BR112018075984A2 - composição de distribuição de fármaco parenteral para liberação sustentada - Google Patents
composição de distribuição de fármaco parenteral para liberação sustentadaInfo
- Publication number
- BR112018075984A2 BR112018075984A2 BR112018075984-8A BR112018075984A BR112018075984A2 BR 112018075984 A2 BR112018075984 A2 BR 112018075984A2 BR 112018075984 A BR112018075984 A BR 112018075984A BR 112018075984 A2 BR112018075984 A2 BR 112018075984A2
- Authority
- BR
- Brazil
- Prior art keywords
- carvedilol
- release
- sustained release
- microparticles
- liposomes
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000013268 sustained release Methods 0.000 title abstract 2
- 239000012730 sustained-release form Substances 0.000 title abstract 2
- 238000012377 drug delivery Methods 0.000 title 1
- NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 abstract 4
- 229960004195 carvedilol Drugs 0.000 abstract 4
- 238000001990 intravenous administration Methods 0.000 abstract 2
- 239000002502 liposome Substances 0.000 abstract 2
- 239000011859 microparticle Substances 0.000 abstract 2
- 239000002105 nanoparticle Substances 0.000 abstract 2
- 239000007853 buffer solution Substances 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 238000013266 extended drug release Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000001802 infusion Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 238000007920 subcutaneous administration Methods 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
divulgam-se sistemas de liberação sustentada parenteral de carvedilol por infusão intravenosa (iv), injeção ou rotas subcutâneas. apresenta-se, na presente invenção, a preparação de sistemas de dispersão de carvedilol, tais como liposomas, nanopartículas ou micropartículas biodegradáveis e nanopartículas ou micropartículas poliméricas. composições contendo carvedilol encapsulado em lipossomas apresentaram maior biodisponibilidade e menor taxa de liberação do que a solução livre após administração intravenosa. a liberação in vitro desses lipossomas em soluções tampão demonstra liberação estendida de fármacos ao longo de 48 horas e, correspondentemente, dados de animais in vivo mostram que a administração parenteral de carvedilol encapsulado em materiais lipossomais tem perfil de liberação de pk sustentado.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662349390P | 2016-06-13 | 2016-06-13 | |
US62/349,390 | 2016-06-13 | ||
PCT/US2017/037311 WO2017218576A1 (en) | 2016-06-13 | 2017-06-13 | Parenteral sustained-release delivery of carvedilol disperse systems |
US15/621,844 | 2017-06-13 | ||
US15/621,844 US20170354592A1 (en) | 2016-06-13 | 2017-06-13 | Parenteral sustained-release delivery of carvedilol disperse systems |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018075984A2 true BR112018075984A2 (pt) | 2019-04-02 |
Family
ID=60573487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018075984-8A BR112018075984A2 (pt) | 2016-06-13 | 2017-06-13 | composição de distribuição de fármaco parenteral para liberação sustentada |
Country Status (8)
Country | Link |
---|---|
US (2) | US20170354592A1 (pt) |
EP (1) | EP3468539A4 (pt) |
JP (2) | JP2019521979A (pt) |
KR (1) | KR102474392B1 (pt) |
CN (1) | CN110381929A (pt) |
BR (1) | BR112018075984A2 (pt) |
CA (1) | CA3027368A1 (pt) |
WO (1) | WO2017218576A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170354592A1 (en) | 2016-06-13 | 2017-12-14 | Ascendia Pharmaceuticals, Llc | Parenteral sustained-release delivery of carvedilol disperse systems |
FI3962464T3 (fi) * | 2019-10-01 | 2023-05-24 | Evonik Corp | Menetelmä nanohiukkasten valmistamiseksi bioresorboituvaa polyesteriä käsittävän jauheen muodossa |
JP2021147329A (ja) * | 2020-03-16 | 2021-09-27 | 株式会社リコー | 粒子の製造方法 |
CN114159405B (zh) * | 2020-09-10 | 2023-06-23 | 上海中医药大学 | 一种在胃肠道内稳定的口服纳米粒子及其制备方法和应用 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX9203808A (es) | 1987-03-05 | 1992-07-01 | Liposome Co Inc | Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos. |
