BR112019004749A2 - identificação e isolamento do progenitor ótico humano - Google Patents
identificação e isolamento do progenitor ótico humanoInfo
- Publication number
- BR112019004749A2 BR112019004749A2 BR112019004749A BR112019004749A BR112019004749A2 BR 112019004749 A2 BR112019004749 A2 BR 112019004749A2 BR 112019004749 A BR112019004749 A BR 112019004749A BR 112019004749 A BR112019004749 A BR 112019004749A BR 112019004749 A2 BR112019004749 A2 BR 112019004749A2
- Authority
- BR
- Brazil
- Prior art keywords
- identification
- human optical
- progenitor
- isolation
- progenitor cells
- Prior art date
Links
- 230000003287 optical effect Effects 0.000 title abstract 5
- 238000002955 isolation Methods 0.000 title abstract 2
- 210000000130 stem cell Anatomy 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 abstract 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 abstract 1
- CXQCLLQQYTUUKJ-ALWAHNIESA-N beta-D-GalpNAc-(1->4)-[alpha-Neup5Ac-(2->8)-alpha-Neup5Ac-(2->3)]-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer(d18:1/18:0) Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@H](NC(=O)CCCCCCCCCCCCCCCCC)[C@H](O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@@H](CO)O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 CXQCLLQQYTUUKJ-ALWAHNIESA-N 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- LGRBZCLULGFXOD-DQMMGUQESA-L disodium (2S,4S,5R,6R)-5-acetamido-6-[(1S,2R)-2-[(2S,4S,5R,6R)-5-acetamido-2-carboxylato-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxan-2-yl]oxy-1,3-dihydroxypropyl]-2-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E,2S,3R)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxyoxane-2-carboxylate Chemical compound [Na+].[Na+].CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O[C@@]3(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O3)[C@H](O)[C@@H](CO)O[C@@]3(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O3)[C@H](O)[C@H](O)CO)C([O-])=O)C([O-])=O)[C@H]2O)[C@H](O)[C@H]1O)[C@H](O)\C=C\CCCCCCCCCCCCC LGRBZCLULGFXOD-DQMMGUQESA-L 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/7452—Thrombomodulin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Developmental Biology & Embryology (AREA)
- Neurology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Plant Substances (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
Abstract
a presente invenção se refere de forma geral à identificação e isolamento de células progenitoras óticas humanas. mais especificamente, a presente invenção se refere a um método de utilização de marcadores celulares para identificar e isolar células progenitoras óticas humanas de uma população mista de células, métodos de enriquecimento e produção de células progenitoras óticas humanas e kits associados para utilização na identificação e/ou isolamento de células progenitoras óticas humanas, em que os marcadores celulares são selecionados de ssea1 (cd15), disialogangliosídeo gd3, tra-2-49 (fosfatase alcalina de fígado/osso/rim), ssea4, gangliosídeo gd2 e cd141.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1615714.1A GB201615714D0 (en) | 2016-09-15 | 2016-09-15 | Otic progenitor identification and isolation |
| PCT/GB2017/052707 WO2018051092A1 (en) | 2016-09-15 | 2017-09-14 | Human otic progenitor identification and isolation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019004749A2 true BR112019004749A2 (pt) | 2019-05-28 |
Family
ID=57288819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019004749A BR112019004749A2 (pt) | 2016-09-15 | 2017-09-14 | identificação e isolamento do progenitor ótico humano |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US11634687B2 (pt) |
| EP (1) | EP3513191B1 (pt) |
| JP (1) | JP7134488B2 (pt) |
| KR (1) | KR102409178B1 (pt) |
| CN (1) | CN109716133B (pt) |
| AU (1) | AU2017328903B2 (pt) |
| BR (1) | BR112019004749A2 (pt) |
| CA (1) | CA3034529A1 (pt) |
| CL (1) | CL2019000682A1 (pt) |
| CO (1) | CO2019002095A2 (pt) |
| CY (1) | CY1124285T1 (pt) |
| DK (1) | DK3513191T3 (pt) |
| ES (1) | ES2877795T3 (pt) |
| GB (1) | GB201615714D0 (pt) |
| HR (1) | HRP20211049T1 (pt) |
| HU (1) | HUE055453T2 (pt) |
| IL (1) | IL265288B2 (pt) |
| LT (1) | LT3513191T (pt) |
| MA (1) | MA46424B1 (pt) |
| MX (1) | MX2019002995A (pt) |
| PL (1) | PL3513191T3 (pt) |
| PT (1) | PT3513191T (pt) |
| RS (1) | RS62083B1 (pt) |
