BR112018007982B1 - Composição, reação enzimática e método para preparar um copolímero de enxerto - Google Patents
Composição, reação enzimática e método para preparar um copolímero de enxerto Download PDFInfo
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- BR112018007982B1 BR112018007982B1 BR112018007982-0A BR112018007982A BR112018007982B1 BR 112018007982 B1 BR112018007982 B1 BR 112018007982B1 BR 112018007982 A BR112018007982 A BR 112018007982A BR 112018007982 B1 BR112018007982 B1 BR 112018007982B1
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- Brazil
- Prior art keywords
- dextran
- alpha
- glucan
- graft copolymer
- present application
- Prior art date
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- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/02—Dextran; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
- C12P19/08—Dextran
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- Chemical & Material Sciences (AREA)
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| HUE055838T2 (hu) | 2016-12-16 | 2021-12-28 | Procter & Gamble | Amfifil poliszacharid-származékok és azokat tartalmazó készítmények |
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| CA3061734A1 (en) | 2017-05-23 | 2018-11-29 | Kevin D. Nagy | Enzymatic production of alpha-1,3-glucan |
| JP2018198570A (ja) * | 2017-05-29 | 2018-12-20 | 国立大学法人 東京大学 | 櫛形構造のグルカンを含むゲル組成物 |
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| EP4467599A3 (en) | 2017-12-14 | 2025-04-23 | Nutrition & Biosciences USA 4, Inc. | Alpha-1,3-glucan graft copolymers |
| EP3740583A1 (en) | 2018-02-23 | 2020-11-25 | Danisco US Inc. | Synthesis of glucan comprising alpha-1,3 glycosidic linkages with phosphorylase enzymes |
| JP7576263B2 (ja) | 2018-06-20 | 2024-10-31 | デュポン・インダストリアル・バイオサイエンシーズ・ユーエスエイ・エルエルシー | 多糖誘導体及び同一物を含む組成物 |
| EP3810658A1 (en) | 2018-06-20 | 2021-04-28 | The Procter & Gamble Company | A product comprising polysaccharide derivatives |
| CN113574074B (zh) * | 2018-10-25 | 2023-03-21 | 营养与生物科学美国第四公司 | α-1,3-葡聚糖接枝共聚物 |
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| CN115052489B (zh) | 2019-08-16 | 2024-09-13 | 营养与生物科学美国第四公司 | 包含不溶性α-1,3-葡聚糖的基于面粉和粗粉的食品产品 |
| MX2022005441A (es) | 2019-11-06 | 2022-10-10 | Nutrition & Biosciences Usa 4 Inc | Alfa-1,3-glucano altamente cristalino. |
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| EP4165090A1 (en) | 2020-06-10 | 2023-04-19 | Nutrition & Biosciences USA 4, Inc. | Poly alpha-1,6-glucan derivatives and compositions comprising same |
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| EP4334363A1 (en) | 2021-05-04 | 2024-03-13 | Nutrition & Biosciences USA 4, Inc. | Compositions comprising insoluble alpha-glucan |
| EP4334364A1 (en) | 2021-05-04 | 2024-03-13 | Nutrition & Biosciences USA 4, Inc. | Compositions comprising oxidized insoluble alpha-glucan |
| JP2024525685A (ja) | 2021-07-13 | 2024-07-12 | ニュートリション・アンド・バイオサイエンシーズ・ユーエスエー・フォー，インコーポレイテッド | カチオン性グルカンエステル誘導体 |
| WO2023055902A1 (en) | 2021-09-30 | 2023-04-06 | Dupont Nutrition Biosciences Aps | Method for reducing sugar in food stuff |
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| WO2024129951A1 (en) | 2022-12-16 | 2024-06-20 | Nutrition & Biosciences USA 4, Inc. | Esterification of alpha-glucan comprising alpha-1,6 glycosidic linkages |
| US20240263162A1 (en) | 2023-02-01 | 2024-08-08 | The Procter & Gamble Company | Detergent compositions containing enzymes |
| CN120677237A (zh) | 2023-02-01 | 2025-09-19 | 丹尼斯科美国公司 | 枯草杆菌蛋白酶变体和使用方法 |
| AU2024242918A1 (en) | 2023-03-29 | 2025-09-18 | Danisco Us Inc. | Methods for modifying texture in foodstuff via preferably in situ produced alpha-glucan |
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| WO2025006691A2 (en) | 2023-06-30 | 2025-01-02 | Nutrition & Biosciences USA 4, Inc. | Porous alpha-1,3-glucan compositions |
