BR112017018060A2 - formulação de insulina, dose de unidade, e, método de tratar um indivíduo com diabetes melito. - Google Patents

formulação de insulina, dose de unidade, e, método de tratar um indivíduo com diabetes melito.

Info

Publication number
BR112017018060A2
BR112017018060A2 BR112017018060A BR112017018060A BR112017018060A2 BR 112017018060 A2 BR112017018060 A2 BR 112017018060A2 BR 112017018060 A BR112017018060 A BR 112017018060A BR 112017018060 A BR112017018060 A BR 112017018060A BR 112017018060 A2 BR112017018060 A2 BR 112017018060A2
Authority
BR
Brazil
Prior art keywords
treating
individual
unit dose
diabetes mellitus
insulin formulation
Prior art date
Application number
BR112017018060A
Other languages
English (en)
Inventor
Bueche Blaine
S Patton John
Sander Matthew
Kuo Mei-Chang
Original Assignee
Dance Biopharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dance Biopharm Inc filed Critical Dance Biopharm Inc
Publication of BR112017018060A2 publication Critical patent/BR112017018060A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

formulações líquidas de insulina contendo insulina física e quimicamente estável, mas não contendo conservantes ou estabilizantes são providas. as formulações também não possuem tensoativos. as formulações são úteis para vários modelos de dispensação incluindo a dispensação pulmonar.
BR112017018060A 2015-02-25 2015-12-21 formulação de insulina, dose de unidade, e, método de tratar um indivíduo com diabetes melito. BR112017018060A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562120573P 2015-02-25 2015-02-25
PCT/US2015/067129 WO2016137569A1 (en) 2015-02-25 2015-12-21 Liquid insulin formulations and methods relating thereto

Publications (1)

Publication Number Publication Date
BR112017018060A2 true BR112017018060A2 (pt) 2018-04-10

Family

ID=56689716

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017018060A BR112017018060A2 (pt) 2015-02-25 2015-12-21 formulação de insulina, dose de unidade, e, método de tratar um indivíduo com diabetes melito.

Country Status (7)

Country Link
US (2) US20160243199A1 (pt)
EP (1) EP3261648B1 (pt)
CN (1) CN107530372A (pt)
BR (1) BR112017018060A2 (pt)
CA (1) CA3011902C (pt)
HK (1) HK1245116A1 (pt)
WO (1) WO2016137569A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10842951B2 (en) 2010-01-12 2020-11-24 Aerami Therapeutics, Inc. Liquid insulin formulations and methods relating thereto
US9180261B2 (en) 2010-01-12 2015-11-10 Dance Biopharm Inc. Preservative free insulin formulations and systems and methods for aerosolizing
BR112017018060A2 (pt) 2015-02-25 2018-04-10 Dance Biopharm Inc formulação de insulina, dose de unidade, e, método de tratar um indivíduo com diabetes melito.

