BR112018011456A2 - sistema de ultrassom para insonificar uma região de interesse - Google Patents

sistema de ultrassom para insonificar uma região de interesse

Info

Publication number
BR112018011456A2
BR112018011456A2 BR112018011456A BR112018011456A BR112018011456A2 BR 112018011456 A2 BR112018011456 A2 BR 112018011456A2 BR 112018011456 A BR112018011456 A BR 112018011456A BR 112018011456 A BR112018011456 A BR 112018011456A BR 112018011456 A2 BR112018011456 A2 BR 112018011456A2
Authority
BR
Brazil
Prior art keywords
rav
beams
ultrasound
technique
ultrasound system
Prior art date
Application number
BR112018011456A
Other languages
English (en)
Other versions
BR112018011456B1 (pt
Inventor
Jean-Marie Gaud Emmanuel
Paul Robert Hyvelin Jean-Marc
Earl Powers Jeffry
Seip Ralf
William Dianis Scott
Tao Shi William
Bohren Yannick
Original Assignee
Bracco Suisse Sa
Koninklijke Philips Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse Sa, Koninklijke Philips Nv filed Critical Bracco Suisse Sa
Publication of BR112018011456A2 publication Critical patent/BR112018011456A2/pt
Publication of BR112018011456B1 publication Critical patent/BR112018011456B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/06—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/13—Tomography
    • A61B8/14—Echo-tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00106—Sensing or detecting at the treatment site ultrasonic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B2017/22005—Effects, e.g. on tissue
    • A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
    • A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B2017/22027—Features of transducers
    • A61B2017/22028—Features of transducers arrays, e.g. phased arrays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/488—Diagnostic techniques involving Doppler signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0039—Ultrasound therapy using microbubbles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0082—Scanning transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0095—Beam steering by modifying an excitation signal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A61N2007/027—Localised ultrasound hyperthermia with multiple foci created simultaneously

Abstract

trata-se de um sistema de ultrassom terapêutico que transmite um padrão alternado ou intercalado de feixes de terapia para uso em sonotrombólise e outra terapia mediada por ressonadores acústicos vasculares (rav). a técnica da invenção minimiza o rav, por exemplo, microbolha, destruição devido a feixes adjacentes, assegura a sonicação uniforme da região-alvo pelo preenchimento dos espaços entre os feixes em passagens subsequentes e fornece adicionalmente um meio para reabastecimento de bolhas para maximizar a lise do coágulo a partir do ultrassom. a técnica também é aplicável a ultrassom de diagnóstico, aplicação de medicamentos mediada por rav e abertura da barreira hematoencefálica.
BR112018011456-1A 2015-12-09 2016-12-07 Sistema de ultrassom para insonificar uma região de interesse BR112018011456B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562265154P 2015-12-09 2015-12-09
US62/265,154 2015-12-09
EP16155298.9 2016-02-11
EP16155298 2016-02-11
PCT/EP2016/080127 WO2017097853A1 (en) 2015-12-09 2016-12-07 Interleaved beam pattern for sonothrombolysis and other vascular acoustic resonator mediated therapies

Publications (2)

Publication Number Publication Date
BR112018011456A2 true BR112018011456A2 (pt) 2018-11-27
BR112018011456B1 BR112018011456B1 (pt) 2024-01-09

Family

ID=55361368

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018011456-1A BR112018011456B1 (pt) 2015-12-09 2016-12-07 Sistema de ultrassom para insonificar uma região de interesse

Country Status (7)

