BR112018072724A2 - composições e métodos para tecidos de bioengenharia - Google Patents
composições e métodos para tecidos de bioengenhariaInfo
- Publication number
- BR112018072724A2 BR112018072724A2 BR112018072724-5A BR112018072724A BR112018072724A2 BR 112018072724 A2 BR112018072724 A2 BR 112018072724A2 BR 112018072724 A BR112018072724 A BR 112018072724A BR 112018072724 A2 BR112018072724 A2 BR 112018072724A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- bioengineering
- fabrics
- compositions
- generation
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3625—Vascular tissue, e.g. heart valves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3633—Extracellular matrix [ECM]
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
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- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/28—Materials or treatment for tissue regeneration for liver reconstruction
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- C12N2500/00—Specific components of cell culture medium
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C12N2500/14—Calcium; Ca chelators; Calcitonin
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- C12N2500/24—Iron; Fe chelators; Transferrin
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- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
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- C12N2500/00—Specific components of cell culture medium
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- C12N2500/32—Amino acids
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- C12N2500/30—Organic components
- C12N2500/36—Lipids
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
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- C12N2501/998—Proteins not provided for elsewhere
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- C12N2533/54—Collagen; Gelatin
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- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
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Abstract
a presente divulgação proporciona métodos para a produção de tecido de bioengenharia ao longo do aparelho e outras composições relevantes empregadas na sua geração.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662335013P | 2016-05-11 | 2016-05-11 | |
US62/335,013 | 2016-05-11 | ||
US15/586,061 | 2017-05-03 | ||
US15/586,061 US20170369849A1 (en) | 2016-05-11 | 2017-05-03 | Compositions and methods for bioengineered tissues |
PCT/US2017/031320 WO2017196668A1 (en) | 2016-05-11 | 2017-05-05 | Compositions and methods for bioengineered tissues |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018072724A2 true BR112018072724A2 (pt) | 2019-02-19 |
Family
ID=58765912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018072724-5A BR112018072724A2 (pt) | 2016-05-11 | 2017-05-05 | composições e métodos para tecidos de bioengenharia |
Country Status (14)
Country | Link |
---|---|
US (2) | US20170369849A1 (pt) |
EP (1) | EP3455343A1 (pt) |
JP (2) | JP2019514391A (pt) |
KR (1) | KR20190008541A (pt) |
CN (1) | CN109415690A (pt) |
AU (1) | AU2017264583A1 (pt) |
BR (1) | BR112018072724A2 (pt) |
CA (1) | CA3022526A1 (pt) |
IL (1) | IL262564A (pt) |
MX (1) | MX2018013326A (pt) |
PH (1) | PH12018502303A1 (pt) |
RU (1) | RU2018142263A (pt) |
SG (1) | SG11201809474TA (pt) |
WO (1) | WO2017196668A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3612623B1 (en) | 2017-05-06 | 2024-07-03 | Upside Foods, Inc. | Compositions and methods for increasing the culture density of a cellular biomass within a cultivation infrastructure |
AU2018282728A1 (en) * | 2017-06-12 | 2020-01-30 | The University Of North Carolina At Chapel Hill | Patch graft compositions for cell engraftment |
