BR112018068247A2 - novas junções de três vias de prna - Google Patents

novas junções de três vias de prna

Info

Publication number
BR112018068247A2
BR112018068247A2 BR112018068247A BR112018068247A BR112018068247A2 BR 112018068247 A2 BR112018068247 A2 BR 112018068247A2 BR 112018068247 A BR112018068247 A BR 112018068247A BR 112018068247 A BR112018068247 A BR 112018068247A BR 112018068247 A2 BR112018068247 A2 BR 112018068247A2
Authority
BR
Brazil
Prior art keywords
prna
new
way joints
way
joints
Prior art date
Application number
BR112018068247A
Other languages
English (en)
Inventor
C Hill Alyssa
J Schroeder Susan
Original Assignee
C Hill Alyssa
Univ Oklahoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C Hill Alyssa, Univ Oklahoma filed Critical C Hill Alyssa
Publication of BR112018068247A2 publication Critical patent/BR112018068247A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/52—Physical structure branched
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

Abstract

são descritos arcabouços de rna de junção de três vias (3wj) derivados de prnas phi29, m2, sf5 e ga1 e que possuem estabilidade elevada. os arcabouços de prna de 3wj podem ser usados para formar compostos, conjugados, composições e nanopartículas para a liberação de agentes ativos para funções terapêutica se/ou diagnósticas.
BR112018068247A 2016-02-26 2017-02-26 novas junções de três vias de prna BR112018068247A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662300517P 2016-02-26 2016-02-26
PCT/US2017/019556 WO2017147557A1 (en) 2016-02-26 2017-02-26 Novel prna three-way junctions

Publications (1)

Publication Number Publication Date
BR112018068247A2 true BR112018068247A2 (pt) 2019-01-15

Family

ID=59685710

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018068247A BR112018068247A2 (pt) 2016-02-26 2017-02-26 novas junções de três vias de prna

Country Status (10)

Country Link
US (1) US10900035B2 (pt)
EP (1) EP3419988A4 (pt)
JP (1) JP2019510511A (pt)
CN (1) CN109071591A (pt)
AU (1) AU2017222690A1 (pt)
BR (1) BR112018068247A2 (pt)
CA (1) CA3015667A1 (pt)
IL (1) IL261368A (pt)
SG (1) SG11201807225VA (pt)
WO (1) WO2017147557A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3615085A4 (en) * 2018-02-09 2021-01-13 Ohio State Innovation Foundation RNA NANOSTRUCTURES, THEIR MANUFACTURING PROCESSES AND THEIR USES
WO2019166877A1 (en) * 2018-03-02 2019-09-06 Sixfold Bioscience Ltd. Compositions for delivery of cargo to cells
JP7267416B2 (ja) * 2018-07-12 2023-05-01 百薬智達（北京）納米生物技術有限公司 核酸ナノ粒子、それを含む薬学的組成物、アドリアマイシン含有薬物及びその製造方法
JP2023523345A (ja) 2020-04-27 2023-06-02 シックスフォールド バイオサイエンス リミテッド モジュール官能基を有する核酸ナノ粒子を含有する組成物
WO2024069235A2 (en) 2022-09-30 2024-04-04 Sixfold Bioscience Ltd. Compositions containing oligonucleotides with theranostic applications

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2291342T3 (es) * 2000-08-23 2008-03-01 Purdue Research Foundation Quimera de arnp.
US20050266416A1 (en) * 2002-09-18 2005-12-01 Purdue Research Foundation Molecular nanomotor
US9732337B2 (en) * 2009-06-16 2017-08-15 The United Stated of America, as represented by the Secretary, Department of Health & Human Services RNA nanoparticles and nanotubes
WO2012094586A2 (en) * 2011-01-07 2012-07-12 Peixuan Guo Synthetic non-covalently self-assembling bipartite prna chimeras
WO2012170372A2 (en) * 2011-06-08 2012-12-13 University Of Cincinnati Prna mutlivalent junction domain for use in stable multivalent rna nanoparticles
WO2015196146A2 (en) 2014-06-19 2015-12-23 University Of Kentucky Research Foundation Rna-based compositions and adjuvants for prophylactic and therapeutic treatment

Also Published As

Publication number Publication date
US20190055551A1 (en) 2019-02-21
JP2019510511A (ja) 2019-04-18
CN109071591A (zh) 2018-12-21
US10900035B2 (en) 2021-01-26
IL261368A (en) 2018-10-31
SG11201807225VA (en) 2018-09-27
EP3419988A1 (en) 2019-01-02
WO2017147557A1 (en) 2017-08-31
AU2017222690A1 (en) 2018-09-13
EP3419988A4 (en) 2019-11-27
CA3015667A1 (en) 2017-08-31
WO2017147557A8 (en) 2018-10-04

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]