BR112018069854A2 - métodos para produzir proteína, xilo-oligossacarídeos e glicose, método para suprimir a diminuição na saturação de oxigênio dissolvido ao cultivar um fungo e composição de celulase - Google Patents
métodos para produzir proteína, xilo-oligossacarídeos e glicose, método para suprimir a diminuição na saturação de oxigênio dissolvido ao cultivar um fungo e composição de celulaseInfo
- Publication number
- BR112018069854A2 BR112018069854A2 BR112018069854A BR112018069854A BR112018069854A2 BR 112018069854 A2 BR112018069854 A2 BR 112018069854A2 BR 112018069854 A BR112018069854 A BR 112018069854A BR 112018069854 A BR112018069854 A BR 112018069854A BR 112018069854 A2 BR112018069854 A2 BR 112018069854A2
- Authority
- BR
- Brazil
- Prior art keywords
- fungus
- dissolved oxygen
- oxygen saturation
- cultivating
- xylo
- Prior art date
Links
- 241000233866 Fungi Species 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 3
- 229910052760 oxygen Inorganic materials 0.000 title abstract 3
- 239000001301 oxygen Substances 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108010059892 Cellulase Proteins 0.000 title 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 title 1
- 229940106157 cellulase Drugs 0.000 title 1
- 239000008103 glucose Substances 0.000 title 1
- 229920001542 oligosaccharide Polymers 0.000 title 1
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 abstract 2
- 241000223259 Trichoderma Species 0.000 abstract 2
- 229920002678 cellulose Polymers 0.000 abstract 2
- 239000001913 cellulose Substances 0.000 abstract 2
- 239000000411 inducer Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000002028 Biomass Substances 0.000 abstract 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 abstract 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
- 229920001221 xylan Polymers 0.000 abstract 1
- 150000004823 xylans Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/248—Xylanases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K1/00—Glucose; Glucose-containing syrups
- C13K1/02—Glucose; Glucose-containing syrups obtained by saccharification of cellulosic materials
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K13/00—Sugars not otherwise provided for in this class
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
é divulgado um método para produzir uma proteína com o uso de um fungo filamentoso, no qual a diminuição na saturação de oxigênio dissolvido durante a cultura do fungo filamentoso pode ser suprimida, mesmo quando a cultura tem aumento de escala. o método para produzir uma proteína inclui cultivar um fungo pertencente ao gênero trichoderma cujo gene bxl1 foi rompido, com o uso de uma biomassa contendo celulose e xilano como um indutor. o uso do fungo com gene bxl1 rompido pertencente ao gênero trichoderma permite a supressão da diminuição na saturação de oxigênio dissolvido, mesmo quando xilose e celulose são usadas como indutores.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016070584 | 2016-03-31 | ||
| PCT/JP2017/013377 WO2017170917A1 (ja) | 2016-03-31 | 2017-03-30 | タンパク質の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018069854A2 true BR112018069854A2 (pt) | 2019-01-29 |
Family
ID=59965909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018069854A BR112018069854A2 (pt) | 2016-03-31 | 2017-03-30 | métodos para produzir proteína, xilo-oligossacarídeos e glicose, método para suprimir a diminuição na saturação de oxigênio dissolvido ao cultivar um fungo e composição de celulase |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11453899B2 (pt) |
| EP (2) | EP3974527A1 (pt) |
| JP (2) | JP6319515B2 (pt) |
| CN (1) | CN108779456B (pt) |
| AU (1) | AU2017239832B2 (pt) |
| BR (1) | BR112018069854A2 (pt) |
| CA (1) | CA3019297A1 (pt) |
| PH (1) | PH12018502082A1 (pt) |
| WO (1) | WO2017170917A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI701249B (zh) * | 2015-03-13 | 2020-08-11 | 德商４Ｓｃ製藥公司 | Ｋv１.３抑制劑及其醫學應用 |
| JP6330972B2 (ja) | 2016-03-31 | 2018-05-30 | 東レ株式会社 | キシロオリゴ糖の製造方法 |
| JP7398371B2 (ja) * | 2018-07-04 | 2023-12-14 | 花王株式会社 | タンパク質の製造方法 |
