BR112018069438A2 - método para produzir 5- (bromometil) -1-benzotiofeno - Google Patents

método para produzir 5- (bromometil) -1-benzotiofeno

Info

Publication number
BR112018069438A2
BR112018069438A2 BR112018069438-0A BR112018069438A BR112018069438A2 BR 112018069438 A2 BR112018069438 A2 BR 112018069438A2 BR 112018069438 A BR112018069438 A BR 112018069438A BR 112018069438 A2 BR112018069438 A2 BR 112018069438A2
Authority
BR
Brazil
Prior art keywords
benzothiophene
bromomethyl
reactor
producing
present
Prior art date
Application number
BR112018069438-0A
Other languages
English (en)
Other versions
BR112018069438B1 (pt
Inventor
Ishihara Kentaro
Arai Tsuyoshi
Original Assignee
Toyama Chemical Co., Ltd.
Fujifilm Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co., Ltd., Fujifilm Corporation filed Critical Toyama Chemical Co., Ltd.
Publication of BR112018069438A2 publication Critical patent/BR112018069438A2/pt
Publication of BR112018069438B1 publication Critical patent/BR112018069438B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/12—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
    • B01J19/122—Incoherent waves
    • B01J19/123—Ultraviolet light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/12—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
    • B01J19/122—Incoherent waves
    • B01J19/127—Sunlight; Visible light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J2219/0873—Materials to be treated
    • B01J2219/0877—Liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J2219/12—Processes employing electromagnetic waves
    • B01J2219/1203—Incoherent waves

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

a presente invenção fornece um método para produzir industrialmente 5- (bromometil) -1-benzotiofeno. o método de produção de acordo com a presente invenção compreende: (1) uma etapa para introduzir 5-metil-1-benzotiofeno, um agente de bromação e um solvente num reator; (2) uma etapa para emitir luz tendo uma faixa de comprimentos de onda de 200-780 nm no interior do reator; e (3) uma etapa para recuperar 5- (bromometil) -1-benzotiofeno do reator.
BR112018069438-0A 2016-03-31 2017-03-30 Método para produzir 5- (bromometil) -1-benzotiofeno BR112018069438B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016-071574 2016-03-31
JP2016071574 2016-03-31
PCT/JP2017/013206 WO2017170850A1 (ja) 2016-03-31 2017-03-30 ５－ブロモメチル－１－ベンゾチオフェンの製造方法

Publications (2)

Publication Number Publication Date
BR112018069438A2 true BR112018069438A2 (pt) 2019-02-12
BR112018069438B1 BR112018069438B1 (pt) 2022-07-05

Family

ID=59965861

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018069438-0A BR112018069438B1 (pt) 2016-03-31 2017-03-30 Método para produzir 5- (bromometil) -1-benzotiofeno

Country Status (10)

Country Link
US (1) US11236062B2 (pt)
EP (1) EP3444243B1 (pt)
JP (1) JP6804520B2 (pt)
KR (1) KR102372969B1 (pt)
CN (1) CN109526218B (pt)
AU (1) AU2017239816B9 (pt)
BR (1) BR112018069438B1 (pt)
CA (1) CA3018486C (pt)
RU (1) RU2733381C2 (pt)
WO (1) WO2017170850A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11872556B2 (en) * 2019-03-05 2024-01-16 Dalian University Of Technology General-purpose fluorescent fluid photochemical microreactor and manufacturing method therefor by 3D printing
CN113480517B (zh) * 2021-07-30 2022-09-09 海南海神同洲制药有限公司 3-溴甲基-7-氯苯并[b]噻吩的合成方法
CN116903433A (zh) * 2023-07-12 2023-10-20 安徽科芯微流化工科技有限公司 一种微通道反应制备全氟溴辛烷的方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354066A (en) 1963-08-21 1967-11-21 Dow Chemical Co Allylic bromination process
US3567921A (en) * 1967-02-09 1971-03-02 Phillips Petroleum Co Apparatus for the continjous photohalogenation of hydrocarbons
GB1483349A (en) * 1974-02-28 1977-08-17 Croda Synthetic Chem Ltd Halogenation of heterocyclic compounds
US4046656A (en) * 1976-12-06 1977-09-06 The Dow Chemical Company Photochlorination process for methyl aromatic compounds
US4235685A (en) * 1979-09-04 1980-11-25 Ethyl Corporation Preparation of 3-thenyl bromide
JPS62138489A (ja) * 1985-12-12 1987-06-22 Tokuyama Soda Co Ltd 臭素化チオフエンの製造方法
EP0404721A3 (de) * 1989-06-20 1991-12-27 Ciba-Geigy Ag Mikrobizide Mittel
EP0595150B1 (de) * 1992-10-29 1996-07-31 Hoechst Aktiengesellschaft Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen
US5670582A (en) 1996-07-24 1997-09-23 Exxon Chemical Patents Inc. Process for halogenation of isomonoolefin/para-alkylstyrene copolymers
FR2771090B1 (fr) 1997-11-17 2000-02-04 Sanofi Sa Procede de preparation de derives de bromomethyl-biphenyle
US20030134880A1 (en) 2000-02-24 2003-07-17 Gordon Bruton Novel cd23 inhibitors
GB0011409D0 (en) 2000-05-11 2000-06-28 Smithkline Beecham Plc Novel compounds
PT1362854E (pt) * 2001-02-22 2008-01-21 Teijin Pharma Ltd Derivados benzo[b]tiofeno e processos para o produzir
US20050239780A1 (en) 2002-05-31 2005-10-27 Akira Suga Tetrahydropyran derivative
US7521462B2 (en) 2004-02-27 2009-04-21 Eli Lilly And Company 4-Amino-piperidine derivatives as monoamine uptake inhibitors
KR20050092885A (ko) 2004-03-17 2005-09-23 현대자동차주식회사 로프 후크 일체형 사이드 게이트 고정 장치
JP2006111553A (ja) 2004-10-13 2006-04-27 Dainippon Sumitomo Pharma Co Ltd スルホニルオキシインドール誘導体及びそれを含有する医薬組成物
EP1864978A4 (en) 2005-03-28 2009-07-01 Toyama Chemical Co Ltd PROCESS FOR PRODUCING 1- (3- (2- (1-BENZOTHIOPHEN-5-YL) -ETHOXY) PROPYL) AZETIDIN-3-OL OR ITS SALTS
KR20060104088A (ko) 2005-03-29 2006-10-09 삼성전자주식회사 표시 장치의 회로 기판 및 이를 포함하는 표시 장치
CA2652995A1 (en) 2006-05-22 2008-06-19 Merck & Co., Inc. Novel inhibitors of beta-lactamase
KR20080073142A (ko) 2007-02-05 2008-08-08 삼성전자주식회사 다결정 실리콘 박막의 제조방법
JP2013121923A (ja) 2011-12-09 2013-06-20 Mitsui Chemicals Agro Inc ４，４−ジフルオロ−３，４−ジヒドロイソキノリン類の製造法
JP6213553B2 (ja) 2013-02-13 2017-10-18 Jnc株式会社 ジフルオロメチレンオキシを有する液晶性化合物、液晶組成物および液晶表示素子

