BR112016006584A2 - composições e método para desestabilizar, alterar, e dispersar biofilmes - Google Patents

composições e método para desestabilizar, alterar, e dispersar biofilmes

Info

Publication number
BR112016006584A2
BR112016006584A2 BR112016006584A BR112016006584A BR112016006584A2 BR 112016006584 A2 BR112016006584 A2 BR 112016006584A2 BR 112016006584 A BR112016006584 A BR 112016006584A BR 112016006584 A BR112016006584 A BR 112016006584A BR 112016006584 A2 BR112016006584 A2 BR 112016006584A2
Authority
BR
Brazil
Prior art keywords
biofilms
altering
destabilizing
compositions
dispersing
Prior art date
Application number
BR112016006584A
Other languages
English (en)
Other versions
BR112016006584B1 (pt
Inventor
Rickard Alexander
S Samarian Derek
Kolderman Ethan
Jakubovics Nick
Original Assignee
Univ Michigan Regents
Univ Newcastle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52744423&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112016006584(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Michigan Regents, Univ Newcastle filed Critical Univ Michigan Regents
Publication of BR112016006584A2 publication Critical patent/BR112016006584A2/pt
Publication of BR112016006584B1 publication Critical patent/BR112016006584B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/14—Streptococcus; Staphylococcus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Abstract

resumo “composições e método para desestabilizar, alterar, e dispersar biofilmes” a presente divulgação refere-se a composições e métodos para desestabilizar biofilmes, alterar a estrutura 3d do biofilme, e dispersar biofilmes, a fim de potencializar a remoção de célula do biofilme e/ou sensibilidade a outros agentes (por exemplo, tratamentos ambientais ou coaplicados). em particular, a presente divulgação se refere ao uso de l-arginina na remoção e/ou sensibilização (por exemplo, aos antimicrobianos) de micro-organismos em aplicações médicas, industriais, domésticas, ou ambientais, bem como o tratamento de infecções bacterianas (por exemplo, em biofilmes).
BR112016006584-0A 2013-09-24 2014-09-24 Uso de l-arginina e método para desestabilizar, alterar, e dispersar biofilmes BR112016006584B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361881762P 2013-09-24 2013-09-24
US61/881.762 2013-09-24
US201461972920P 2014-03-31 2014-03-31
US61/972.920 2014-03-31
PCT/US2014/057235 WO2015048146A1 (en) 2013-09-24 2014-09-24 Compositions and method for destabilizing, altering, and dispersing biofilms

Publications (2)

Publication Number Publication Date
BR112016006584A2 true BR112016006584A2 (pt) 2017-08-01
BR112016006584B1 BR112016006584B1 (pt) 2022-11-29

Family

ID=52744423

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016006584-0A BR112016006584B1 (pt) 2013-09-24 2014-09-24 Uso de l-arginina e método para desestabilizar, alterar, e dispersar biofilmes

Country Status (11)

Country Link
US (2) US20160235698A1 (pt)
EP (3) EP3150715B1 (pt)
CN (3) CN110129352A (pt)
AU (5) AU2014326756B2 (pt)
BR (1) BR112016006584B1 (pt)
DK (1) DK3049073T3 (pt)
ES (1) ES2847388T3 (pt)
MX (1) MX2016003791A (pt)
PL (1) PL3049073T3 (pt)
WO (1) WO2015048146A1 (pt)
ZA (1) ZA201602797B (pt)

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Publication number Priority date Publication date Assignee Title
DE112008001301T5 (de) 2007-05-14 2010-04-29 Reserach Foundation Of State University Of New York Induktion einer physiologischen Dispersions-Antwort in Bakterien-Zellen in einem Biofilm
MX2016003791A (es) 2013-09-24 2017-01-20 Univ Michigan Regents Composiciones y método para desestabilizar, alterar y dispersar biopelículas.
US9795579B1 (en) * 2017-04-24 2017-10-24 Knoze Jr. Corporation Oral microbiota promoting method
US20240016945A1 (en) * 2018-02-21 2024-01-18 The Board Of Trustees Of The Leland Stanford Junior University Composition and method for new antimicrobial agents with secondary mode of action provided by conjugation of an antimicrobial to a guanidinium-rich molecular transporter
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US10927397B2 (en) 2018-10-16 2021-02-23 Sterilex, Llc Compositions, devices and methods for detecting biofilms
CN113271918A (zh) * 2018-12-26 2021-08-17 高露洁-棕榄公司 使用精氨酸降低病原性细菌
US20210196598A1 (en) * 2018-12-26 2021-07-01 Colgate-Palmolive Company Specific Co-Aggregation Inhibition by Arginine
BR112021011600A2 (pt) * 2018-12-26 2021-08-31 Colgate-Palmolive Company Métodos de mudança de biofilme na cavidade oral do patogênico ao biofilme saudável
CN110583697B (zh) * 2019-09-20 2021-04-06 浙江工商大学 去除铜绿假单胞菌生物膜用的高效化学生物制剂及其应用
EP4054517A1 (en) * 2019-11-08 2022-09-14 Colgate-Palmolive Company Methods of modifying biofilm
CN111299267B (zh) * 2020-02-12 2021-10-22 上海交通大学 一种基于群感效应的供水管网生物膜控制方法及其应用
WO2023114550A2 (en) * 2021-12-19 2023-06-22 The Trustees Of Columbia University In The City Of New York Engineering bacteria swarm patterns for spatiotemporal information encoding

