BR112017026406A2 - formas sólidas de ácido (z)-4-(5-((3-benzil-4-oxo-2-tioxotiazolidin-5-ilideno)metil)furan-2-il)benzoico - Google Patents
formas sólidas de ácido (z)-4-(5-((3-benzil-4-oxo-2-tioxotiazolidin-5-ilideno)metil)furan-2-il)benzoicoInfo
- Publication number
- BR112017026406A2 BR112017026406A2 BR112017026406-4A BR112017026406A BR112017026406A2 BR 112017026406 A2 BR112017026406 A2 BR 112017026406A2 BR 112017026406 A BR112017026406 A BR 112017026406A BR 112017026406 A2 BR112017026406 A2 BR 112017026406A2
- Authority
- BR
- Brazil
- Prior art keywords
- thioxothiazolidin
- furan
- oxo
- benzyl
- methyl
- Prior art date
Links
- AEZGRQSLKVNPCI-UNOMPAQXSA-N 4-[5-[(z)-(3-benzyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1C(O1)=CC=C1\C=C/1C(=O)N(CC=2C=CC=CC=2)C(=S)S\1 AEZGRQSLKVNPCI-UNOMPAQXSA-N 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000006495 integrins Human genes 0.000 abstract 1
- 108010044426 integrins Proteins 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR122023025347-7A BR122023025347A2 (pt) | 2015-06-12 | 2016-06-10 | Sal de meglumina ou trometamina de um composto, formas cristalinas e formulações farmacêuticas dos mesmos e seus usos |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562175066P | 2015-06-12 | 2015-06-12 | |
| US62/175,066 | 2015-06-12 | ||
| US201662275655P | 2016-01-06 | 2016-01-06 | |
| US62/275,655 | 2016-01-06 | ||
| PCT/US2016/037067 WO2016201356A1 (en) | 2015-06-12 | 2016-06-10 | Solid forms of (z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017026406A2 true BR112017026406A2 (pt) | 2019-04-02 |
Family
ID=57504544
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017026406-4A BR112017026406A2 (pt) | 2015-06-12 | 2016-06-10 | formas sólidas de ácido (z)-4-(5-((3-benzil-4-oxo-2-tioxotiazolidin-5-ilideno)metil)furan-2-il)benzoico |
| BR122023025347-7A BR122023025347A2 (pt) | 2015-06-12 | 2016-06-10 | Sal de meglumina ou trometamina de um composto, formas cristalinas e formulações farmacêuticas dos mesmos e seus usos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122023025347-7A BR122023025347A2 (pt) | 2015-06-12 | 2016-06-10 | Sal de meglumina ou trometamina de um composto, formas cristalinas e formulações farmacêuticas dos mesmos e seus usos |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10723726B2 (https=) |
| EP (1) | EP3307722B1 (https=) |
| JP (1) | JP2018521121A (https=) |
| KR (1) | KR102663856B1 (https=) |
| CN (1) | CN107848991B (https=) |
| AU (2) | AU2016275125A1 (https=) |
| BR (2) | BR112017026406A2 (https=) |
| CA (2) | CA3221219A1 (https=) |
| ES (1) | ES2896674T3 (https=) |
| IL (1) | IL256237B (https=) |
| SG (1) | SG10201911442XA (https=) |
| WO (1) | WO2016201356A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016275125A1 (en) | 2015-06-12 | 2018-01-25 | Gb006, Inc. | Solid forms of (z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid |
| WO2018126072A1 (en) * | 2016-12-29 | 2018-07-05 | Adhaere Pharmaceuticals, Inc. | Heterocyclic integrin agonists |
