BR112018014349A2 - métodos para sequenciar material genômico, para sequenciar dna em uma amostra, para reduzir mutações introduzidas por pcr e para tratar câncer, e métodos de sequenciamento de dna em uma amostra e sequenciamento representacional direcionado - Google Patents

métodos para sequenciar material genômico, para sequenciar dna em uma amostra, para reduzir mutações introduzidas por pcr e para tratar câncer, e métodos de sequenciamento de dna em uma amostra e sequenciamento representacional direcionado

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Publication number
BR112018014349A2
BR112018014349A2 BR112018014349A BR112018014349A BR112018014349A2 BR 112018014349 A2 BR112018014349 A2 BR 112018014349A2 BR 112018014349 A BR112018014349 A BR 112018014349A BR 112018014349 A BR112018014349 A BR 112018014349A BR 112018014349 A2 BR112018014349 A2 BR 112018014349A2
Authority
BR
Brazil
Prior art keywords
sequencing
sample
methods
dna
directed
Prior art date
Application number
BR112018014349A
Other languages
English (en)
Inventor
Burgess Daniel
Rosenbaum Heidi
Alexander Nelson
Stanislaw Stacey
Original Assignee
Hoffmann La Roche
Ventana Med Syst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, Ventana Med Syst Inc filed Critical Hoffmann La Roche
Publication of BR112018014349A2 publication Critical patent/BR112018014349A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/146—Concentration of target or template
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/113—PCR

Abstract

em um aspecto da presente divulgação está um fluxo de trabalho de sequenciamento direcionado, onde uma amostra de entrada que compreende uma quantidade suficiente de material genômico é fornecida, de modo que o mínimo de ciclos ou nenhum ciclo de amplificação é utilizado antes do sequenciamento.
BR112018014349A 2016-01-15 2016-11-07 métodos para sequenciar material genômico, para sequenciar dna em uma amostra, para reduzir mutações introduzidas por pcr e para tratar câncer, e métodos de sequenciamento de dna em uma amostra e sequenciamento representacional direcionado BR112018014349A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662279126P 2016-01-15 2016-01-15
US201662415952P 2016-11-01 2016-11-01
PCT/US2016/060835 WO2017123316A1 (en) 2016-01-15 2016-11-07 Deep sequencing profiling of tumors

Publications (1)

Publication Number Publication Date
BR112018014349A2 true BR112018014349A2 (pt) 2019-02-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018014349A BR112018014349A2 (pt) 2016-01-15 2016-11-07 métodos para sequenciar material genômico, para sequenciar dna em uma amostra, para reduzir mutações introduzidas por pcr e para tratar câncer, e métodos de sequenciamento de dna em uma amostra e sequenciamento representacional direcionado

Country Status (13)

Country Link
US (2) US11649492B2 (pt)
EP (1) EP3402896B1 (pt)
JP (2) JP7232643B2 (pt)
KR (1) KR102398465B1 (pt)
CN (1) CN108463559A (pt)
AU (1) AU2016386032B2 (pt)
BR (1) BR112018014349A2 (pt)
CA (1) CA3011342C (pt)
IL (1) IL260304A (pt)
SA (1) SA518392005B1 (pt)
SG (1) SG11201805600VA (pt)
WO (1) WO2017123316A1 (pt)
ZA (1) ZA201804322B (pt)

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WO2017027653A1 (en) 2015-08-11 2017-02-16 The Johns Hopkins University Assaying ovarian cyst fluid
CN108463559A (zh) * 2016-01-15 2018-08-28 文塔纳医疗系统公司 肿瘤的深度测序概况分析
JP7232476B2 (ja) 2017-08-07 2023-03-08 ザ ジョンズ ホプキンス ユニバーシティ がんを評価及び治療するための方法及び物質
US20200004928A1 (en) 2018-06-29 2020-01-02 Roche Sequencing Solutions, Inc. Computing device with improved user interface for interpreting and visualizing data
CN109234356B (zh) * 2018-09-18 2021-10-08 南京迪康金诺生物技术有限公司 一种构建杂交捕获测序文库的方法及应用
WO2020112566A1 (en) 2018-11-29 2020-06-04 Ventana Medical Systems, Inc. Personalized ctdna disease monitoring via representative dna sequencing
EP3899951A1 (en) 2018-12-23 2021-10-27 F. Hoffmann-La Roche AG Tumor classification based on predicted tumor mutational burden
EP3984037A1 (en) 2019-06-13 2022-04-20 F. Hoffmann-La Roche AG Systems and methods with improved user interface for interpreting and visualizing longitudinal data
KR20240011699A (ko) 2021-05-20 2024-01-26 에이지씨 가부시키가이샤 폴리카보네이트의 제조 방법

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Also Published As

Publication number Publication date
AU2016386032A1 (en) 2018-07-12
CN108463559A (zh) 2018-08-28
ZA201804322B (en) 2022-10-26
JP7379418B2 (ja) 2023-11-14
US20230250476A1 (en) 2023-08-10
US20180320229A1 (en) 2018-11-08
JP2019503182A (ja) 2019-02-07
CA3011342A1 (en) 2017-07-20
EP3402896A1 (en) 2018-11-21
KR102398465B1 (ko) 2022-05-13
SA518392005B1 (ar) 2022-02-08
AU2016386032B2 (en) 2021-08-12
KR20180098412A (ko) 2018-09-03
WO2017123316A1 (en) 2017-07-20
JP2021176302A (ja) 2021-11-11
EP3402896B1 (en) 2021-03-31
IL260304A (en) 2018-08-30
JP7232643B2 (ja) 2023-03-03
SG11201805600VA (en) 2018-07-30
CA3011342C (en) 2023-03-14
US11649492B2 (en) 2023-05-16

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