BR112017020836A2 - método para fabricar material fibroso biodegradável contendo medicamento pela eletrofiação - Google Patents

método para fabricar material fibroso biodegradável contendo medicamento pela eletrofiação

Info

Publication number
BR112017020836A2
BR112017020836A2 BR112017020836-9A BR112017020836A BR112017020836A2 BR 112017020836 A2 BR112017020836 A2 BR 112017020836A2 BR 112017020836 A BR112017020836 A BR 112017020836A BR 112017020836 A2 BR112017020836 A2 BR 112017020836A2
Authority
BR
Brazil
Prior art keywords
drug
electrospinning
medicine
manufacturing
material containing
Prior art date
Application number
BR112017020836-9A
Other languages
English (en)
Japanese (ja)
Inventor
Nishikawa Yasutoshi
Makita Masashi
Osada Naoki
Original Assignee
Orthorebirth Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orthorebirth Co., Ltd. filed Critical Orthorebirth Co., Ltd.
Publication of BR112017020836A2 publication Critical patent/BR112017020836A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/0023—Electro-spinning characterised by the initial state of the material the material being a polymer melt
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
    • D01D5/0046—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion the fibre formed by coagulation, i.e. wet electro-spinning
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
    • D01D5/0076—Electro-spinning characterised by the electro-spinning apparatus characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D7/00—Collecting the newly-spun products
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F1/00—General methods for the manufacture of artificial filaments or the like
    • D01F1/02—Addition of substances to the spinning solution or to the melt
    • D01F1/10—Other agents for modifying properties
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/88—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polycondensation products as major constituent with other polymers or low-molecular-weight compounds
    • D01F6/92—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polycondensation products as major constituent with other polymers or low-molecular-weight compounds of polyesters
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
    • D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
    • D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
    • D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H3/00—Non-woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length
    • D04H3/005—Synthetic yarns or filaments
    • D04H3/009—Condensation or reaction polymers
    • D04H3/011—Polyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/58—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products
    • D01F6/62—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters
    • D01F6/625—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters derived from hydroxy-carboxylic acids, e.g. lactones
    • D—TEXTILES; PAPER
    • D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B2331/00—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products
    • D10B2331/04—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products polyesters, e.g. polyethylene terephthalate [PET]
    • D10B2331/041—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products polyesters, e.g. polyethylene terephthalate [PET] derived from hydroxy-carboxylic acids, e.g. lactones
    • D—TEXTILES; PAPER
    • D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B2509/00—Medical; Hygiene

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Textile Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
  • Artificial Filaments (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

a presente invenção trata o problema de fornecer um material de formulação de medicamento com o qual a liberação prolongada localizada de um medicamento em qualquer local no corpo é possível, e que tem boa bioabsorção e é absorvido e decomposto pelo corpo depois da liberação prolongada do medicamento. um material de formulação de medicamento que tem um efeito de liberação prolongada extremamente alta, e que soluciona o problema precedente, foi desenvolvido com êxito dissolvendo-se uma resina biodegradável e um medicamento em um solvente para preparar uma solução de fiação, e fiar fibras a partir da solução de fiação pela eletrofiação.
BR112017020836-9A 2015-03-31 2016-03-31 método para fabricar material fibroso biodegradável contendo medicamento pela eletrofiação BR112017020836A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562140722P 2015-03-31 2015-03-31
US62/140,722 2015-03-31
PCT/JP2016/060670 WO2016159240A1 (ja) 2015-03-31 2016-03-31 エレクトロスピニングを用いた、薬剤を含有する生分解性繊維素材の製造方法

Publications (1)

Publication Number Publication Date
BR112017020836A2 true BR112017020836A2 (pt) 2018-07-03

Family

ID=57006916

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017020836-9A BR112017020836A2 (pt) 2015-03-31 2016-03-31 método para fabricar material fibroso biodegradável contendo medicamento pela eletrofiação

Country Status (10)

Country Link
US (1) US20180021485A1 (pt)
EP (1) EP3278791A4 (pt)
JP (1) JPWO2016159240A1 (pt)
CN (1) CN107530276A (pt)
BR (1) BR112017020836A2 (pt)
HK (1) HK1249411A1 (pt)
MX (1) MX2017012400A (pt)
SG (1) SG11201707988YA (pt)
WO (1) WO2016159240A1 (pt)
ZA (1) ZA201706943B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017257943B2 (en) * 2016-04-28 2020-04-30 National University Corporation Nagoya Institute Of Technology Method for manufacturing bone-regeneration material comprising biodegradable fibers by using electrospinning method
JP6912797B2 (ja) * 2017-02-10 2021-08-04 国立大学法人 鹿児島大学 多孔質構造体製造方法及び多孔質構造体製造装置
JP7228848B2 (ja) * 2018-02-22 2023-02-27 国立大学法人 名古屋工業大学 エレクトロスピニング法を用いて製造した生分解性繊維材料を綿状に回収する方法、及びその方法を用いて製造された綿状の骨再生用材料
WO2019168000A1 (ja) * 2018-02-27 2019-09-06 国立大学法人 琉球大学 コラゲナーゲを用いないで脂肪組織から脂肪由来幹細胞を分離抽出培養するための方法、及び脂肪由来幹細胞分離抽出用キット
US20210213163A1 (en) * 2018-05-17 2021-07-15 Meiji University Production method for bone-regeneration material imparted with antimicrobial properties using inositol phosphate, and antimicrobial bone-regeneration material produced by said production method
WO2020002413A1 (en) * 2018-06-27 2020-01-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Multilayer patch for postoperative drug administration
IL279785B1 (en) * 2018-07-09 2024-04-01 Nat Inst Materials Science Non-woven fabric, method for its production, and compound for electrospinning
US20220041970A1 (en) * 2018-09-14 2022-02-10 Orthorebirth Co. Ltd. Cell culture substrate made of nonwoven fabric manufactured using electrospinning and method of manufacturing the same
CN109908107B (zh) * 2019-02-27 2022-07-08 广东省医疗器械研究所 一种负载抗菌药物串珠状纳米纤维膜及其制备方法
US11779683B2 (en) 2019-04-08 2023-10-10 Loubert S. Suddaby Extended release immunomodulatory implant to facilitate bone morphogenesis
US11369473B2 (en) 2019-04-08 2022-06-28 Loubert S. Suddaby Extended release immunomodulatory implant to facilitate bone morphogenesis
JP6639035B1 (ja) * 2019-10-04 2020-02-05 Ｏｒｔｈｏｒｅｂｉｒｔｈ株式会社 生分解性繊維からなる不織布を用いて作製された細胞培養基材及びその製造方法
KR102348997B1 (ko) * 2020-11-03 2022-01-07 성균관대학교산학협력단 초음파 선택적 반응 시한성 나노복합소재 기반 마찰전기 발전소자 및 이를 이용한 신경 자극 치료 장치

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2396640A1 (en) * 2000-01-28 2001-08-02 Smithkline Beecham Corporation Electrospun pharmaceutical compositions
US20080220054A1 (en) * 2006-10-13 2008-09-11 Shastri V Prasad Modulation of drug release rate from electrospun fibers
US20090304771A1 (en) * 2008-04-03 2009-12-10 Drexel University Local Delivery System for the Chemotherapeutic Drug Paclitaxel
JP2012161363A (ja) * 2011-02-03 2012-08-30 Yahashi Kogyo Kk ケイ素及びカルシウム徐放性綿状物及びその製造方法
US20110038936A1 (en) * 2009-08-17 2011-02-17 Kimberly Ann Griswold System and method for electrospun drug loaded biodegradable chemotherapy applications
US20150037375A1 (en) * 2011-07-19 2015-02-05 Trustees Of Boston University Et Al Doping agents and polymeric compositions thereof for controlled drug delivery
CN203235057U (zh) * 2012-01-13 2013-10-16 株式会社奥梭瑞贝斯 用于填充骨缺损的纤维填料
WO2013124869A2 (en) * 2012-02-21 2013-08-29 Amrita Vishwa Vidyapeetham University The art, method,manner process and system of fibrous bio-degradable polymeric wafers for the local delivery of therapeutic agents in combinations
JP6039076B2 (ja) * 2013-07-09 2016-12-07 国立大学法人 名古屋工業大学 骨欠損部充填材料、及びその製造方法