| MX394899B (es) * | 2017-03-30 | 2025-03-24 | Merck Patent Gmbh | Forma solida de (s)-[2-cloro-4-fluoro-5-(7-morfolin-4-il-quinazolin-4-il)fenil]-(6-metoxi-piridazin-3-il)-metanol. |
| TWI687415B (zh) | 2017-08-17 | 2020-03-11 | 美商基利科學股份有限公司 | Hiv蛋白質膜抑制劑之固體形式 |
| CN120053445A (zh) | 2018-07-16 | 2025-05-30 | 吉利德科学公司 | 用于治疗hiv的衣壳抑制剂 |
| CN113166056B (zh) | 2018-11-28 | 2024-07-05 | 罗欣药业(上海)有限公司 | 一种雌激素受体下调剂的盐型、晶型及其制备方法 |
| WO2020236668A1 (en) | 2019-05-17 | 2020-11-26 | Gb006, Inc. | Leukadherin-1 alone or in combination for use in the treatment of cancer |
| WO2021061665A1 (en) * | 2019-09-23 | 2021-04-01 | Gb006, Inc. | Integrin agonist prodrugs |
| WO2021096988A1 (en) | 2019-11-12 | 2021-05-20 | Gb006, Inc. | Crystalline salt forms of (z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid |
| WO2023039170A1 (en) * | 2021-09-09 | 2023-03-16 | Musc Foundation For Research Development | Selective targeting of cd38 activity as an immunostimulatory and antitumor strategy |
| US20260062432A1 (en) * | 2022-09-02 | 2026-03-05 | Rexpharmtech Co., Ltd | Novel benfotiamine choline salt |
| WO2024081449A1 (en) * | 2022-10-14 | 2024-04-18 | Rush University Medical Center | Cd11b agonists for treatment of autoimmune disease |
| CN121197154A (zh) * | 2025-11-13 | 2025-12-26 | 首都医科大学附属北京天坛医院 | Mac-1激动剂在制备治疗和/或缓解脑出血药物中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040002526A1 (en) * | 2002-04-03 | 2004-01-01 | Cell Therapeutics, Inc. | Phospholipase D inhibitors and uses thereof |
| EP1654380A4 (en) | 2003-08-14 | 2009-09-09 | Insight Biopharmaceuticals Ltd | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR MODULATING HEPARANASE ACTIVATION AND USES THEREOF |
| TW200526638A (en) | 2003-10-22 | 2005-08-16 | Smithkline Beecham Corp | 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline |
| FI20041129A0 (fi) | 2004-08-30 | 2004-08-30 | Ctt Cancer Targeting Tech Oy | Tioksotiatsolidinoniyhdisteitä lääkkeinä käytettäviksi |
| US7718680B2 (en) * | 2004-09-23 | 2010-05-18 | Burnham Institute For Medical Research | Inhibition of lethal factor protease activity from anthrax toxin |
| ITMI20042475A1 (it) * | 2004-12-23 | 2005-03-23 | Cell Therapeutics Europe Srl | Uso di derivati tiazolidinonici come agenti terapeutici |
| WO2008005651A2 (en) | 2006-06-08 | 2008-01-10 | Decode Chemistry, Inc. | Cyclic carboxylic acid rhodanine derivatives for the treatment and prevention of tuberculosis |
| WO2008082537A2 (en) | 2006-12-19 | 2008-07-10 | The General Hospital Corporation | Compounds for modulating integrin cd11b/cd18 |
| WO2008091532A1 (en) * | 2007-01-19 | 2008-07-31 | Panacos Pharmaceuticals, Inc. | Salts of 3-o-(3',3'-dimethylsuccinyl)betulinic acid and solid state forms thereof |
| US9023876B2 (en) | 2010-07-08 | 2015-05-05 | Adhaere Pharmaceuticals, Inc. | Compounds and methods for regulating integrins |
| CN103159695B (zh) * | 2011-12-08 | 2015-08-12 | 首都师范大学 | 可抑制hiv复制并对耐药hiv病毒株有效的噻唑类化合物及其制备方法和用途 |
| WO2013159082A1 (en) | 2012-04-20 | 2013-10-24 | Adhaere Pharmaceuticals, Inc. | Compounds and methods for regulating integrins |
