BR112018001900A2 - composições agonistas de trkb ou trkc e métodos para o tratamento de condições óticas - Google Patents

composições agonistas de trkb ou trkc e métodos para o tratamento de condições óticas

Info

Publication number
BR112018001900A2
BR112018001900A2 BR112018001900-3A BR112018001900A BR112018001900A2 BR 112018001900 A2 BR112018001900 A2 BR 112018001900A2 BR 112018001900 A BR112018001900 A BR 112018001900A BR 112018001900 A2 BR112018001900 A2 BR 112018001900A2
Authority
BR
Brazil
Prior art keywords
trkb
methods
optical conditions
trkc agonist
agonist compositions
Prior art date
Application number
BR112018001900-3A
Other languages
English (en)
Inventor
Uri Saragovi Horacio
Piu Fabrice
Foster Alan
Black Kristenann
Original Assignee
Otonomy, Inc.
Uri Saragovi Horacio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otonomy, Inc., Uri Saragovi Horacio filed Critical Otonomy, Inc.
Publication of BR112018001900A2 publication Critical patent/BR112018001900A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Psychology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR112018001900-3A 2015-07-28 2016-07-28 composições agonistas de trkb ou trkc e métodos para o tratamento de condições óticas BR112018001900A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562198065P 2015-07-28 2015-07-28
US62/198,065 2015-07-28
PCT/US2016/044574 WO2017019907A1 (en) 2015-07-28 2016-07-28 Trkb or trkc agonist compositions and methods for the treatment of otic conditions

Publications (1)

Publication Number Publication Date
BR112018001900A2 true BR112018001900A2 (pt) 2018-09-18

Family

ID=57885018

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018001900-3A BR112018001900A2 (pt) 2015-07-28 2016-07-28 composições agonistas de trkb ou trkc e métodos para o tratamento de condições óticas

Country Status (10)

Country Link
US (2) US20170029511A1 (pt)
EP (1) EP3328898B8 (pt)
JP (1) JP7023461B2 (pt)
KR (1) KR20180037994A (pt)
CN (1) CN108699160A (pt)
AU (1) AU2016298307A1 (pt)
BR (1) BR112018001900A2 (pt)
CA (1) CA2993645A1 (pt)
IL (1) IL257060A (pt)
WO (1) WO2017019907A1 (pt)

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CN114940713B (zh) * 2017-03-15 2024-04-30 清华大学 抗trkb抗体
EP3406259A1 (en) * 2017-05-24 2018-11-28 Dompé farmaceutici S.p.A. Neurotrophins for use in the treatment of hearing loss
US10793634B2 (en) 2017-06-09 2020-10-06 Boehringer Ingelheim International Gmbh Anti-TrkB antibodies
CN111372949A (zh) 2017-11-30 2020-07-03 瑞泽恩制药公司 抗trkb单克隆抗体及其使用方法
US11911416B2 (en) 2018-08-01 2024-02-27 University Of Iowa Research Foundation Compositions and methods to restore hearing loss and balance through embryonic ear transplant
US10561736B1 (en) 2019-01-09 2020-02-18 Spiral Therapeutics, Inc. Apoptosis inhibitor formulations for prevention of hearing loss
US20220226437A1 (en) * 2019-05-29 2022-07-21 Massachusetts Eye And Ear Infirmary Fibroblast growth factor 2 (FGF2) for Treatment of Human Sensorineural Hearing Loss
EP4093387A4 (en) * 2020-01-24 2024-04-24 Dompé farmaceutici S.p.A. GROWTH FACTOR FORMULATION FOR A CONDITION ASSOCIATED WITH AN OTIC EVENT
CN116133689A (zh) * 2020-07-07 2023-05-16 豪夫迈·罗氏有限公司 作为治疗性蛋白质制剂的稳定剂的替代表面活性剂
WO2023125485A1 (en) * 2021-12-28 2023-07-06 4B Technologies (Beijing) Co., Limited TrkB ANTIBODY AND APPLICATION THEREOF
WO2024040232A2 (en) * 2022-08-19 2024-02-22 Lankenau Institute For Medical Research Methods of treating conditions using anti-nmda receptor antibodies

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Also Published As

Publication number Publication date
WO2017019907A1 (en) 2017-02-02
CA2993645A1 (en) 2017-02-02
EP3328898B1 (en) 2024-03-06
CN108699160A (zh) 2018-10-23
EP3328898A4 (en) 2019-01-23
US20200190201A1 (en) 2020-06-18
JP7023461B2 (ja) 2022-02-22
EP3328898A1 (en) 2018-06-06
KR20180037994A (ko) 2018-04-13
EP3328898B8 (en) 2024-04-10
IL257060A (en) 2018-03-29
JP2018522016A (ja) 2018-08-09
AU2016298307A1 (en) 2018-02-15
US20170029511A1 (en) 2017-02-02

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements