BR112017020769A2 - antibody or binding fragment, sequence no: 3 or sequence no: 7, antibody-drug conjugate (adc), pharmaceutical composition, process for producing the pharmaceutical composition, kit for diagnosing an individual suffering from a neurodegenerative disorder, method to diagnose an individual suffering from a neurodegenerative disorder, use of antibody or binding fragment, ex vivo use of a t14 peptide, method of identifying a candidate agent, method of identifying an agent, method of identifying a modulating agent - Google Patents

antibody or binding fragment, sequence no: 3 or sequence no: 7, antibody-drug conjugate (adc), pharmaceutical composition, process for producing the pharmaceutical composition, kit for diagnosing an individual suffering from a neurodegenerative disorder, method to diagnose an individual suffering from a neurodegenerative disorder, use of antibody or binding fragment, ex vivo use of a t14 peptide, method of identifying a candidate agent, method of identifying an agent, method of identifying a modulating agent

Info

Publication number
BR112017020769A2
BR112017020769A2 BR112017020769-9A BR112017020769A BR112017020769A2 BR 112017020769 A2 BR112017020769 A2 BR 112017020769A2 BR 112017020769 A BR112017020769 A BR 112017020769A BR 112017020769 A2 BR112017020769 A2 BR 112017020769A2
Authority
BR
Brazil
Prior art keywords
antibody
antigen
binding fragment
seq
fragment
Prior art date
Application number
BR112017020769-9A
Other languages
English (en)
Portuguese (pt)
Inventor
Greenfield Susan
Garcia-Rates Sara
Morrill Paul
Original Assignee
Neuro-Bio Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuro-Bio Ltd filed Critical Neuro-Bio Ltd
Publication of BR112017020769A2 publication Critical patent/BR112017020769A2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Psychology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
BR112017020769-9A 2015-03-27 2016-03-23 antibody or binding fragment, sequence no: 3 or sequence no: 7, antibody-drug conjugate (adc), pharmaceutical composition, process for producing the pharmaceutical composition, kit for diagnosing an individual suffering from a neurodegenerative disorder, method to diagnose an individual suffering from a neurodegenerative disorder, use of antibody or binding fragment, ex vivo use of a t14 peptide, method of identifying a candidate agent, method of identifying an agent, method of identifying a modulating agent BR112017020769A2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1505239.2A GB201505239D0 (en) 2015-03-27 2015-03-27 Antibody
GB1505239.2 2015-03-27
GB1600871.6 2016-01-18
GB1600871.6A GB2541477A (en) 2015-03-27 2016-01-18 Antibody
PCT/GB2016/050804 WO2016156803A1 (en) 2015-03-27 2016-03-23 Antibody that recognises the t14 peptide of ache

Publications (1)

Publication Number Publication Date
BR112017020769A2 true BR112017020769A2 (en) 2018-06-26

Family

ID=53178191

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017020769-9A BR112017020769A2 (en) 2015-03-27 2016-03-23 antibody or binding fragment, sequence no: 3 or sequence no: 7, antibody-drug conjugate (adc), pharmaceutical composition, process for producing the pharmaceutical composition, kit for diagnosing an individual suffering from a neurodegenerative disorder, method to diagnose an individual suffering from a neurodegenerative disorder, use of antibody or binding fragment, ex vivo use of a t14 peptide, method of identifying a candidate agent, method of identifying an agent, method of identifying a modulating agent

Country Status (13)

Country Link
US (1) US10954306B2 (https=)
EP (1) EP3274371B1 (https=)
JP (1) JP7327897B2 (https=)
KR (1) KR102626626B1 (https=)
CN (1) CN107531796A (https=)
AU (1) AU2016240020B2 (https=)
BR (1) BR112017020769A2 (https=)
CA (1) CA2979972A1 (https=)
ES (1) ES2952723T3 (https=)
GB (2) GB201505239D0 (https=)
MX (1) MX392158B (https=)
RU (1) RU2729491C2 (https=)
WO (1) WO2016156803A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2539161A (en) * 2014-11-26 2016-12-14 Neuro-Bio Ltd Neurodegenerative disorders
GB2546773B (en) * 2016-01-28 2020-06-17 Neuro Bio Ltd Cancer
GB201705044D0 (en) * 2017-03-29 2017-05-10 Neuro-Bio Ltd Biomarker
AU2018308088B2 (en) 2017-07-25 2025-05-29 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
AU2020214796A1 (en) 2019-01-30 2021-07-29 Truebinding, Inc. Anti-Gal3 antibodies and uses thereof
WO2021242776A2 (en) 2020-05-26 2021-12-02 Truebinding, Inc. Methods of treating inflammatory diseases by blocking galectin-3
GB202112831D0 (en) * 2021-09-09 2021-10-27 Neuro Bio Ltd Biomarker
GB202113941D0 (en) 2021-09-29 2021-11-10 Neuro Bio Ltd Skin biomarker
CN120187864A (zh) 2022-09-08 2025-06-20 神经生物有限公司 使用t14肽诊断阿尔茨海默症的侧向流装置
GB202308779D0 (en) * 2023-06-13 2023-07-26 Neuro Bio Ltd Aptamer
GB202308799D0 (en) 2023-06-13 2023-07-26 Neuro Bio Ltd Neurodegenerative disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606040D0 (en) * 1996-03-22 1996-05-22 Isis Innovation Active peptide
EP1269201A1 (en) 2000-03-29 2003-01-02 Synaptica Limited Alpha 7 nicotinic receptor screening assays
GB0028578D0 (en) * 2000-11-23 2001-01-10 Synaptica Ltd Screening assays
GB0502068D0 (en) * 2005-02-01 2005-03-09 King S College London Screening method
JP5186372B2 (ja) * 2005-08-16 2013-04-17 ジェネンテック, インコーポレイテッド 細胞/組織においてgalnac−t14発現を試験することによるapo2l/trailに対するアポトーシス感受性
GB0708646D0 (en) * 2007-05-04 2007-06-13 Enkephala Ltd Biologically active C-terminal fragment of acetylcholinesterase
EP2203746B1 (en) * 2007-09-24 2013-03-06 Technion Research & Development Foundation Ltd. T cell subpopulations capable of treating cancer
CN101530162B (zh) * 2008-03-10 2011-11-23 北京大北农科技集团股份有限公司 一种新型蛋白饲料添加剂的制备方法

Also Published As

Publication number Publication date
GB201505239D0 (en) 2015-05-13
CN107531796A (zh) 2018-01-02
US20180051094A1 (en) 2018-02-22
US10954306B2 (en) 2021-03-23
EP3274371B1 (en) 2023-06-07
AU2016240020A1 (en) 2017-11-02
CA2979972A1 (en) 2016-10-06
ES2952723T3 (es) 2023-11-03
JP7327897B2 (ja) 2023-08-16
WO2016156803A1 (en) 2016-10-06
MX392158B (es) 2025-03-21
AU2016240020B2 (en) 2022-02-17
KR102626626B1 (ko) 2024-01-17
GB201600871D0 (en) 2016-03-02
RU2729491C2 (ru) 2020-08-07
GB2541477A (en) 2017-02-22
MX2017012397A (es) 2018-01-26
RU2017133649A3 (https=) 2020-02-17
JP2018516849A (ja) 2018-06-28
EP3274371A1 (en) 2018-01-31
RU2017133649A (ru) 2019-04-29
KR20170138414A (ko) 2017-12-15

Similar Documents

Publication Publication Date Title
US10954306B2 (en) Antibody that recognises the T14 peptide of AChE
US11739140B2 (en) Antibodies specific for hyperphosphorylated tau and methods of use thereof
JP7244600B2 (ja) 過リン酸化タウに特異的な抗体およびその使用方法
KR102786111B1 (ko) 고급 당화 최종 산물(age)에 대한 항체를 사용하여 암을 치료하고, 전이성 암 세포를 사멸시키고, 암 전이를 예방하기 위한 방법 및 조성물
AU2011267089B2 (en) S100A4 antibodies and therapeutic uses thereof
JP2016104727A (ja) タウオリゴマーに結合する抗体
WO2018127519A1 (en) Antibodies specific for hyperphosphorylated tau for the treatment of ocular diseases
CA2990555C (en) Antibodies specific for hyperphosphorylated tau and methods of use thereof
EA039569B1 (ru) Антитела, специфичные к гиперфосфорилированному тау-белку, и способы их применения
OA18779A (en) Antibodies Specific for Hyperphosphorylated Tau and Methods of Use Thereof.

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 3A. ANUIDADE.

B08G Application fees: restoration [chapter 8.7 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.