BR112018010024A2 - compostos e composições úteis no tratamento de distúrbios relacionados a ntrk - Google Patents

compostos e composições úteis no tratamento de distúrbios relacionados a ntrk

Info

Publication number
BR112018010024A2
BR112018010024A2 BR112018010024A BR112018010024A BR112018010024A2 BR 112018010024 A2 BR112018010024 A2 BR 112018010024A2 BR 112018010024 A BR112018010024 A BR 112018010024A BR 112018010024 A BR112018010024 A BR 112018010024A BR 112018010024 A2 BR112018010024 A2 BR 112018010024A2
Authority
BR
Brazil
Prior art keywords
ntrk
compounds
treatment
related disorders
compositions useful
Prior art date
Application number
BR112018010024A
Other languages
English (en)
Other versions
BR112018010024A8 (pt
Inventor
V Miduturu Chandrasekhar
L Kim Joseph
Bifulco Neil Jr
Mark Wenglowsky Steven
Original Assignee
Blueprint Medicines Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blueprint Medicines Corp filed Critical Blueprint Medicines Corp
Publication of BR112018010024A2 publication Critical patent/BR112018010024A2/pt
Publication of BR112018010024A8 publication Critical patent/BR112018010024A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

a presente invenção se refere a inibidores de ntrk que compreendem uma estrutura pirazolo[1,5-4]pirimidina-3-carbonitrila. eles são ativos contra ntrk de tipo selvagem e seus mutantes resistentes.
BR112018010024A 2015-11-19 2016-11-18 compostos e composições úteis no tratamento de distúrbios relacionados a ntrk BR112018010024A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562257476P 2015-11-19 2015-11-19
PCT/US2016/062731 WO2017087778A1 (en) 2015-11-19 2016-11-18 Compounds and compositions useful for treating disorders related to ntrk

Publications (2)

Publication Number Publication Date
BR112018010024A2 true BR112018010024A2 (pt) 2018-11-21
BR112018010024A8 BR112018010024A8 (pt) 2019-02-26

Family

ID=57517997

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018010024A BR112018010024A8 (pt) 2015-11-19 2016-11-18 compostos e composições úteis no tratamento de distúrbios relacionados a ntrk

Country Status (18)

Country Link
US (2) US10370379B2 (pt)
EP (1) EP3377497A1 (pt)
JP (1) JP2019500328A (pt)
KR (1) KR20180081790A (pt)
CN (1) CN108431008A (pt)
AR (1) AR106756A1 (pt)
AU (1) AU2016355196A1 (pt)
BR (1) BR112018010024A8 (pt)
CA (1) CA3005741A1 (pt)
HK (1) HK1259453A1 (pt)
IL (1) IL259164A (pt)
MX (1) MX2018006195A (pt)
PH (1) PH12018501065A1 (pt)
RU (1) RU2018122089A (pt)
SG (2) SG11201803920TA (pt)
TW (1) TWI733713B (pt)
WO (1) WO2017087778A1 (pt)
ZA (1) ZA201803530B (pt)