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4564129A (en) 1983-01-27 1986-01-14 Hoechst-Roussel Pharmaceuticals Inc. Dosage dispensing unit
US5152456A (en) 1989-12-12 1992-10-06 Bespak, Plc Dispensing apparatus having a perforate outlet member and a vibrating device
US6629646B1 (en) 1991-04-24 2003-10-07 Aerogen, Inc. Droplet ejector with oscillating tapered aperture
US5164740A (en) 1991-04-24 1992-11-17 Yehuda Ivri High frequency printing mechanism
US7628339B2 (en) 1991-04-24 2009-12-08 Novartis Pharma Ag Systems and methods for controlling fluid feed to an aerosol generator
US5938117A (en) 1991-04-24 1999-08-17 Aerogen, Inc. Methods and apparatus for dispensing liquids as an atomized spray
US6540154B1 (en) 1991-04-24 2003-04-01 Aerogen, Inc. Systems and methods for controlling fluid feed to an aerosol generator
US6131567A (en) 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US6024090A (en) 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US5915378A (en) 1993-01-29 1999-06-29 Aradigm Corporation Creating an aerosolized formulation of insulin
EP1462096B1 (en) 1994-03-07 2008-12-10 Nektar Therapeutics Methods and compositions for pulmonary delivery of insulin
US6014970A (en) 1998-06-11 2000-01-18 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US6205999B1 (en) 1995-04-05 2001-03-27 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US6085740A (en) 1996-02-21 2000-07-11 Aerogen, Inc. Liquid dispensing apparatus and methods
US5586550A (en) 1995-08-31 1996-12-24 Fluid Propulsion Technologies, Inc. Apparatus and methods for the delivery of therapeutic liquids to the respiratory system
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US6427682B1 (en) 1995-04-05 2002-08-06 Aerogen, Inc. Methods and apparatus for aerosolizing a substance
US20060239930A1 (en) 1997-08-04 2006-10-26 Herbert Lamche Process for nebulizing aqueous compositions containing highly concentrated insulin
EP1044016B1 (en) * 1998-01-09 2005-03-16 Novo Nordisk A/S Stabilised insulin compositions
US6440929B1 (en) 1998-07-27 2002-08-27 Emisphere Technologies, Inc. Pulmonary delivery of active agents
US6211144B1 (en) 1998-10-16 2001-04-03 Novo Nordisk A/S Stable concentrated insulin preparations for pulmonary delivery
US6635617B1 (en) * 1998-10-16 2003-10-21 Novo Nordisk A/S Insulin preparations for pulmonary delivery containing menthol
DE69914934T2 (de) * 1998-11-18 2005-01-05 Novo Nordisk A/S Stabile, wässrige insulin-präparate ohne phenol und cresol
US6489292B1 (en) 1998-11-18 2002-12-03 Novo Nordisk A/S Stable aqueous insulin preparations without phenol and cresol
US6312665B1 (en) 1998-12-21 2001-11-06 Generex Pharmaceuticals Incorporated Aerosol formulations for buccal and pulmonary application
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
WO2001052937A1 (en) * 2000-01-24 2001-07-26 Medtronic Minimed, Inc. Mixed buffer system for stabilizing polypeptide formulations
US6948491B2 (en) 2001-03-20 2005-09-27 Aerogen, Inc. Convertible fluid feed system with comformable reservoir and methods
US7100600B2 (en) 2001-03-20 2006-09-05 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
JP4147234B2 (ja) 2004-09-27 2008-09-10 キヤノン株式会社 吐出用液体、吐出方法、カートリッジ及び吐出装置
CN2461580Y (zh) 2001-02-09 2001-11-28 鲁崇恭 超声波雾化胰岛素吸入装置
US7225807B2 (en) 2001-03-15 2007-06-05 Creare Incorporated Systems and methods for aerosol delivery of agents
US6732944B2 (en) 2001-05-02 2004-05-11 Aerogen, Inc. Base isolated nebulizing device and methods
US20030068361A1 (en) 2001-10-09 2003-04-10 Rimona Margalit Liposome-encapsulated insulin formulations
AU2003236201A1 (en) 2002-05-07 2003-11-11 Novo Nordisk A/S Soluble formulations comprising monomeric insulin and acylated insulin
US20040045546A1 (en) 2002-09-05 2004-03-11 Peirce Management, Llc Pharmaceutical delivery system for oral inhalation through nebulization consisting of inert substrate impregnated with substance (S) to be solubilized or suspended prior to use
US7712466B2 (en) 2004-02-20 2010-05-11 Pneumoflex Systems, Llc Intra-oral nebulizer
WO2006082588A2 (en) 2005-02-07 2006-08-10 Pharmalight Inc. Method and device for ophthalmic administration of active pharmaceutical ingredients
US20100210506A1 (en) 2005-10-20 2010-08-19 Mdrna, Inc. Intranasal administration of rapid acting insulin
ATE519780T1 (de) * 2005-12-28 2011-08-15 Novo Nordisk As Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
WO2007104738A2 (en) 2006-03-13 2007-09-20 Novo Nordisk A/S Acylated single chain insulin
GB0610666D0 (en) 2006-05-30 2006-07-05 Glaxo Group Ltd Fluid dispenser
EP2514412A1 (en) * 2007-04-30 2012-10-24 Novo Nordisk A/S Highly Concentrated Insulin Solutions and Compositions
MX2010003935A (es) 2007-10-12 2010-09-24 Map Pharmaceuticals Inc Suministro de farmaco por inhalacion.
WO2009111612A1 (en) 2008-03-07 2009-09-11 Novartis Ag Aerosolization device
TWI394580B (zh) * 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
US9163883B2 (en) 2009-03-06 2015-10-20 Kevlin Thermal Technologies, Inc. Flexible thermal ground plane and manufacturing the same
US9180261B2 (en) 2010-01-12 2015-11-10 Dance Biopharm Inc. Preservative free insulin formulations and systems and methods for aerosolizing
US20130269684A1 (en) 2012-04-16 2013-10-17 Dance Pharmaceuticals, Inc. Methods and systems for supplying aerosolization devices with liquid medicaments
EP2691991A1 (en) * 2011-03-31 2014-02-05 Dow Corning Corporation Method of forming a photovoltaic cell module with a cell press
US20130269694A1 (en) 2012-04-16 2013-10-17 Dance Pharmaceuticals, Inc. Inhaler controlled by mobile device
AR094821A1 (es) 2012-07-25 2015-09-02 Hanmi Pharm Ind Co Ltd Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada
AR091902A1 (es) * 2012-07-25 2015-03-11 Hanmi Pharm Ind Co Ltd Formulacion liquida de un conjugado de insulina de accion prolongada
US10610651B2 (en) 2014-06-09 2020-04-07 Aerami Therapeutics, Inc. Self-puncturing liquid drug cartridges and associated dispenser
US10857313B2 (en) 2014-07-01 2020-12-08 Aerami Therapeutics, Inc. Liquid nebulization systems and methods
US10471222B2 (en) 2014-07-01 2019-11-12 Dance Biopharm Inc. Aerosolization system with flow restrictor and feedback device
BR112017018060A2 (pt) 2015-02-25 2018-04-10 Dance Biopharm Inc formulação de insulina, dose de unidade, e, método de tratar um indivíduo com diabetes melito.

