CL2019000682A1 - Identificación y aislamiento del progenitor ótico humano. - Google Patents

Identificación y aislamiento del progenitor ótico humano.

Info

Publication number
CL2019000682A1
CL2019000682A1 CL2019000682A CL2019000682A CL2019000682A1 CL 2019000682 A1 CL2019000682 A1 CL 2019000682A1 CL 2019000682 A CL2019000682 A CL 2019000682A CL 2019000682 A CL2019000682 A CL 2019000682A CL 2019000682 A1 CL2019000682 A1 CL 2019000682A1
Authority
CL
Chile
Prior art keywords
isolation
identification
cells
production
human
Prior art date
Application number
CL2019000682A
Other languages
English (en)
Inventor
Carlos Marcelo Nicolas Rivolta
Sarah Louise Boddy
Original Assignee
Univ Sheffield
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Sheffield filed Critical Univ Sheffield
Publication of CL2019000682A1 publication Critical patent/CL2019000682A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/7452—Thrombomodulin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE DE MANERA GENERAL A LA IDENTIFICACIÓN Y AISLAMIENTO DE CÉLULAS ÓTICAS HUMANAS; DE MANERA MÁS ESPECÍFICA, LA PRESENTE INVENCIÓN SE REFIERE A UN MÉTODO PARA USAR MARCADORES CELULARES PARA IDENTIFICAR Y AISLAR CÉLULAS PROGENITORAS ÓTICAS HUMANAS DE UNA POBLACIÓN MIXTA DE CÉLULAS, MÉTODO DE ENRIQUECIMIENTO Y PRODUCCIÓN DE CÉLULAS PROGENITORAS ÓTICAS HUMANAS, Y KITS ASOCIADOS PARA USARSE EN LA IDENTIFICACIÓN Y/O AISLAMIENTO DE CÉLULAS PROGENITORAS ÓTICAS HUMANAS, EN DONDE LOS MARCADORES CELULARES SE SELECCIONAN DE SSEA1 (CD15), DISIALOGANGLIÓSIDO GD3, TRA-2-49 (FOSFATASA ALCALINA EN HÍGADO/HUESO/RIÑÓN), SSEA4, GANGLIÓSIDO GD2 Y CD141.
CL2019000682A 2016-09-15 2019-03-15 Identificación y aislamiento del progenitor ótico humano. CL2019000682A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1615714.1A GB201615714D0 (en) 2016-09-15 2016-09-15 Otic progenitor identification and isolation

Publications (1)

Publication Number Publication Date
CL2019000682A1 true CL2019000682A1 (es) 2019-06-07

Family

ID=57288819

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019000682A CL2019000682A1 (es) 2016-09-15 2019-03-15 Identificación y aislamiento del progenitor ótico humano.

Country Status (28)

Country Link
US (2) US11634687B2 (es)
EP (1) EP3513191B1 (es)
JP (1) JP7134488B2 (es)
KR (1) KR102409178B1 (es)
CN (1) CN109716133B (es)
AU (1) AU2017328903B2 (es)
BR (1) BR112019004749A2 (es)
CA (1) CA3034529A1 (es)
CL (1) CL2019000682A1 (es)
CO (1) CO2019002095A2 (es)
CY (1) CY1124285T1 (es)
DK (1) DK3513191T3 (es)
ES (1) ES2877795T3 (es)
GB (1) GB201615714D0 (es)
HR (1) HRP20211049T1 (es)
HU (1) HUE055453T2 (es)
IL (1) IL265288B2 (es)
LT (1) LT3513191T (es)
MA (1) MA46424B1 (es)
MX (1) MX2019002995A (es)
PL (1) PL3513191T3 (es)
PT (1) PT3513191T (es)
RS (1) RS62083B1 (es)
RU (1) RU2768720C2 (es)
SG (1) SG11201901410SA (es)
SI (1) SI3513191T1 (es)
WO (1) WO2018051092A1 (es)
ZA (1) ZA201902342B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201615714D0 (en) * 2016-09-15 2016-11-02 Univ Of Sheffield The Otic progenitor identification and isolation
GB202213060D0 (en) 2022-09-07 2022-10-19 Rinri Therapeutics Ltd Surgical method for treatment of auditory disease or condition
GB202214291D0 (en) 2022-09-29 2022-11-16 Rinri Therapeutics Ltd Laminin culture protocol

