BR112017001498A2 - receptores de antígeno quiméricos bcma - Google Patents

receptores de antígeno quiméricos bcma

Info

Publication number
BR112017001498A2
BR112017001498A2 BR112017001498-0A BR112017001498A BR112017001498A2 BR 112017001498 A2 BR112017001498 A2 BR 112017001498A2 BR 112017001498 A BR112017001498 A BR 112017001498A BR 112017001498 A2 BR112017001498 A2 BR 112017001498A2
Authority
BR
Brazil
Prior art keywords
chimeric antigen
antigen receptors
bcma chimeric
bcma
cell
Prior art date
Application number
BR112017001498-0A
Other languages
English (en)
Other versions
BR112017001498B1 (pt
Inventor
Morgan Richard
friedman Kevin
Original Assignee
Bluebird Bio, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bluebird Bio, Inc. filed Critical Bluebird Bio, Inc.
Publication of BR112017001498A2 publication Critical patent/BR112017001498A2/pt
Publication of BR112017001498B1 publication Critical patent/BR112017001498B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • C07K—PEPTIDES
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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Abstract

a invenção proporciona composições melhoradas para terapias de células t adotivas para condições relacionadas às células b.
BR112017001498-0A 2014-07-24 2015-07-23 Receptor de antígeno quimérico (car) anti-bcma, polinucleotídeo que codifica o dito car, vetor, composição e uso da mesma para tratar uma condição relacionada à célula b BR112017001498B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462028664P 2014-07-24 2014-07-24
US62/028.664 2014-07-24
US201462044103P 2014-08-29 2014-08-29
US62/044.103 2014-08-29
US201562152575P 2015-04-24 2015-04-24
US62/152.575 2015-04-24
PCT/US2015/041722 WO2016014789A2 (en) 2014-07-24 2015-07-23 Bcma chimeric antigen receptors

Publications (2)

Publication Number Publication Date
BR112017001498A2 true BR112017001498A2 (pt) 2018-02-20
BR112017001498B1 BR112017001498B1 (pt) 2024-03-19

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Publication number Publication date
JP2017522882A (ja) 2017-08-17
KR102523934B1 (ko) 2023-04-20
SG10201900455YA (en) 2019-02-27
WO2016014789A3 (en) 2016-03-17
RU2747457C2 (ru) 2021-05-05
SG11201700492SA (en) 2017-02-27
IL250202A0 (en) 2017-03-30
JP6706244B2 (ja) 2020-06-03
EP3172231A4 (en) 2018-01-10
EP3172231A2 (en) 2017-05-31
ES2878449T3 (es) 2021-11-18
US20200079864A1 (en) 2020-03-12
ZA201700730B (en) 2021-06-30
WO2016014789A2 (en) 2016-01-28
EP3172231B1 (en) 2021-05-05
CA2956002A1 (en) 2016-01-28
MX2017001079A (es) 2017-09-12
KR20170036021A (ko) 2017-03-31
US20170226216A1 (en) 2017-08-10
CN106795217A (zh) 2017-05-31
AU2015292590A1 (en) 2017-02-16
RU2017106025A (ru) 2018-08-30
CN106795217B (zh) 2021-08-06
AU2015292590B2 (en) 2020-01-16
IL250202B (en) 2020-09-30
RU2017106025A3 (pt) 2019-02-15
CA2956002C (en) 2023-06-27

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