BR112018070634A2 - vacina universal para doenças virais - Google Patents

vacina universal para doenças virais

Info

Publication number
BR112018070634A2
BR112018070634A2 BR112018070634A BR112018070634A BR112018070634A2 BR 112018070634 A2 BR112018070634 A2 BR 112018070634A2 BR 112018070634 A BR112018070634 A BR 112018070634A BR 112018070634 A BR112018070634 A BR 112018070634A BR 112018070634 A2 BR112018070634 A2 BR 112018070634A2
Authority
BR
Brazil
Prior art keywords
polypeptides
virus
proteins
peptides
viral
Prior art date
Application number
BR112018070634A
Other languages
English (en)
Inventor
Romo Ana
Gérard Etienne Régulier Emmanuel
César Bellinzoni Rodolfo
Original Assignee
Biogenesis Bago Hong Kong Ltd
Biogenesis Bago Uruguay S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogenesis Bago Hong Kong Ltd, Biogenesis Bago Uruguay S A filed Critical Biogenesis Bago Hong Kong Ltd
Publication of BR112018070634A2 publication Critical patent/BR112018070634A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/135—Foot- and mouth-disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

a presente invenção refere-se a uma combinação farmacêutica para induzir uma ou mais respostas imunitárias e/ou para aumentar a efetividade da vacinação no hospedeiro, que é capaz de induzir proteção-cruzada contra cepas múltiplas e/ou serotipos de um vírus. numa modalidade, a combinação farmacêutica é capaz de gerar proteção em animais produtores de alimentos, tais como gado, ovelhas, cabras, suínos e outros animais de casco fendido com menos campanhas de vacinação. esta vacina universal compreende um vírus inativado com um ou mais dos seguintes componentes: polinucleotídeos codificando peptídeos, polipeptídeos ou proteínas virais em diferentes tipos de plasmídeos; peptídeos, polipeptídeos e proteínas virais; peptídeos e polipeptídeos virais sintéticos; peptídeos, polipeptídeos e proteínas virais recombinantes; partículas semelhantes a vírus; partículas semelhantes a vírus derivadas de outros vírus; proteínas utilizadas como carreadoras ou como adjuvante molecular fundido a peptídeos, polipeptídeos e/ou proteínas derivadas de vírus; adjuvantes; emulsificantes, adjuvantes moleculares e sistemas carreadores.
BR112018070634A 2016-04-11 2017-04-07 vacina universal para doenças virais BR112018070634A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662320852P 2016-04-11 2016-04-11
PCT/IB2017/052030 WO2017178945A1 (en) 2016-04-11 2017-04-07 Universal vaccine for viral diseases

Publications (1)

Publication Number Publication Date
BR112018070634A2 true BR112018070634A2 (pt) 2019-02-05

Family

ID=60041433

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018070634A BR112018070634A2 (pt) 2016-04-11 2017-04-07 vacina universal para doenças virais

Country Status (9)

Country Link
US (2) US10940196B2 (pt)
EP (1) EP3443097A4 (pt)
KR (1) KR20180132742A (pt)
CN (1) CN109196104B (pt)
AR (1) AR108014A1 (pt)
BR (1) BR112018070634A2 (pt)
TW (1) TWI763662B (pt)
UY (1) UY37198A (pt)
WO (1) WO2017178945A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3909970A1 (en) * 2020-05-14 2021-11-17 Consejo Superior De Investigaciones Científicas Peptide vaccines for the prevention of foot-and-mouth disease
CN111744000B (zh) * 2020-07-14 2021-03-23 中国农业科学院兰州兽医研究所 免疫抑制功能降低的口蹄疫重组病毒及其制备方法与应用
CN111978380A (zh) * 2020-09-02 2020-11-24 天康生物股份有限公司 野生型气肿疽梭菌细胞毒素a及其制备方法、应用和疫苗
CN114748617B (zh) * 2022-03-24 2024-04-16 华南农业大学 一种大口黑鲈虹彩病毒的亚单位疫苗及其制备方法和应用
CN114874338B (zh) * 2022-05-18 2024-04-12 华中农业大学 一种口蹄疫病毒纳米颗粒及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE303821T1 (de) * 2001-02-15 2005-09-15 Indian Inst Scient Neue vakzinformulierung aus dna-vakzine- inaktiviertem virus
CN1408434A (zh) * 2002-09-16 2003-04-09 复旦大学 抗家畜口蹄疫的多肽和dna联合疫苗及其制备方法
AR044603A1 (es) * 2004-06-03 2005-09-21 Consejo Nac Invest Cient Tec Proteinas quimericas aisladas de lumazina sintetasa modificada para la presentacion multiple de moleculas y sus aplicaciones
AU2010313132B2 (en) 2009-11-02 2015-01-15 Inovio Pharmaceuticals, Inc. Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom
CN101948811B (zh) * 2010-08-18 2013-01-09 中国农业科学院兰州兽医研究所 用反向遗传操作拓展口蹄疫疫苗株抗原谱及疫苗制备方法
CN102168088B (zh) * 2010-12-23 2012-12-26 中国农业科学院兰州兽医研究所 T细胞免疫原基因ti及其在口蹄疫蛋白亚单位疫苗和灭活疫苗中的应用
SG11201507253XA (en) * 2013-03-15 2015-10-29 Novavax Inc Enhanced expression of picornavirus proteins
CA2913702C (en) * 2013-05-27 2023-08-01 Inmunova S.A. Chimeras of brucella lumazine synthase and beta subunit of ab5 toxins
CN105056227B (zh) * 2015-07-21 2017-12-29 复旦大学 一种抗口蹄疫病毒的类病毒粒子vlp疫苗及其制备方法

Also Published As

Publication number Publication date
TWI763662B (zh) 2022-05-11
US20190142926A1 (en) 2019-05-16
UY37198A (es) 2017-11-30
CN109196104A (zh) 2019-01-11
TW201740973A (zh) 2017-12-01
US20210187096A1 (en) 2021-06-24
WO2017178945A1 (en) 2017-10-19
EP3443097A4 (en) 2020-04-22
CN109196104B (zh) 2023-01-31
EP3443097A1 (en) 2019-02-20
AR108014A1 (es) 2018-07-11
KR20180132742A (ko) 2018-12-12
US10940196B2 (en) 2021-03-09

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Legal Events

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B350 Update of information on the portal [chapter 15.35 patent gazette]
B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

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B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements