BR112017003010A2 - (2s)-3-[(3s,4s)-3-[(1r)-1-hidroxietil]-4-(4-metoxi-3-{[1-(5-metilpiridin-2-il)azetidin-3-il]oxi}fenil)-3-metilpirrolidin-1-il]-3-oxopropano-1,2-diol cristalino - Google Patents

(2s)-3-[(3s,4s)-3-[(1r)-1-hidroxietil]-4-(4-metoxi-3-{[1-(5-metilpiridin-2-il)azetidin-3-il]oxi}fenil)-3-metilpirrolidin-1-il]-3-oxopropano-1,2-diol cristalino

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Publication number
BR112017003010A2
BR112017003010A2 BR112017003010A BR112017003010A BR112017003010A2 BR 112017003010 A2 BR112017003010 A2 BR 112017003010A2 BR 112017003010 A BR112017003010 A BR 112017003010A BR 112017003010 A BR112017003010 A BR 112017003010A BR 112017003010 A2 BR112017003010 A2 BR 112017003010A2
Authority
BR
Brazil
Prior art keywords
oxopropane
methylpyrrolidin
azetidin
methylpyridin
oxy
Prior art date
Application number
BR112017003010A
Other languages
English (en)
Inventor
Huang Ping
Dietrich Ribe Seth
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR112017003010A2 publication Critical patent/BR112017003010A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

a presente invenção refere-se a (2s)-3-[(3s,4s)-3-[(1r)-1-hidroxietil]-4-(4-metoxi-3-{[1-(5-metilpiridin-2-il)azetidin-3-il]oxi}fenil)-3-metilpirrolidin-1-il]-3-oxopropano-1,2-diol cristalino, e composições farmacêuticas do mesmo. a presente invenção refere-se adicionalmente a métodos de uso deste composto para tratar bexiga hiperativa.
BR112017003010A 2014-09-04 2015-08-28 (2s)-3-[(3s,4s)-3-[(1r)-1-hidroxietil]-4-(4-metoxi-3-{[1-(5-metilpiridin-2-il)azetidin-3-il]oxi}fenil)-3-metilpirrolidin-1-il]-3-oxopropano-1,2-diol cristalino BR112017003010A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2014/085925 WO2016033776A1 (en) 2014-09-04 2014-09-04 Crystalline (2s) -3- [ (3s, 4s) -3- [ (1r) -1-hydroxyethyl] -4- (4-methoxy-3- { [1- (5-methylpyridin-2-yl) azetidin-3-yl] oxy} phenyl) -3-methylpyrrolidin-1-yl] -3-oxopropane-1, 2-diol
PCT/US2015/047415 WO2016036596A1 (en) 2014-09-04 2015-08-28 Crystalline (2s)-3-[(3s,4s)-3-[(1r)-1-hydroxyethyl]-4-(4-methoxy-3-{[1-(5-methylpyridin-2-yl)azetidin-3-yl]oxy}phenyl) -3-methylpyrrolidin-1-yl]-3-oxopropane-1,2-diol

Publications (1)

Publication Number Publication Date
BR112017003010A2 true BR112017003010A2 (pt) 2017-12-12

Family

ID=54073019

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017003010A BR112017003010A2 (pt) 2014-09-04 2015-08-28 (2s)-3-[(3s,4s)-3-[(1r)-1-hidroxietil]-4-(4-metoxi-3-{[1-(5-metilpiridin-2-il)azetidin-3-il]oxi}fenil)-3-metilpirrolidin-1-il]-3-oxopropano-1,2-diol cristalino

Country Status (26)

Country Link
US (1) US10065942B2 (pt)
EP (1) EP3189044B1 (pt)
JP (1) JP6364545B2 (pt)
KR (1) KR20170038884A (pt)
CN (1) CN107001327B (pt)
AP (1) AP2017009774A0 (pt)
AU (1) AU2015312229B2 (pt)
BR (1) BR112017003010A2 (pt)
CA (1) CA2956517A1 (pt)
CL (1) CL2017000467A1 (pt)
CO (1) CO2017001097A2 (pt)
CR (1) CR20170051A (pt)
DO (1) DOP2017000037A (pt)
EA (1) EA031089B1 (pt)
EC (1) ECSP17013015A (pt)
ES (1) ES2688167T3 (pt)
IL (1) IL250356A0 (pt)
MA (1) MA40606A (pt)
MX (1) MX2017002688A (pt)
NZ (1) NZ728359A (pt)
PE (1) PE20170442A1 (pt)
PH (1) PH12017500400A1 (pt)
SG (1) SG11201701608RA (pt)
TN (1) TN2017000045A1 (pt)
TW (1) TWI570119B (pt)
WO (2) WO2016033776A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR101696A1 (es) * 2014-09-12 2017-01-04 Lilly Co Eli Compuestos de azetidiniloxifenilpirrolidina
WO2021036953A1 (zh) * 2019-08-23 2021-03-04 湖北生物医药产业技术研究院有限公司 苯基吡咯烷类化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258833B1 (en) * 1999-12-23 2001-07-10 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
CN101166737A (zh) * 2004-10-20 2008-04-23 记忆药物公司 磷酸二酯酶4抑制剂
CA2623657A1 (en) 2005-09-29 2007-04-12 Bayer Healthcare Ag Pde inhibitors and combinations thereof for the treatment of urological disorders
TW201206440A (en) * 2010-04-28 2012-02-16 Astellas Pharma Inc Prophylactic or therapeutic agent for diseases associated with pains in urinary organs
TWI617553B (zh) * 2013-03-13 2018-03-11 美國禮來大藥廠 吖丁啶基氧苯基吡咯啶化合物

Also Published As

Publication number Publication date
AU2015312229B2 (en) 2017-11-16
ECSP17013015A (es) 2018-03-31
EA031089B1 (ru) 2018-11-30
JP2017525747A (ja) 2017-09-07
CN107001327B (zh) 2022-09-02
IL250356A0 (en) 2017-03-30
MX2017002688A (es) 2017-05-30
US10065942B2 (en) 2018-09-04
CO2017001097A2 (es) 2017-04-28
NZ728359A (en) 2018-08-31
CL2017000467A1 (es) 2017-10-20
TWI570119B (zh) 2017-02-11
US20170233373A1 (en) 2017-08-17
WO2016036596A1 (en) 2016-03-10
PE20170442A1 (es) 2017-04-26
SG11201701608RA (en) 2017-03-30
CR20170051A (es) 2017-04-26
TN2017000045A1 (en) 2018-07-04
AU2015312229A1 (en) 2017-02-02
EP3189044A1 (en) 2017-07-12
EP3189044B1 (en) 2018-08-01
ES2688167T3 (es) 2018-10-31
DOP2017000037A (es) 2017-02-28
CN107001327A (zh) 2017-08-01
TW201619149A (zh) 2016-06-01
CA2956517A1 (en) 2016-03-10
JP6364545B2 (ja) 2018-07-25
PH12017500400A1 (en) 2017-07-17
MA40606A (fr) 2016-03-10
EA201790143A1 (ru) 2017-06-30
WO2016033776A1 (en) 2016-03-10
KR20170038884A (ko) 2017-04-07
AP2017009774A0 (en) 2017-02-28

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Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]