Also Published As

Publication number Publication date
CA3011902C (en) 2023-08-15
EP3261648B1 (en) 2023-12-06
WO2016137569A1 (en) 2016-09-01
EP3261648A4 (en) 2018-10-24
EP3261648A1 (en) 2018-01-03
US20190160153A1 (en) 2019-05-30
CA3011902A1 (en) 2016-09-01
HK1245116A1 (zh) 2018-08-24
US20160243199A1 (en) 2016-08-25
US11096990B2 (en) 2021-08-24
CN107530372A (zh) 2018-01-02

Similar Documents

Publication Publication Date Title
WO2015106269A3 (en) Rapid action insulin formulations and pharmaceutical delivery systems
BR112019000195A2 (pt) composições e métodos relacionados a sistemas celulares terapêuticos que expressam rna exógeno
MX2016015179A (es) Una formulación líquida que comprende nicotina para administracion en aerosol.
EP3165227A4 (en) Composition for treating or preventing metabolic disease, containing, as active ingredient, extracellular vesicles derived from akkermansia muciniphila bacteria
CL2015003199A1 (es) Peptidos terapeuticos
BR112015009189A2 (pt) conjunto de potência para um autoinjetor e autoinjetor que contém o mesmo
EP3199036A4 (en) Composition, containing tyndallized lactobacillus dead cells as active ingredient, for skin moisturizing or wrinkle improvement
IL240949B (en) Aqueous pharmaceutical formulation for use in the treatment of type 1 or type 2 juvenile diabetes
BR112016006171A2 (pt) formulações de espuma e dispositivo para sua entrega
CL2016000026A1 (es) Nuevos derivados de azabencimidazol
EP3034082A4 (en) Pharmaceutical composition for treating or preventing neuropsychitric disease, containing flavone-6-c-glucose derivatives as active ingredients
CL2013003649A1 (es) Composición de concentrado de herbicida emulsionable que comprende 25-225 g/l de ácido ariloxifenoxipropiónico, 600-950 g/l de un adyuvante integrado no derivado del petróleo, y 10-150 g/l de un agente tensoactivo; método de control de vegetación indeseable en ambiente acuático, tal como un arrozal o un campo de arroz.
CL2014003148A1 (es) Composición farmacéutica acuosa que contiene un agente terapéutico biológico y guanidina o un derivado de la guanidina y una inyección que incluye la composición.
EP3138834A4 (en) Cyclohexene derivative, preparation method therefor, and pharmaceutical composition for preventing or treating metabolic diseases, containing same as active ingredient
DK3232780T3 (da) Vandige adjuvans-sammensætninger, der indeholder elektrolyt, sammensætninger, som indeholder et aktivt stof, og anvendelse deraf
BR112017018060A2 (pt) formulação de insulina, dose de unidade, e, método de tratar um indivíduo com diabetes melito.
WO2013060707A3 (de) Kosmetische mittel enthaltend oxytocin und riechstoffe
EP3352750A4 (en) Cyclohexene derivative, preparation method thereof, and pharmaceutical composition for preventing or treating metabolic disease comprising the same as active ingredient
EP3272332A4 (en) Phytoncide moisturizing liquid composition, hydrogen-generating skin care spray device comprising same, and method for preparing same
WO2015164387A3 (en) Systems, methods, and apparatus for providing machine-to-machine and consumer-to-machine interaction application platforms
MX2016000136A (es) Mezclas conservantes sinergicas.
CL2018001104A1 (es) Composición para el cuidado de la piel y procedimiento asociado.
WO2016030899A8 (en) Methods of treating amyotrophic lateral scleroses
SG11201901617PA (en) Azole compound ophthalmic preparation
EA201892157A1 (ru) Фосфаплатиновые жидкие составы

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]