BR112019008065A2 - composição para reduzir gordura, preparação para remover deposição de gordura localizada, kits, métodos para preparar uma composição, para remover deposição de gordura localizada e para a remoção não cirúrgica de deposição de gordura localizada - Google Patents
composição para reduzir gordura, preparação para remover deposição de gordura localizada, kits, métodos para preparar uma composição, para remover deposição de gordura localizada e para a remoção não cirúrgica de deposição de gordura localizadaInfo
- Publication number
- BR112019008065A2 BR112019008065A2 BR112019008065A BR112019008065A BR112019008065A2 BR 112019008065 A2 BR112019008065 A2 BR 112019008065A2 BR 112019008065 A BR112019008065 A BR 112019008065A BR 112019008065 A BR112019008065 A BR 112019008065A BR 112019008065 A2 BR112019008065 A2 BR 112019008065A2
- Authority
- BR
- Brazil
- Prior art keywords
- localized fat
- fat deposition
- composition
- preparing
- deposition
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000008021 deposition Effects 0.000 title 3
- 238000001356 surgical procedure Methods 0.000 title 1
- 206010030113 Oedema Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000036407 pain Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010002091 Anaesthesia Diseases 0.000 abstract 1
- 206010006784 Burning sensation Diseases 0.000 abstract 1
- 208000019505 Deglutition disease Diseases 0.000 abstract 1
- 206010015150 Erythema Diseases 0.000 abstract 1
- 108010007979 Glycocholic Acid Proteins 0.000 abstract 1
- 206010060708 Induration Diseases 0.000 abstract 1
- RFDAIACWWDREDC-UHFFFAOYSA-N Na salt-Glycocholic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCC(O)=O)C)C1(C)C(O)C2 RFDAIACWWDREDC-UHFFFAOYSA-N 0.000 abstract 1
- 208000028389 Nerve injury Diseases 0.000 abstract 1
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 206010042674 Swelling Diseases 0.000 abstract 1
- WBWWGRHZICKQGZ-UHFFFAOYSA-N Taurocholic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCCS(O)(=O)=O)C)C1(C)C(O)C2 WBWWGRHZICKQGZ-UHFFFAOYSA-N 0.000 abstract 1
- 210000001789 adipocyte Anatomy 0.000 abstract 1
- 230000037005 anaesthesia Effects 0.000 abstract 1
- 231100000321 erythema Toxicity 0.000 abstract 1
- 210000002950 fibroblast Anatomy 0.000 abstract 1
- RFDAIACWWDREDC-FRVQLJSFSA-N glycocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 RFDAIACWWDREDC-FRVQLJSFSA-N 0.000 abstract 1
- 229940099347 glycocholic acid Drugs 0.000 abstract 1
- 210000000663 muscle cell Anatomy 0.000 abstract 1
- 230000017074 necrotic cell death Effects 0.000 abstract 1
- 230000008764 nerve damage Effects 0.000 abstract 1
- 208000035824 paresthesia Diseases 0.000 abstract 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- WBWWGRHZICKQGZ-GIHLXUJPSA-N taurocholic acid Chemical compound C([C@@H]1C[C@H]2O)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@H](O)C1 WBWWGRHZICKQGZ-GIHLXUJPSA-N 0.000 abstract 1
- 210000003556 vascular endothelial cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
Abstract
a presente invenção refere-se a uma composição para reduzir a gordura localizada sem dor, edema e efeito secundário, e um método para preparar a mesma. mais especificamente, a presente invenção refere-se a uma composição compreendendo ácido glicocólico (ou um sal do mesmo) ou ácido taurocólico (ou um sal do mesmo) e fosfatidilcolina (ppc) em uma razão de mistura particular para reduzir a gordura localizada sem efeitos secundários tais como dor, edema, necrose de células musculares, fibroblastos e células endoteliais vasculares, a não ser adipócitos, anestesia de locais de administração, inchaço extenso, eritema, enduração, parestesia, nódulo, prurido, sensação de queimadura, lesão de nervo e disfagia, e um método para preparar a mesmo.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2017-0051868 | 2017-04-21 | ||
| KR20170051868 | 2017-04-21 | ||
| KR20170146264 | 2017-11-03 | ||
| KR10-2017-0146264 | 2017-11-03 | ||
| PCT/KR2018/004642 WO2018194427A1 (ko) | 2017-04-21 | 2018-04-20 | 통증과 부종 그리고 부작용이 없는 국소지방 감소용 주사제 조성물 및 이의 제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112019008065A2 true BR112019008065A2 (pt) | 2019-07-02 |
| BR112019008065B1 BR112019008065B1 (pt) | 2024-08-20 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| CO2019004317A2 (es) | 2019-05-10 |
| EP3479827A4 (en) | 2019-08-07 |
| CA3031678C (en) | 2021-08-31 |
| CN109862897B (zh) | 2024-01-30 |
| MX2019002289A (es) | 2019-09-26 |
| AU2018256263A1 (en) | 2019-05-16 |
| JP2020517581A (ja) | 2020-06-18 |
| ES2949946T3 (es) | 2023-10-04 |
| IL266873B1 (en) | 2023-12-01 |
| KR101887586B1 (ko) | 2018-08-10 |
| WO2018194427A8 (ko) | 2019-01-03 |
| CN109862897A (zh) | 2019-06-07 |
| US20190201328A1 (en) | 2019-07-04 |
| US11298314B2 (en) | 2022-04-12 |
| JP7034497B2 (ja) | 2022-03-14 |
| IL266873B2 (en) | 2024-04-01 |
| RU2736974C1 (ru) | 2020-11-23 |
| CA3031678A1 (en) | 2018-10-25 |
| WO2018194427A1 (ko) | 2018-10-25 |
| AU2018256263B2 (en) | 2021-05-06 |
| EP3479827B1 (en) | 2023-05-10 |
| IL266873A (en) | 2019-08-29 |
| EP3479827A1 (en) | 2019-05-08 |
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Legal Events
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/04/2018, OBSERVADAS AS CONDICOES LEGAIS |