Also Published As

Publication number Publication date
ZA201706943B (en) 2018-12-19
EP3278791A4 (en) 2018-10-24
HK1249411A1 (zh) 2018-11-02
CN107530276A (zh) 2018-01-02
JPWO2016159240A1 (ja) 2018-02-01
EP3278791A1 (en) 2018-02-07
US20180021485A1 (en) 2018-01-25
MX2017012400A (es) 2018-01-26
SG11201707988YA (en) 2017-10-30
WO2016159240A1 (ja) 2016-10-06

Similar Documents

Publication Publication Date Title
BR112017020836A2 (pt) método para fabricar material fibroso biodegradável contendo medicamento pela eletrofiação
BR112016028530A2 (pt) acionador de agulha circular
BR112015022985A2 (pt) Microesferas de buprenorfina de carga de fármaco alta e método para produção das mesmas
BR112018003845A2 (pt) auxiliares cirúrgicos com medicamentos afetados por materiais ativadores
BR112012033661A2 (pt) dispositivo de segurança para uma seringa preenchida e didpositivo de injeção
BR112012033634A2 (pt) blindagem de agulha para um dispositivo de segurança, dispositivo de segurança e dispositivo de injeção
BR112017006692A2 (pt) método de tratamento de uma formação subterrânea, sistema, resina endurecida autorregenerante, composição para o tratamento de uma formação, e, método de preparo de uma composição.
BR112015001898A2 (pt) sistema para identificar artefatos de movimentação; e método para identificar artefatos de movimentação
BR112018010671A2 (pt) dispositivos e métodos de distribuição de fármaco com mudança de forma
BR112012012210A2 (pt) polímeros á base de ciclodextrina para distribuição terapêutica
BR112016029690A2 (pt) material de interface térmica, e componente eletrônico
BR112016002180A2 (pt) composição amaciante de tecido, método para tratamento de tecido e uso de uma composição
BR112017005801A2 (pt) anticorpo capaz de neutralizar a substância tendo atividade alternativa para função de fator de coagulação viii (fviii)
CO2018007278A2 (es) Derivados de ácido aminobenzoico metaazacíclico como antagonistas de la integrina pan
BR112015017251A2 (pt) composições farmacêuticas compreendendo doadores de nitroxil
BR112015021958A2 (pt) polióis poliméricos à base de polióis de óleos naturais
BR112012023912A2 (pt) produto de artigos de confeitaria contendo componentes ativos e/ou reativos e métodos de produção do mesmo
BR112017008066A2 (pt) composição de polipropileno, processo para produção da composição de polipropileno, e, espuma extrusada.
EA201890436A1 (ru) Жидкая полимерная система доставки для длительного введения лекарственных средств
BR112015016079A2 (pt) método e dispositivo de atualização de sistema
BR112015006391A2 (pt) método para exibição da lista de dispositivos sem fio, método de difusão do dispositivo sem fio, dispositivo para exibição do dispositivo sem fio e dispositivo sem fio
BR112015011572A2 (pt) sistema para gerar uma imagem-chave a partir de uma imagem médica, estação de trabalho ou aparelho de imageamento, método para gerar uma imagem-chave a partir de uma imagem médica e produto de programa de computador
BR112014029370A2 (pt) atribuição de endereços a dispositivos em interconexão
NI201900046A (es) Formulación de complejo farmacéutica que comprende amlodipina, losartán y clortalidona.
BR112018001978A2 (pt) composição farmacêutica compreendendo fibras obtidas de forma eletro-hidrodinâ¬mica, composição com tempo de permanência melhorado sobre o local de aplicação

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]