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US4539234A (en) 1981-05-27 1985-09-03 Unitika Ltd. Urethral catheter capable of preventing urinary tract infection and process for producing the same
EP1159951A1 (en) * 2000-06-02 2001-12-05 Societe Des Produits Nestle S.A. Use of exogenous lactic bacteria strain against Actinomyces naeslundii-related diseases
WO2000066616A1 (en) * 1999-05-03 2000-11-09 Advanced Research & Technology Institute, Inc. METHODS AND COMPOSITIONS FOR CONTROLLING DENTAL CARIES, AND RECOMBINANT SmaA POLYPEPTIDES USEFUL FOR SAME
AU2001286741A1 (en) * 2000-08-25 2002-03-04 Trustees Of Tufts College Methods and compositions for potentiating antibiotic action against persistent/tolerant pathogenic microorganisms
US20100021942A1 (en) * 2008-07-25 2010-01-28 Paul Freemont Cell-free expression system for the detection of bacterial biofilms
US20110318282A1 (en) * 2008-12-22 2011-12-29 Micropure, Inc. Composition and method for reducing demineralization of teeth
WO2011162756A1 (en) * 2010-06-23 2011-12-29 Colgate-Palmolive Company Therapeutic oral composition
MX350073B (es) 2010-10-27 2017-08-25 Colgate Palmolive Co Composicion del cuidado oral que comprende arginina y carbonato de calcio.
US9717929B2 (en) 2010-12-07 2017-08-01 Colgate-Palmolive Company Dentifrice compositions containing calcium silicate and a basic amino acid
CN104010653B (zh) * 2011-10-31 2019-01-01 凯恩生物科技有限公司 用于预防并治疗口腔疾病的组合物和方法
US9561168B2 (en) * 2011-12-15 2017-02-07 Colgate-Palmolive Company Oral care compositions
MX2016003791A (es) 2013-09-24 2017-01-20 Univ Michigan Regents Composiciones y método para desestabilizar, alterar y dispersar biopelículas.

Also Published As

Publication number Publication date
DK3049073T3 (da) 2021-02-01
AU2019271937B2 (en) 2021-01-28
AU2016202002B2 (en) 2017-10-12
US20160235698A1 (en) 2016-08-18
EP3049073B1 (en) 2020-11-04
AU2022271381A1 (en) 2022-12-15
EP3150715A1 (en) 2017-04-05
EP3831374A1 (en) 2021-06-09
CN110129352A (zh) 2019-08-16
US10570401B2 (en) 2020-02-25
CN106029062A (zh) 2016-10-12
AU2021202650B2 (en) 2022-09-08
PL3049073T3 (pl) 2021-10-25
EP3150715B1 (en) 2018-11-14
AU2014326756B2 (en) 2019-08-29
EP3049073A4 (en) 2017-03-15
EP3049073A1 (en) 2016-08-03
AU2016202002A1 (en) 2016-04-21
ES2847388T3 (es) 2021-08-03
AU2019271937A1 (en) 2019-12-19
WO2015048146A1 (en) 2015-04-02
CN115177607A (zh) 2022-10-14
BR112016006584B1 (pt) 2022-11-29
ZA201602797B (en) 2018-12-19
MX2016003791A (es) 2017-01-20
AU2014326756A1 (en) 2016-04-07
AU2021202650A1 (en) 2021-05-27
US20160304886A1 (en) 2016-10-20

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/09/2014, OBSERVADAS AS CONDICOES LEGAIS