US5308862A (en) * | 1993-03-05 | 1994-05-03 | Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beecham Corp., Ltd. Partnership No. 1 | Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation |
US5576016A (en) | 1993-05-18 | 1996-11-19 | Pharmos Corporation | Solid fat nanoemulsions as drug delivery vehicles |
US5760069A (en) * | 1995-02-08 | 1998-06-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 | Method of treatment for decreasing mortality resulting from congestive heart failure |
US6664284B2 (en) | 1998-07-23 | 2003-12-16 | Roche Diagnostics Gmbh | Stabilized carvedilol injection solution |
WO2000012110A2 (en) | 1998-08-26 | 2000-03-09 | Queen's University At Kingston | Use of anti(w)pressor agents for vascular remodeling in genital dysfunction |
US7235237B2 (en) * | 1999-10-29 | 2007-06-26 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
ES2227206T3 (es) * | 2000-04-03 | 2005-04-01 | F. Hoffmann-La Roche Ag | Soluciones concentradas de carvedilol. |
AU2002337815A1 (en) * | 2001-10-05 | 2003-04-22 | Suwalee Chandrkrachang | Active agents using liposome beads |
US20040224012A1 (en) | 2001-10-05 | 2004-11-11 | Pichit Suvanprakorn | Topical application and methods for administration of active agents using liposome macro-beads |
AU2003287526A1 (en) | 2002-11-06 | 2004-06-03 | Protein-stabilized liposomal formulations of pharmaceutical agents | |
US20050143378A1 (en) | 2003-12-29 | 2005-06-30 | Yun Anthony J. | Treatment of conditions through pharmacological modulation of the autonomic nervous system |
EP1691789B1 (en) * | 2003-11-25 | 2017-12-20 | SmithKline Beecham (Cork) Limited | Carvedilol free base, salts, anhydrous forms or solvate thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods |
US8569277B2 (en) | 2004-08-11 | 2013-10-29 | Palo Alto Investors | Methods of treating a subject for a condition |
US8691877B2 (en) | 2004-10-15 | 2014-04-08 | Palo Alto Investors | Methods and compositions for treating a disease condition in a subject |
US8367112B2 (en) * | 2006-02-28 | 2013-02-05 | Alkermes Pharma Ireland Limited | Nanoparticulate carverdilol formulations |
US20090148498A1 (en) * | 2007-05-14 | 2009-06-11 | Sustained Nano Systems Llc | Controlled release implantable dispensing device and method |
CA2722743A1 (en) | 2008-04-28 | 2009-11-05 | Zogenix, Inc. | Novel formulations for treatment of migraine |
EP2680820B1 (en) | 2011-03-01 | 2022-11-02 | 2-BBB Medicines B.V. | Advanced active liposomal loading of poorly water-soluble substances |
WO2014018932A2 (en) * | 2012-07-27 | 2014-01-30 | Bunt Antonius Martinus Gustave | Effluz inhibitor compositions and methods of treatment using the same |
US20170354592A1 (en) | 2016-06-13 | 2017-12-14 | Ascendia Pharmaceuticals, Llc | Parenteral sustained-release delivery of carvedilol disperse systems |
-
2017
- 2017-06-13 US US15/621,844 patent/US20170354592A1/en not_active Abandoned
- 2017-06-13 CA CA3027368A patent/CA3027368A1/en active Pending
- 2017-06-13 BR BR112018075984-8A patent/BR112018075984A2/pt active Search and Examination
- 2017-06-13 WO PCT/US2017/037311 patent/WO2017218576A1/en unknown
- 2017-06-13 JP JP2018565290A patent/JP2019521979A/ja active Pending
- 2017-06-13 EP EP17813962.2A patent/EP3468539A4/en active Pending
- 2017-06-13 CN CN201780036949.9A patent/CN110381929A/zh active Pending
- 2017-06-21 KR KR1020197000045A patent/KR102474392B1/ko active IP Right Grant
-
2019
- 2019-06-03 US US16/429,693 patent/US10792244B2/en active Active
-
2022
- 2022-05-18 JP JP2022081399A patent/JP2022103337A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2022103337A (ja) | 2022-07-07 |
KR102474392B1 (ko) | 2022-12-07 |
JP2019521979A (ja) | 2019-08-08 |
US10792244B2 (en) | 2020-10-06 |
EP3468539A4 (en) | 2020-01-15 |
KR20190109376A (ko) | 2019-09-25 |
US20170354592A1 (en) | 2017-12-14 |
CA3027368A1 (en) | 2017-12-21 |
WO2017218576A1 (en) | 2017-12-21 |
CN110381929A (zh) | 2019-10-25 |
US20200000706A1 (en) | 2020-01-02 |
EP3468539A1 (en) | 2019-04-17 |
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Legal Events
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] |