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US9499522B2 (en) 2013-03-15 2016-11-22 Blueprint Medicines Corporation Compositions useful for treating disorders related to kit
HUE039687T2 (hu) 2013-10-17 2019-01-28 Blueprint Medicines Corp Kompozíciók, amelyek alkalmazhatók KIT-tel kapcsolatos rendellenességek kezelésében való alkalmazásra
DK3395814T3 (da) 2013-10-25 2022-07-04 Blueprint Medicines Corp Hæmmere af fibroblastvækstfaktorreceptoren
US9695165B2 (en) 2014-01-15 2017-07-04 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
US10202365B2 (en) 2015-02-06 2019-02-12 Blueprint Medicines Corporation 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
BR112018001190A2 (pt) 2015-07-24 2018-09-11 Blueprint Medicines Corp composições úteis para tratar distúrbios relacionados a kit e pdfgr
JP6877407B2 (ja) 2015-08-26 2021-05-26 ブループリント メディシンズ コーポレイション Ｎｔｒｋ関連障害の治療に有用な化合物および組成物
MY194262A (en) 2015-11-02 2022-11-25 Blueprint Medicines Corp Inhibitors of ret
RU2018122089A (ru) 2015-11-19 2019-12-25 Блюпринт Медсинс Корпорейшн Соединения и композиции, подходящие для лечения расстройств, связанных с ntrk
WO2017161269A1 (en) 2016-03-17 2017-09-21 Blueprint Medicines Corporation Inhibitors of ret receptor tyrosine kinases
FI3442977T3 (fi) 2016-04-15 2023-09-26 Blueprint Medicines Corp Aktiviinireseptorin kaltaisen kinaasin estäjät
WO2018017983A1 (en) 2016-07-22 2018-01-25 Blueprint Medicines Corporation Compounds useful for treating disorders related to ret
US10035789B2 (en) 2016-07-27 2018-07-31 Blueprint Medicines Corporation Compounds useful for treating disorders related to RET
US11040979B2 (en) 2017-03-31 2021-06-22 Blueprint Medicines Corporation Substituted pyrrolo[1,2-b]pyridazines for treating disorders related to KIT and PDGFR
JP7278273B2 (ja) 2017-10-18 2023-05-19 ブループリント メディシンズ コーポレイション アクチビン受容体様キナーゼの阻害剤としての置換ピロロピリジン
BR112020020273A2 (pt) 2018-04-03 2021-04-06 Blueprint Medicines Corporation Inibidor de ret para uso no tratamento de câncer tendo uma alteração de ret
MA54092A (fr) 2018-10-30 2021-09-08 Kronos Bio Inc Composés, compositions et procédés de modulation de l'activité de cdk9
EP3942045A1 (en) 2019-03-21 2022-01-26 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
JP2022526438A (ja) 2019-04-12 2022-05-24 ブループリント メディシンズ コーポレイション （ｓ）－１－（４－フルオロフェニル）－１－（２－（４－（６－（１－メチル－１ｈ－ピラゾール－４－イル）ピロロ［２，１－ｆ］［１、２，４］トリアジン－４－イル）ピペラジニル）－ピリミジン－５－イル）エタン－１－アミンの結晶形態及び製造方法
JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
CN112979679B (zh) * 2019-12-13 2021-10-29 成都倍特药业股份有限公司 具有大环结构的含氟并杂环衍生物及其用途
CN112979654B (zh) * 2019-12-16 2024-03-19 赛诺哈勃药业（成都）有限公司 杂芳基稠环化合物、其制备方法及应用
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

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JP6877407B2 (ja) 2015-08-26 2021-05-26 ブループリント メディシンズ コーポレイション Ｎｔｒｋ関連障害の治療に有用な化合物および組成物
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RU2018122089A (ru) 2015-11-19 2019-12-25 Блюпринт Медсинс Корпорейшн Соединения и композиции, подходящие для лечения расстройств, связанных с ntrk
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Also Published As

Publication number Publication date
JP2019500328A (ja) 2019-01-10
ZA201803530B (en) 2021-08-25
RU2018122089A3 (pt) 2019-12-30
KR20180081790A (ko) 2018-07-17
PH12018501065A1 (en) 2019-01-28
EP3377497A1 (en) 2018-09-26
TWI733713B (zh) 2021-07-21
SG11201803920TA (en) 2018-06-28
US20170145018A1 (en) 2017-05-25
CN108431008A (zh) 2018-08-21
AR106756A1 (es) 2018-02-14
US10370379B2 (en) 2019-08-06
US11059827B2 (en) 2021-07-13
US20190382410A1 (en) 2019-12-19
TW201720826A (zh) 2017-06-16
IL259164A (en) 2018-06-28
RU2018122089A (ru) 2019-12-25
MX2018006195A (es) 2018-09-05
BR112018010024A8 (pt) 2019-02-26
AU2016355196A1 (en) 2018-06-21
WO2017087778A1 (en) 2017-05-26
SG10201912607SA (en) 2020-02-27
CA3005741A1 (en) 2017-05-26
HK1259453A1 (zh) 2019-11-29

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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
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