8/pt

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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4224—Molecules with a "CD" designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2740/10011—Retroviridae
    • C12N2740/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Communicable Diseases (AREA)
  • Hematology (AREA)
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BR112021009856A 2018-11-20 2019-11-20 Terapia para tratamento do câncer com uma administração intratumoral e / ou intravenosa de um mva recombinante que codifica 4-1bbl (cd137l) e / ou cd40l BR112021009856A8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP18207238 2018-11-20
EP18207238.9 2018-11-20
US201962807720P 2019-02-19 2019-02-19
US62/807,720 2019-02-19
PCT/EP2019/081942 WO2020104531A1 (en) 2018-11-20 2019-11-20 Therapy for treating cancer with an intratumoral and/or intravenous administration of a recombinant mva encoding 4-1bbl (cd137l) and/or cd40l

Publications (2)

Publication Number Publication Date
BR112021009856A2 BR112021009856A2 (pt) 2021-08-17
BR112021009856A8 true BR112021009856A8 (pt) 2021-09-08

Family

ID=68542659

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021009856A BR112021009856A8 (pt) 2018-11-20 2019-11-20 Terapia para tratamento do câncer com uma administração intratumoral e / ou intravenosa de um mva recombinante que codifica 4-1bbl (cd137l) e / ou cd40l

Country Status (12)

Country Link
US (1) US12390515B2 (https=)
EP (1) EP3883599A1 (https=)
JP (1) JP7625518B2 (https=)
KR (1) KR20210094535A (https=)
CN (1) CN113056284A (https=)
AU (1) AU2019385665B2 (https=)
BR (1) BR112021009856A8 (https=)
CA (1) CA3119503A1 (https=)
IL (1) IL283187A (https=)
MX (1) MX2021005560A (https=)
SG (1) SG11202104918PA (https=)
WO (1) WO2020104531A1 (https=)

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CN111050790B (zh) * 2017-08-24 2024-07-12 巴法里安诺迪克有限公司 通过静脉内施用重组mva和抗体治疗癌症的组合疗法
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
CR20220220A (es) 2019-11-18 2022-09-20 Janssen Biotech Inc Vacunas basadas en calr y jak2 mutantes y sus usos
US20230190922A1 (en) * 2019-11-20 2023-06-22 Bavarian Nordic A/S Recombinant MVA Viruses for Intratumoral and/or Intravenous Administration for Treating Cancer
IL293012A (en) * 2019-11-20 2022-07-01 Bavarian Nordic As Medicinal uses of 4-1bbl modified ankara virus vaccinia ((recombinant mva
US20230174653A1 (en) * 2020-04-06 2023-06-08 St. Jude Children's Research Hospital, Inc. B7-h3 chimeric antigen receptors
EP4175664A2 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Prostate neoantigens and their uses
WO2022036495A1 (en) 2020-08-17 2022-02-24 Utc Therapeutics Inc. Lymphocytes-antigen presenting cells co-stimulators and uses thereof
WO2023076768A1 (en) * 2021-10-26 2023-05-04 Navicure Biopharmaceuticals Limited Combination therapies against cancer and infectious diseases
WO2023118508A1 (en) * 2021-12-23 2023-06-29 Bavarian Nordic A/S Recombinant mva viruses for intraperitoneal administration for treating cancer
EP4452306A1 (en) 2021-12-23 2024-10-30 Bavarian Nordic A/S Therapy for modulating immune response with recombinant mva encoding il-12
CN117004579B (zh) * 2023-06-29 2024-11-15 苏州恩立维生物科技有限公司 重组溶瘤牛痘病毒及其应用

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US20220000997A1 (en) 2022-01-06
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KR20210094535A (ko) 2021-07-29
BR112021009856A2 (pt) 2021-08-17
CA3119503A1 (en) 2020-05-28
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