| AU2016275125A1 (en) | 2015-06-12 | 2018-01-25 | Gb006, Inc. | Solid forms of (z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid |
-
2016
- 2016-06-10 AU AU2016275125A patent/AU2016275125A1/en not_active Abandoned
- 2016-06-10 ES ES16808465T patent/ES2896674T3/es active Active
- 2016-06-10 WO PCT/US2016/037067 patent/WO2016201356A1/en not_active Ceased
- 2016-06-10 EP EP16808465.5A patent/EP3307722B1/en active Active
- 2016-06-10 CN CN201680041800.5A patent/CN107848991B/zh active Active
- 2016-06-10 KR KR1020177037752A patent/KR102663856B1/ko active Active
- 2016-06-10 BR BR112017026406-4A patent/BR112017026406A2/pt not_active Application Discontinuation
- 2016-06-10 CA CA3221219A patent/CA3221219A1/en active Pending
- 2016-06-10 US US15/735,560 patent/US10723726B2/en active Active
- 2016-06-10 SG SG10201911442XA patent/SG10201911442XA/en unknown
- 2016-06-10 BR BR122023025347-7A patent/BR122023025347A2/pt not_active Application Discontinuation
- 2016-06-10 CA CA2988584A patent/CA2988584C/en active Active
- 2016-06-10 JP JP2018516398A patent/JP2018521121A/ja active Pending
-
2017
- 2017-12-11 IL IL256237A patent/IL256237B/en unknown
-
2019
- 2019-11-05 US US16/675,097 patent/US11111239B2/en active Active
-
2020
- 2020-11-16 AU AU2020270457A patent/AU2020270457B2/en active Active
-
2022
- 2022-11-01 US US17/978,848 patent/US12227497B2/en active Active
-
2025
- 2025-01-09 US US19/015,307 patent/US20250353840A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018521121A (ja) | 2018-08-02 |
| US11111239B2 (en) | 2021-09-07 |
| CN107848991B (zh) | 2022-01-14 |
| IL256237A (en) | 2018-02-28 |
| NZ738836A (en) | 2024-03-22 |
| EP3307722B1 (en) | 2021-08-04 |
| SG10201911442XA (en) | 2020-02-27 |
| BR122023025347A2 (pt) | 2024-01-16 |
| US20250353840A1 (en) | 2025-11-20 |
| ES2896674T3 (es) | 2022-02-25 |
| EP3307722A4 (en) | 2018-12-05 |
| CA2988584C (en) | 2024-01-23 |
| CA3221219A1 (en) | 2016-12-15 |
| KR20180016443A (ko) | 2018-02-14 |
| AU2020270457A1 (en) | 2020-12-10 |
| CN107848991A (zh) | 2018-03-27 |
| IL256237B (en) | 2021-12-01 |
| AU2016275125A1 (en) | 2018-01-25 |
| US10723726B2 (en) | 2020-07-28 |
| CA2988584A1 (en) | 2016-12-15 |
| US20180354938A1 (en) | 2018-12-13 |
| AU2020270457B2 (en) | 2022-10-20 |
| US20230227443A1 (en) | 2023-07-20 |
| US20200317657A1 (en) | 2020-10-08 |
| US12227497B2 (en) | 2025-02-18 |
| WO2016201356A1 (en) | 2016-12-15 |
| KR102663856B1 (ko) | 2024-05-07 |
| EP3307722A1 (en) | 2018-04-18 |
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Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B25A | Requested transfer of rights approved |
Owner name: GB006, INC. (US) |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B154 | Notification of filing of divisional application [chapter 15.50 patent gazette] |
Free format text: O PEDIDO FOI DIVIDIDO NO BR122023025347-7 PROTOCOLO 870230106357 EM 01/12/2023 18:09. |
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| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
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| B12B | Appeal against refusal [chapter 12.2 patent gazette] |