BR112018013570A2 - inibidores de il-8 para uso no tratamento de neuropatia periférica induzida por quimioterapia - Google Patents
inibidores de il-8 para uso no tratamento de neuropatia periférica induzida por quimioterapiaInfo
- Publication number
- BR112018013570A2 BR112018013570A2 BR112018013570A BR112018013570A BR112018013570A2 BR 112018013570 A2 BR112018013570 A2 BR 112018013570A2 BR 112018013570 A BR112018013570 A BR 112018013570A BR 112018013570 A BR112018013570 A BR 112018013570A BR 112018013570 A2 BR112018013570 A2 BR 112018013570A2
- Authority
- BR
- Brazil
- Prior art keywords
- chemotherapy
- treatment
- inhibitors
- peripheral neuropathy
- induced
- Prior art date
Links
- 238000002512 chemotherapy Methods 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 208000033808 peripheral neuropathy Diseases 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 abstract 2
- 108010018976 Interleukin-8A Receptors Proteins 0.000 abstract 1
- 108010018951 Interleukin-8B Receptors Proteins 0.000 abstract 1
- 102000002791 Interleukin-8B Receptors Human genes 0.000 abstract 1
- 206010061323 Optic neuropathy Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 208000020911 optic nerve disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
a presente invenção se refere a compostos inibidores de il-8, de preferência de inibidores da dupla de receptores cxcr1 / cxcr2, úteis no tratamento e / ou prevenção de neuropatia induzida por quimioterapia, de preferência, no tratamento e / ou prevenção da neuropatia periférica induzida por quimioterapia (npiq) ou neuropatia óptica induzida por quimioterapia.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16151618.2 | 2016-01-15 | ||
| EP16151618.2A EP3192504A1 (en) | 2016-01-15 | 2016-01-15 | Il-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy |
| EP16190871 | 2016-09-27 | ||
| EP16190871.0 | 2016-09-27 | ||
| PCT/EP2017/050637 WO2017121838A1 (en) | 2016-01-15 | 2017-01-13 | Il-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112018013570A2 true BR112018013570A2 (pt) | 2018-12-11 |
| BR112018013570B1 BR112018013570B1 (pt) | 2023-08-08 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019501948A (ja) | 2019-01-24 |
| CN108463219B (zh) | 2021-09-17 |
| RS62427B1 (sr) | 2021-11-30 |
| EP3402474B1 (en) | 2021-07-21 |
| PL3402474T3 (pl) | 2021-12-27 |
| DK3402474T3 (da) | 2021-10-11 |
| HRP20211527T1 (hr) | 2021-12-24 |
| CA3009438A1 (en) | 2017-07-20 |
| SG11201804484YA (en) | 2018-07-30 |
| US20190015391A1 (en) | 2019-01-17 |
| CY1125297T1 (el) | 2023-03-24 |
| CN108463219A (zh) | 2018-08-28 |
| ZA201803486B (en) | 2019-09-25 |
| EP3402474A1 (en) | 2018-11-21 |
| SI3402474T1 (sl) | 2021-12-31 |
| AU2017207850B2 (en) | 2022-06-30 |
| ES2893701T3 (es) | 2022-02-09 |
| MA43861A (fr) | 2021-05-05 |
| HUE056606T2 (hu) | 2022-02-28 |
| AU2017207850A1 (en) | 2018-06-21 |
| WO2017121838A1 (en) | 2017-07-20 |
| JP7049254B2 (ja) | 2022-04-06 |
| MX2018008614A (es) | 2018-11-19 |
| IL260373B (en) | 2021-03-25 |
| LT3402474T (lt) | 2021-11-25 |
| KR20180101390A (ko) | 2018-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.23 NA RPI NO 2623 DE 13/04/2021 POR TER SIDO INDEVIDA. |
|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/01/2017, OBSERVADAS AS CONDICOES LEGAIS |