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2379683A1 (en) 1999-07-20 2001-01-25 University Of Southern California Identification of pluripotent pre-mesenchymal, pre-hematopoietic progenitor cell
US6436704B1 (en) 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
US6534052B1 (en) 2000-09-05 2003-03-18 Yong-Fu Xiao Cardiac function comprising implantation of embryonic stem cell in which differentiation has been initiated
DE60230774D1 (de) 2001-04-20 2009-02-26 Children S Hospital Of Orange Isolierung von nervenstammzellen unter verwendung von gangliosiden und anderen oberflächenmarkern
US8673634B2 (en) 2003-11-13 2014-03-18 Massachusetts Eye & Ear Infirmary Method for the treatment of hearing loss
WO2007117573A2 (en) 2006-04-07 2007-10-18 Cold Spring Harbor Laboratory Transgenic mice for identifying and assessing neural stem/ progenitor cells
WO2008132722A1 (en) * 2007-04-26 2008-11-06 Ramot At Tel-Aviv University Ltd. Pluripotent autologous stem cells from oral mucosa and methods of use
GB2450747A (en) 2007-07-06 2009-01-07 Univ Sheffield Treatment of sensorineural hearing loss
RU2525223C2 (ru) * 2009-06-08 2014-08-10 Иалоджик Кореа Инк. Способ стимулирования области волосковых сенсорных клеток
EP2667881A4 (en) * 2011-01-24 2015-04-22 Univ Leland Stanford Junior METHODS OF GENERATING IN VITRO INTERNAL EAR CELLS
CA2864818C (en) * 2012-02-17 2022-05-03 The Schepens Eye Research Institute Phenotype profile of human retinal progenitor cells
WO2013188679A1 (en) 2012-06-13 2013-12-19 Stemgent, Inc. Methods of preparing pluripotent stem cells
GB201615714D0 (en) * 2016-09-15 2016-11-02 Univ Of Sheffield The Otic progenitor identification and isolation

Also Published As

Publication number Publication date
MA46424B1 (fr) 2021-07-29
LT3513191T (lt) 2021-08-10
AU2017328903B2 (en) 2023-07-06
ES2877795T3 (es) 2021-11-17
EP3513191B1 (en) 2021-04-28
SI3513191T1 (sl) 2021-09-30
CO2019002095A2 (es) 2019-05-31
EP3513191A1 (en) 2019-07-24
MX2019002995A (es) 2019-09-18
RU2019110990A3 (es) 2020-12-09
CN109716133B (zh) 2023-04-28
IL265288A (en) 2019-05-30
JP2019533138A (ja) 2019-11-14
HUE055453T2 (hu) 2021-11-29
SG11201901410SA (en) 2019-03-28
HRP20211049T1 (hr) 2021-10-01
US11634687B2 (en) 2023-04-25
KR20190051971A (ko) 2019-05-15
IL265288B1 (en) 2023-11-01
GB201615714D0 (en) 2016-11-02
CN109716133A (zh) 2019-05-03
PL3513191T3 (pl) 2021-10-25
IL265288B2 (en) 2024-03-01
US20230313134A1 (en) 2023-10-05
US20190185813A1 (en) 2019-06-20
ZA201902342B (en) 2021-09-29
PT3513191T (pt) 2021-07-05
MA46424A (fr) 2019-07-24
BR112019004749A2 (pt) 2019-05-28
RS62083B1 (sr) 2021-08-31
KR102409178B1 (ko) 2022-06-14
DK3513191T3 (da) 2021-07-05
RU2019110990A (ru) 2020-10-15
AU2017328903A1 (en) 2019-03-07
JP7134488B2 (ja) 2022-09-12
CY1124285T1 (el) 2022-07-22
WO2018051092A1 (en) 2018-03-22
CA3034529A1 (en) 2018-03-22
RU2768720C2 (ru) 2022-03-24

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