Also Published As

Publication number Publication date
CA3018486A1 (en) 2017-10-05
AU2017239816B9 (en) 2020-09-24
KR102372969B1 (ko) 2022-03-11
CA3018486C (en) 2024-02-20
WO2017170850A1 (ja) 2017-10-05
AU2017239816A1 (en) 2018-10-04
CN109526218A (zh) 2019-03-26
EP3444243B1 (en) 2020-09-02
EP3444243A4 (en) 2019-09-11
RU2018138147A3 (pt) 2020-05-27
AU2017239816B2 (en) 2020-09-17
JPWO2017170850A1 (ja) 2019-02-07
US20190119242A1 (en) 2019-04-25
BR112018069438B1 (pt) 2022-07-05
RU2733381C2 (ru) 2020-10-01
EP3444243A1 (en) 2019-02-20
CN109526218B (zh) 2021-07-06
JP6804520B2 (ja) 2020-12-23
RU2018138147A (ru) 2020-04-30
US11236062B2 (en) 2022-02-01
KR20180131544A (ko) 2018-12-10

Similar Documents

Publication Publication Date Title
SA518400053B1 (ar) عملية مُحسنة لإنتاج حمض أكريليك
CO2018001290A2 (es) Proceso para la producción de cannabidiol y delta-9-tetrahidrocannabinol
BR112017009806A2 (pt) sistema e método para gerar informações de nível de estresse e de nível de resiliência de estresse para um indivíduo
CO2022002637A2 (es) Proceso de fabricación de moduladores de cftr
GT201500348A (es) Compuestos de pirimidinodiona contra estados cardíacos
CO2020001927A2 (es) Método de producción de composiciones farmacéuticas que comprende el virus chikungunya inmunogénico chikv-delta5nsp3
BR112018069438A2 (pt) método para produzir 5- (bromometil) -1-benzotiofeno
CO2017010806A2 (es) Método para manufacturar compuesto novedoso que contiene nitrógeno o sal del mismo e intermediario de manufacturación del compuesto novedoso que contiene nitrógeno o sal del mismo
UY36406A (es) 4-oxo-3,4-dihidro-1,2,3-benzotriazinas como moduladores de gpr139
WO2015132673A3 (en) Methods for fabricating quantum dot polymer films
TW201612153A (en) Producing method of (R)-1,1,3-trimethyl-4-aminoindane
BR112018001382A2 (pt) processo para produzir composição polimerizável para material óptico e composição polimerizável para material óptico
BR112016017570A2 (pt) Borracha estabilizada, processo para preparar as borrachas estabilizadas, mistura vulcanizável, processo para a preparação da mistura vulcanizável, processo para preparar vulcanizados da mistura vulcanizável, e, vulcanizado
BR112017004233A2 (pt) polipeptídeos tendo atividade de xilanase com uma alta taxa de conversão de polissacarídeos contendo xilose
ECSP18055921A (es) Cocristal, método de producción del mismo, y medicamento que contiene dicho cocristal
CO2018007008A2 (es) "procesos mejorados para la preparación de osimertinib (azd9291) o una sal del mismo y "azd9291 anilina" o una sal del mismo"
DOP2016000211A (es) Pirazinas moduladoras de gpr6
TW201614012A (en) Image forming material and image forming method
BR112018003826A2 (pt) utilização de pelo menos um solvente, processo para a recuperação de pelo menos um derivado de ácido (tio)fosfórico e mistura
AR099066A1 (es) Polímeros que comprenden grupos de ácido sulfónico
BR112017023508A2 (pt) processo para produção de uma composição de polímero reforçado com fibras, produto, e, uso de um tecido não tecido.
MX2020013117A (es) Procesos para la preparacion de sugammadex.
AR104145A1 (es) Método de producción de epirrubicina, intermediario y sal farmacéutica
CO2019010117A2 (es) Proceso para la separación de isómeros ópticos de etilésteres racémicos del ácido 3-alquilpiperidin-carboxílico
MY196769A (en) Synthesis of a thiosulfonic acid by a step of periodate mediated oxidative coupling of a thiosulfonic acid with an aniline

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: FUJIFILM CORPORATION (JP) ; FUJIFILM TOYAMA CHEMIC

B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/03/2017, OBSERVADAS AS CONDICOES LEGAIS