Country Link
US (1) US11284910B2 (pt)
EP (1) EP3386589B1 (pt)
JP (2) JP2018538056A (pt)
CN (1) CN108601948B (pt)
BR (1) BR112018011456B1 (pt)
CA (1) CA3007514C (pt)
WO (1) WO2017097853A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107864633A (zh) 2014-12-19 2018-03-30 皮埃尔与玛丽·居里-巴黎第六大学 用于脑治疗的可植入的超声发生治疗装置、包括此装置的设备以及实施此装置的方法
CN109414595A (zh) 2016-03-11 2019-03-01 索邦大学 用于脊髓和/或脊神经治疗的可植入超声产生治疗装置、包括该装置的设备及方法
EP3426157B1 (en) 2016-03-11 2022-02-16 Sorbonne Universite External ultrasound generating treating device for spinal cord and spinal nerves treatment
US11400168B2 (en) 2017-12-07 2022-08-02 California Institute Of Technology Methods and systems for noninvasive control of brain cells and related vectors and compositions
JP2022500093A (ja) * 2018-06-06 2022-01-04 インサイテック・リミテッド キャビテーションの最適化された監視を伴う集束超音波システム
CN112370079B (zh) * 2020-11-18 2022-08-26 景德镇陶瓷大学 一种利用超声多普勒检测血栓的方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN172208B (pt) 1990-04-02 1993-05-01 Sint Sa
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
AU636481B2 (en) 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
US6333021B1 (en) 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US6071239A (en) * 1997-10-27 2000-06-06 Cribbs; Robert W. Method and apparatus for lipolytic therapy using ultrasound energy
US6013032A (en) 1998-03-13 2000-01-11 Hewlett-Packard Company Beamforming methods and apparatus for three-dimensional ultrasound imaging using two-dimensional transducer array
US5997479A (en) 1998-05-28 1999-12-07 Hewlett-Packard Company Phased array acoustic systems with intra-group processors
US6530885B1 (en) 2000-03-17 2003-03-11 Atl Ultrasound, Inc. Spatially compounded three dimensional ultrasonic images
US6468216B1 (en) 2000-08-24 2002-10-22 Kininklijke Philips Electronics N.V. Ultrasonic diagnostic imaging of the coronary arteries
US6723050B2 (en) 2001-12-19 2004-04-20 Koninklijke Philips Electronics N.V. Volume rendered three dimensional ultrasonic images with polar coordinates
CA2476873A1 (en) * 2002-02-20 2003-08-28 Liposonix, Inc. Ultrasonic treatment and imaging of adipose tissue
WO2004069284A2 (en) 2003-02-04 2004-08-19 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
AU2004272023B2 (en) 2003-09-08 2008-06-26 Board Of Trustees Of The University Of Arkansas Ultrasound apparatus and method for augmented clot lysis
US7857773B2 (en) * 2003-12-30 2010-12-28 Medicis Technologies Corporation Apparatus and methods for the destruction of adipose tissue
US20080234580A1 (en) 2004-02-05 2008-09-25 Koninklijke Philips Electronics, N.V. Ultrasonic Imaging of Perfusion and Blood Flow with Harmonic Contrast Agents
US7806839B2 (en) * 2004-06-14 2010-10-05 Ethicon Endo-Surgery, Inc. System and method for ultrasound therapy using grating lobes
WO2007047726A2 (en) * 2005-10-20 2007-04-26 The General Hospital Corporation Non-invasive treatment of fascia
WO2007058668A1 (en) 2005-11-18 2007-05-24 Imarx Therapeutics, Inc. Ultrasound apparatus and method to treat an ischemic stroke
US8235901B2 (en) * 2006-04-26 2012-08-07 Insightec, Ltd. Focused ultrasound system with far field tail suppression
US20100016707A1 (en) * 2006-08-08 2010-01-21 Keter Medical Ltd Imaging system
CN101500651B (zh) 2006-08-11 2012-08-08 皇家飞利浦电子股份有限公司 用于颅脑血流成像和微泡加强血块溶解的超声系统
US20080097206A1 (en) * 2006-09-27 2008-04-24 Chomas James E Enhanced contrast agent augmented ultrasound thrombus treatment
US20100056924A1 (en) * 2006-11-20 2010-03-04 Koninklijke Philips Electronics N.V. Control and display of ultrasonic microbubble cavitation
US20100160781A1 (en) * 2008-12-09 2010-06-24 University Of Washington Doppler and image guided device for negative feedback phased array hifu treatment of vascularized lesions
TW201034628A (en) * 2009-03-04 2010-10-01 Medicis Technologies Corp Ultrasonic treatment of adipose tissue at multiple depths
WO2010108104A1 (en) 2009-03-20 2010-09-23 University Of Cincinnati Ultrasound-mediated inducement, detection, and enhancement of stable cavitation
US9149658B2 (en) * 2010-08-02 2015-10-06 Guided Therapy Systems, Llc Systems and methods for ultrasound treatment
WO2014146022A2 (en) * 2013-03-15 2014-09-18 Guided Therapy Systems Llc Ultrasound treatment device and methods of use
BR112015032732B1 (pt) * 2013-07-03 2022-05-17 Bracco Suisse S.A. Sistema para tratamento ultrassônico de acidente vascular cerebral

Also Published As

Publication number Publication date
US11284910B2 (en) 2022-03-29
EP3386589B1 (en) 2022-02-09
BR112018011456B1 (pt) 2024-01-09
CA3007514A1 (en) 2017-06-15
CA3007514C (en) 2024-03-19
CN108601948A (zh) 2018-09-28
WO2017097853A1 (en) 2017-06-15
JP2018538056A (ja) 2018-12-27
US20180353777A1 (en) 2018-12-13
EP3386589A1 (en) 2018-10-17
JP2023036759A (ja) 2023-03-14
CN108601948B (zh) 2021-04-20

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Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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