BR112020022612A2 - métodos e composições de terapia genética usando células reguláveis auxotróficas - Google Patents
métodos e composições de terapia genética usando células reguláveis auxotróficas Download PDFInfo
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| PCT/US2019/031699 WO2019217803A1 (en) | 2018-05-10 | 2019-05-10 | Gene therapy methods and compositions using auxotrophic regulatable cells |
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| US20230265440A1 (en) * | 2020-06-26 | 2023-08-24 | The Board Of Trustees Of The Leland Stanford Junior University | Targeting the human ccr5 locus as a safe harbor for the expression of therapeutic proteins |
| WO2025080701A1 (en) * | 2023-10-11 | 2025-04-17 | William Marsh Rice University | Genetically activated mesenchymal stem cells and stromal cells |
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| US20030232430A1 (en) | 2001-11-26 | 2003-12-18 | Advanced Cell Technology | Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells |
| CA2608913A1 (en) * | 2005-05-18 | 2006-11-23 | Biofactura, Inc. | Compositions and methods for metabolic selection of transfected cells |
| US20090176260A1 (en) | 2007-12-04 | 2009-07-09 | Joseph Ching-Ming Wu | Double-fusion human embryonic stem cells, methods of making double-fusion human embryonic stem cells, triple-fusion human embryonic stem cells, methods of making triple-fusion human embryonic stem cells, and methods of monitoring double-fusion human embryonic stem cells and triple-fusion human embryonic stem cells |
| EP3241902B1 (en) | 2012-05-25 | 2018-02-28 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| EP3363902B1 (en) | 2012-12-06 | 2019-11-27 | Sigma Aldrich Co. LLC | Crispr-based genome modification and regulation |
| CA2894684A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of improved crispr-cas systems, methods and enzyme compositions for sequence manipulation in eukaryotes |
| US20160122774A1 (en) | 2013-05-29 | 2016-05-05 | Cellectis | A method for producing precise dna cleavage using cas9 nickase activity |
| US11319555B2 (en) * | 2014-11-20 | 2022-05-03 | Duke University | Compositions, systems and methods for cell therapy |
| GB201618414D0 (en) * | 2016-11-01 | 2016-12-14 | Patterson James | Regulated cell lines and methods of use thereof |
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