US11479792B2 (en) | 2017-07-13 | 2022-10-25 | Upside Foods, Inc. | Compositions and methods for increasing the efficiency of cell cultures used for food production |
JP7483233B2 (ja) | 2019-03-29 | 2024-05-15 | 国立大学法人 長崎大学 | 培養組織及びその製造方法 |
KR102332433B1 (ko) * | 2020-01-13 | 2021-11-30 | 사회복지법인 삼성생명공익재단 | 조직 염색용 조성물 및 이를 이용한 조직 염색 방법 |
JP2022158210A (ja) * | 2021-04-01 | 2022-10-17 | 国立大学法人大阪大学 | 細胞凝集体を製造する方法 |
CN114324244B (zh) * | 2021-12-31 | 2023-11-07 | 浙江大学嘉兴研究院 | 基于弱相干干涉的生物膜胶原束取向光学检测方法和系统 |
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US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US6479064B1 (en) * | 1999-12-29 | 2002-11-12 | Children's Medical Center Corporation | Culturing different cell populations on a decellularized natural biostructure for organ reconstruction |
AU2005300263A1 (en) * | 2004-03-09 | 2006-05-11 | Jan-Eric W. Ahlfors | Autogenic living scaffolds and living tissue matrices: methods and uses thereof |
CN101258237A (zh) * | 2005-07-12 | 2008-09-03 | 特苏鲁尼斯公司 | 用于制备组织移植物的装置和方法 |
BRPI0618724A2 (pt) * | 2005-11-16 | 2011-09-06 | Univ North Carolina | componentes da matriz extracelular para expansão ou diferenciação de progenitores hepáticos |
CA2727535A1 (en) | 2007-06-15 | 2008-12-24 | University Of North Carolina At Chapel Hill | Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same |
US20130323708A1 (en) * | 2009-07-01 | 2013-12-05 | Massachusetts Institute Of Technology | Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same |
KR102230864B1 (ko) * | 2010-05-07 | 2021-03-23 | 유니버시티 오브 노스캐롤라이나 앳 채플 힐 | 고형 조직으로부터 세포를 생착시키는 방법 |
PT2588083T (pt) * | 2010-07-02 | 2017-06-26 | Univ North Carolina Chapel Hill | Estruturas de biomatriz |
EP2956538B1 (en) * | 2013-02-13 | 2018-11-14 | Wake Forest University Health Sciences | Bioengineered liver constructs and methods relating thereto |
JP6829078B2 (ja) * | 2014-03-14 | 2021-02-10 | ザ ジェネラル ホスピタル コーポレイション | 肺バイオリアクタ |
GB201409858D0 (en) * | 2014-06-03 | 2014-07-16 | Ucl Business Plc | Human liver scaffolds |
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2017
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- 2017-05-05 KR KR1020187034443A patent/KR20190008541A/ko not_active Application Discontinuation
- 2017-05-05 BR BR112018072724-5A patent/BR112018072724A2/pt not_active Application Discontinuation
- 2017-05-05 WO PCT/US2017/031320 patent/WO2017196668A1/en unknown
- 2017-05-05 AU AU2017264583A patent/AU2017264583A1/en not_active Abandoned
- 2017-05-05 MX MX2018013326A patent/MX2018013326A/es unknown
- 2017-05-05 EP EP17725394.5A patent/EP3455343A1/en active Pending
- 2017-05-05 CA CA3022526A patent/CA3022526A1/en active Pending
- 2017-05-05 CN CN201780042237.8A patent/CN109415690A/zh active Pending
- 2017-05-05 JP JP2018557094A patent/JP2019514391A/ja active Pending
- 2017-05-05 SG SG11201809474TA patent/SG11201809474TA/en unknown
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2018
- 2018-10-24 IL IL262564A patent/IL262564A/en unknown
- 2018-10-30 PH PH12018502303A patent/PH12018502303A1/en unknown
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2019
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2023
- 2023-01-13 JP JP2023003763A patent/JP2023055732A/ja active Pending
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MX2018013326A (es) | 2019-07-08 |
JP2019514391A (ja) | 2019-06-06 |
AU2017264583A1 (en) | 2018-12-06 |
RU2018142263A (ru) | 2020-06-01 |
CN109415690A (zh) | 2019-03-01 |
US20200080061A1 (en) | 2020-03-12 |
US20170369849A1 (en) | 2017-12-28 |
RU2018142263A3 (pt) | 2020-08-07 |
WO2017196668A1 (en) | 2017-11-16 |
PH12018502303A1 (en) | 2019-04-29 |
EP3455343A1 (en) | 2019-03-20 |
SG11201809474TA (en) | 2018-11-29 |
KR20190008541A (ko) | 2019-01-24 |
JP2023055732A (ja) | 2023-04-18 |
CA3022526A1 (en) | 2017-11-16 |
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