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| WO2025198996A1 (en) | 2024-03-19 | 2025-09-25 | Danisco Us Inc. | Method for improving flavor in foodstuff |
| WO2025199079A1 (en) | 2024-03-20 | 2025-09-25 | Nutrition & Biosciences USA 4, Inc. | Esterification of alpha-glucan comprising alpha-1,6 glycosidic linkages |
Family Cites Families (25)
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| US5952205A (en) | 1998-02-06 | 1999-09-14 | Neose Technologies, Inc. | Process for processing sucrose into glucose and fructose |
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| NZ530638A (en) | 2001-07-20 | 2006-01-27 | Tno | Novel glucans and novel glucansucrases derived from lactic acid bacteria |
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| US7524645B2 (en) | 2004-12-14 | 2009-04-28 | Centre National De La Recherche Scientifique (Cnrs) | Fully active alternansucrases partially deleted in its carboxy-terminal and amino-terminal domains and mutants thereof |
| EP1679374A1 (en) | 2005-01-10 | 2006-07-12 | Bayer CropScience GmbH | Transformed plant expressing a mutansucrase and synthesizing a modified starch |
| PT2080775E (pt) | 2006-10-18 | 2015-10-20 | Toray Industries | Polímero de poliacrilonitrilo, processo para a produção do polímero, processo para a produção da fibra precursora para fibra de carbono, fibra de carbono, e processo para a produção da fibra de carbono |
| EP3115452B1 (en) * | 2007-04-26 | 2019-10-16 | Hayashibara Co., Ltd. | Branched alpha-glucan, alpha-glucosyltransferase which forms glucan, their preparation and uses |
| US20090046274A1 (en) | 2007-08-16 | 2009-02-19 | Mchugh Mark A | Light Scattering Methods and Systems Using Supercritical Fluid Solvents to Measure Polymer Molecular Weight and Molecular Weight Distribution |
| FR2937974B1 (fr) | 2008-10-30 | 2013-01-11 | Univ Bordeaux 1 | Copolymeres a blocs a base de polysaccharide et de polypeptide, les vesicules constituees de ces copolymeres et leur utilisation |
| MX2011011659A (es) | 2009-05-07 | 2012-02-28 | Tate & Lyle Ingredients France SAS | Composiciones y metodos para elaborar alfa-(1,6) oligodextranos ramificados en alfa-(1,2). |
| US8642757B2 (en) | 2011-09-09 | 2014-02-04 | E I Du Pont De Nemours And Company | High titer production of highly linear poly (α 1,3 glucan) |
| US9080195B2 (en) | 2011-09-09 | 2015-07-14 | E I Du Pont De Nemours And Company | High titer production of poly (α 1,3 glucan) |
| WO2013096502A1 (en) | 2011-12-19 | 2013-06-27 | E. I. Du Pont De Nemours And Company | INCREASED POLY (α 1, 3 GLUCAN) YIELD USING BORIC ACID |
| WO2013096511A1 (en) | 2011-12-19 | 2013-06-27 | E. I. Du Pont De Nemours And Company | Increased poly (alpha - 1, 3 - glucan) yield using tetraborate |
| CN102634033B (zh) | 2012-03-21 | 2015-12-16 | 东北师范大学 | 葡聚糖基两亲性嵌段共聚物制备方法 |
| CN104838010B (zh) | 2012-09-25 | 2018-07-06 | 纳幕尔杜邦公司 | 用于制备葡聚糖聚合物的葡糖基转移酶 |
| FR3007038B1 (fr) * | 2013-06-17 | 2016-02-26 | Agronomique Inst Nat Rech | Polypeptide ayant la capacite de former des branchements d'unites glucosyle en alpha-1,3 sur un accepteur |
| US9644190B2 (en) | 2014-02-06 | 2017-05-09 | The United States Of America, As Represented By The Secretary Of Agriculture | Modified glucansucrase and related methods |
| US20150232785A1 (en) | 2014-02-14 | 2015-08-20 | E I Du Pont De Nemours And Company | Polysaccharides for viscosity modification |
| WO2015123327A1 (en) | 2014-02-14 | 2015-08-20 | E. I. Du Pont De Nemours And Company | Glucosyltransferase enzymes for production of glucan polymers |
| CN107074985B (zh) | 2014-11-05 | 2020-07-24 | 纳幕尔杜邦公司 | 酶促聚合的凝胶化右旋糖酐 |
| WO2016105971A1 (en) | 2014-12-22 | 2016-06-30 | E. I. Du Pont De Nemours And Company | Polysaccharide compositions for absorbing aqueous liquid |
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