| EP3831929A4 (en) * | 2018-07-30 | 2022-04-27 | Toray Industries, Inc. | MUTATION OF TRICHODERMA THREAD FUNGUS AND METHOD OF PRODUCING PROTEIN |
| CN111500619B (zh) * | 2019-01-31 | 2023-06-23 | 中国科学院分子植物科学卓越创新中心 | 一种bxl基因或其编码蛋白的应用 |
| JPWO2021153587A1 (pt) * | 2020-01-28 | 2021-08-05 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0731467A (ja) * | 1993-07-20 | 1995-02-03 | Mitsui Toatsu Chem Inc | 糸状菌の培養法 |
| CN1188510A (zh) * | 1995-06-23 | 1998-07-22 | 丹尼斯科成分公司(丹尼斯科公司) | 新的β-木糖苷酶和编码该酶的核苷酸序列以及该酶的用途 |
| US6300112B1 (en) * | 1995-06-23 | 2001-10-09 | Danisco Ingredients A.S (Danisco A/S) | β-xylosidase, nucleotide sequence encoding it, and use thereof |
| JP2009171885A (ja) * | 2008-01-23 | 2009-08-06 | Nippon Paper Industries Co Ltd | セルロース含有物から糖を製造する方法 |
| WO2009117689A1 (en) * | 2008-03-21 | 2009-09-24 | Danisco Us Inc., Genencor Division | Hemicellulase enriched compositions for enhancing hydrolysis of biomass |
| WO2010059424A2 (en) * | 2008-11-18 | 2010-05-27 | Novozymes, Inc. | Methods and compositions for degrading cellulosic material |
| DK2480660T5 (da) | 2009-09-23 | 2020-11-09 | Danisco Us Inc | Hidtil ukendte glycosylhydrolaseenzymer og anvendelser heraf |
| MX2012007224A (es) * | 2009-12-23 | 2012-07-30 | Danisco Us Inc | Metodos para mejorar la eficacia de las reacciones de sacarificacion y fermentacion simultaneas. |
| US10266832B2 (en) | 2010-08-25 | 2019-04-23 | Danisco Us Inc | Filamentous fungi having an altered viscosity phenotype |
| JP2014150745A (ja) * | 2013-02-06 | 2014-08-25 | Nagaoka Univ Of Technology | トリコデルマ属に属する微生物の変異株および該変異株の使用 |
| MY185323A (en) | 2013-02-20 | 2021-05-04 | Toray Industries | Sugar-solution production method |
| JPWO2014208493A1 (ja) * | 2013-06-25 | 2017-02-23 | 東レ株式会社 | 糖液の製造方法 |
| JP6458498B2 (ja) | 2013-08-22 | 2019-01-30 | 東レ株式会社 | 糖液の製造方法 |
| EP3088530B1 (en) | 2013-12-27 | 2020-04-29 | Toray Industries, Inc. | Method for producing sugar solution |
| CN115975994A (zh) | 2014-06-06 | 2023-04-18 | 诺维信公司 | 酶组合物及其用途 |
| US10041136B2 (en) * | 2014-07-10 | 2018-08-07 | The United States Of America As Represented By The Secretary Of Agriculture | Glycosyl hydrolase xylanases, compositions and methods of use for efficient hydrolysis and processing of xylan |
| AU2015337881B2 (en) * | 2014-10-31 | 2020-04-09 | Toray Industries, Inc. | Method for producing sugar solution and xylooligosaccharide |
| US20180002683A1 (en) * | 2014-12-18 | 2018-01-04 | Danisco Us Inc. | Engineered multifunctional enzymes and methods of use |
| WO2017170918A1 (ja) * | 2016-03-31 | 2017-10-05 | 東レ株式会社 | 変異型ｂｘｌ１遺伝子を有するトリコデルマ属真菌及びそれを使用したキシロオリゴ糖とグルコースの製造方法 |
| JP6330972B2 (ja) * | 2016-03-31 | 2018-05-30 | 東レ株式会社 | キシロオリゴ糖の製造方法 |
-
2017
- 2017-03-30 BR BR112018069854A patent/BR112018069854A2/pt unknown
- 2017-03-30 JP JP2017519022A patent/JP6319515B2/ja active Active
- 2017-03-30 AU AU2017239832A patent/AU2017239832B2/en active Active
- 2017-03-30 EP EP21205370.6A patent/EP3974527A1/en active Pending
- 2017-03-30 WO PCT/JP2017/013377 patent/WO2017170917A1/ja active Application Filing
- 2017-03-30 CN CN201780017453.7A patent/CN108779456B/zh active Active
- 2017-03-30 EP EP17775451.2A patent/EP3438262B1/en active Active
- 2017-03-30 CA CA3019297A patent/CA3019297A1/en active Pending
- 2017-03-30 US US16/088,950 patent/US11453899B2/en active Active
-
2018
- 2018-02-15 JP JP2018025165A patent/JP6939624B2/ja active Active
- 2018-09-27 PH PH12018502082A patent/PH12018502082A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017170917A1 (ja) | 2017-10-05 |
| EP3974527A1 (en) | 2022-03-30 |
| AU2017239832B2 (en) | 2023-04-27 |
| EP3438262B1 (en) | 2021-12-01 |
| AU2017239832A1 (en) | 2018-10-25 |
| CN108779456B (zh) | 2022-04-05 |
| EP3438262A4 (en) | 2019-09-04 |
| JP6319515B2 (ja) | 2018-05-09 |
| JP6939624B2 (ja) | 2021-09-22 |
| EP3438262A1 (en) | 2019-02-06 |
| JPWO2017170917A1 (ja) | 2018-04-05 |
| CN108779456A (zh) | 2018-11-09 |
| PH12018502082A1 (en) | 2019-07-08 |
| US20200165647A1 (en) | 2020-05-28 |
| US11453899B2 (en) | 2022-09-27 |
| CA3019297A1 (en) | 2017-10-05 |
| JP2018117620A (ja) | 2018-08-02 |
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