| RU (1) | RU2768720C2 (pt) |
| SG (1) | SG11201901410SA (pt) |
| SI (1) | SI3513191T1 (pt) |
| WO (1) | WO2018051092A1 (pt) |
| ZA (1) | ZA201902342B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201615714D0 (en) * | 2016-09-15 | 2016-11-02 | Univ Of Sheffield The | Otic progenitor identification and isolation |
| GB202213060D0 (en) | 2022-09-07 | 2022-10-19 | Rinri Therapeutics Ltd | Surgical method for treatment of auditory disease or condition |
| GB202214291D0 (en) | 2022-09-29 | 2022-11-16 | Rinri Therapeutics Ltd | Laminin culture protocol |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2379683A1 (en) | 1999-07-20 | 2001-01-25 | University Of Southern California | Identification of pluripotent pre-mesenchymal, pre-hematopoietic progenitor cell |
| US6436704B1 (en) | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
| US6534052B1 (en) | 2000-09-05 | 2003-03-18 | Yong-Fu Xiao | Cardiac function comprising implantation of embryonic stem cell in which differentiation has been initiated |
| DE60230774D1 (de) | 2001-04-20 | 2009-02-26 | Children S Hospital Of Orange | Isolierung von nervenstammzellen unter verwendung von gangliosiden und anderen oberflächenmarkern |
| US8673634B2 (en) | 2003-11-13 | 2014-03-18 | Massachusetts Eye & Ear Infirmary | Method for the treatment of hearing loss |
| WO2007117573A2 (en) | 2006-04-07 | 2007-10-18 | Cold Spring Harbor Laboratory | Transgenic mice for identifying and assessing neural stem/ progenitor cells |
| WO2008132722A1 (en) * | 2007-04-26 | 2008-11-06 | Ramot At Tel-Aviv University Ltd. | Pluripotent autologous stem cells from oral mucosa and methods of use |
| GB2450747A (en) | 2007-07-06 | 2009-01-07 | Univ Sheffield | Treatment of sensorineural hearing loss |
| RU2525223C2 (ru) * | 2009-06-08 | 2014-08-10 | Иалоджик Кореа Инк. | Способ стимулирования области волосковых сенсорных клеток |
| EP2667881A4 (en) * | 2011-01-24 | 2015-04-22 | Univ Leland Stanford Junior | METHODS OF GENERATING IN VITRO INTERNAL EAR CELLS |
| CA2864818C (en) * | 2012-02-17 | 2022-05-03 | The Schepens Eye Research Institute | Phenotype profile of human retinal progenitor cells |
| WO2013188679A1 (en) | 2012-06-13 | 2013-12-19 | Stemgent, Inc. | Methods of preparing pluripotent stem cells |
| GB201615714D0 (en) * | 2016-09-15 | 2016-11-02 | Univ Of Sheffield The | Otic progenitor identification and isolation |
-
2016
- 2016-09-15 GB GBGB1615714.1A patent/GB201615714D0/en not_active Ceased
-
2017
- 2017-09-14 SI SI201730828T patent/SI3513191T1/sl unknown
- 2017-09-14 MA MA46424A patent/MA46424B1/fr unknown
- 2017-09-14 AU AU2017328903A patent/AU2017328903B2/en active Active
- 2017-09-14 MX MX2019002995A patent/MX2019002995A/es unknown
- 2017-09-14 CN CN201780056911.8A patent/CN109716133B/zh active Active
- 2017-09-14 JP JP2019511989A patent/JP7134488B2/ja active Active
- 2017-09-14 PT PT177715364T patent/PT3513191T/pt unknown
- 2017-09-14 SG SG11201901410SA patent/SG11201901410SA/en unknown
- 2017-09-14 KR KR1020197007122A patent/KR102409178B1/ko active IP Right Grant
- 2017-09-14 US US16/329,935 patent/US11634687B2/en active Active
- 2017-09-14 HU HUE17771536A patent/HUE055453T2/hu unknown
- 2017-09-14 PL PL17771536T patent/PL3513191T3/pl unknown
- 2017-09-14 BR BR112019004749A patent/BR112019004749A2/pt unknown
- 2017-09-14 WO PCT/GB2017/052707 patent/WO2018051092A1/en unknown
- 2017-09-14 RS RS20210826A patent/RS62083B1/sr unknown
- 2017-09-14 LT LTEP17771536.4T patent/LT3513191T/lt unknown
- 2017-09-14 ES ES17771536T patent/ES2877795T3/es active Active
- 2017-09-14 DK DK17771536.4T patent/DK3513191T3/da active
- 2017-09-14 CA CA3034529A patent/CA3034529A1/en active Pending
- 2017-09-14 RU RU2019110990A patent/RU2768720C2/ru active
- 2017-09-14 IL IL265288A patent/IL265288B2/en unknown
- 2017-09-14 EP EP17771536.4A patent/EP3513191B1/en active Active
-
2019
- 2019-03-05 CO CONC2019/0002095A patent/CO2019002095A2/es unknown
- 2019-03-15 CL CL2019000682A patent/CL2019000682A1/es unknown
- 2019-04-12 ZA ZA2019/02342A patent/ZA201902342B/en unknown
-
2021
- 2021-06-30 HR HRP20211049TT patent/HRP20211049T1/hr unknown
- 2021-06-30 CY CY20211100581T patent/CY1124285T1/el unknown
-
2023
- 2023-03-13 US US18/182,829 patent/US20230313134A1/en active Pending
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |