BR112016005557A2 - novos peptídeos e análogos para uso no tratamento de mucosite oral - Google Patents
novos peptídeos e análogos para uso no tratamento de mucosite oralInfo
- Publication number
- BR112016005557A2 BR112016005557A2 BR112016005557A BR112016005557A BR112016005557A2 BR 112016005557 A2 BR112016005557 A2 BR 112016005557A2 BR 112016005557 A BR112016005557 A BR 112016005557A BR 112016005557 A BR112016005557 A BR 112016005557A BR 112016005557 A2 BR112016005557 A2 BR 112016005557A2
- Authority
- BR
- Brazil
- Prior art keywords
- mucositis
- chemotherapy
- idrs
- models
- induced
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 208000003265 stomatitis Diseases 0.000 title abstract 3
- 206010028116 Mucosal inflammation Diseases 0.000 abstract 4
- 201000010927 Mucositis Diseases 0.000 abstract 4
- 238000002512 chemotherapy Methods 0.000 abstract 3
- 230000005855 radiation Effects 0.000 abstract 2
- 206010064147 Gastrointestinal inflammation Diseases 0.000 abstract 1
- 241001529936 Murinae Species 0.000 abstract 1
- 206010062959 Neutropenic colitis Diseases 0.000 abstract 1
- 206010059482 Neutropenic infection Diseases 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 208000014834 chemotherapy-induced oral mucositis Diseases 0.000 abstract 1
- 230000007123 defense Effects 0.000 abstract 1
- 208000018925 gastrointestinal mucositis Diseases 0.000 abstract 1
- 238000011553 hamster model Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000015788 innate immune response Effects 0.000 abstract 1
- 238000010172 mouse model Methods 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000004044 response Effects 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
resumo novos peptídeos e análogos para uso no tratamento de mucosite oral dados pré-clínicos obtidos em modelos de mucosite induzida por quimioterapia, mucosite induzida por radiação, infecção neutropênica e colite indicam mucosite oral que é uma indicação promissora para peptídeos reguladores de defesa inatos (idr). os resultados de eficácia pré-clínicos obtidos com os idrs em modelos de camundongo e de hamster de mucosite indicam que a dosagem a cada terceiro dia deve ser capaz de cobrir a mucosite "janela" com sete a catorze doses, dependendo da duração da quimioterapia ou a exposição à radiação. idrs também demonstraram eficácia em modelos de camundongo de mucosite gastrintestinal e oral induzida por quimioterapia, consistente com a resposta da resposta imune inata à quimioterapia e/ou dano da radiação. idrs também são eficazes na redução da carga bacteriana e melhoraram a sobrevivência na presença ou na ausência de tratamento com antibiótico em vários modelos de infecção de murino.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361877767P | 2013-09-13 | 2013-09-13 | |
| US61/877,767 | 2013-09-13 | ||
| PCT/US2014/050516 WO2015038264A1 (en) | 2013-09-13 | 2014-08-11 | Novel peptides and analogs for use in the treatment of oral mucositis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112016005557A2 true BR112016005557A2 (pt) | 2017-09-12 |
| BR112016005557B1 BR112016005557B1 (pt) | 2024-01-02 |
Family
ID=52666140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016005557-8A BR112016005557B1 (pt) | 2013-09-13 | 2014-08-11 | Uso de peptídeos e peptídeos isolados |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9850279B2 (pt) |
| EP (1) | EP3044229B1 (pt) |
| JP (2) | JP6645968B2 (pt) |
| KR (3) | KR102483333B1 (pt) |
| CN (1) | CN105722852B (pt) |
| AU (3) | AU2014318247B2 (pt) |
| BR (1) | BR112016005557B1 (pt) |
| CA (1) | CA2923553C (pt) |
| DK (1) | DK3044229T3 (pt) |
| ES (1) | ES2965906T3 (pt) |
| FI (1) | FI3044229T3 (pt) |
| HK (1) | HK1221960A1 (pt) |
| HR (1) | HRP20231652T1 (pt) |
| HU (1) | HUE066502T2 (pt) |
| IL (1) | IL244573B (pt) |
| LT (1) | LT3044229T (pt) |
| MX (1) | MX2016003092A (pt) |
| MY (1) | MY177930A (pt) |
| NZ (2) | NZ718534A (pt) |
| PL (1) | PL3044229T3 (pt) |
| PT (1) | PT3044229T (pt) |
| RU (1) | RU2668963C2 (pt) |
| SG (1) | SG11201601891XA (pt) |
| WO (1) | WO2015038264A1 (pt) |
| ZA (2) | ZA201601967B (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9808438B2 (en) * | 2015-11-09 | 2017-11-07 | Enzychem Lifesciences Corporation | Method for treating mucositis |
| GB201711183D0 (en) | 2017-07-12 | 2017-08-23 | Smith & Nephew | Antimicrobial or wound care materials, devices and uses |
| US20200108098A1 (en) * | 2018-02-23 | 2020-04-09 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Anti-cd83 chimeric antigen receptor expressing t regulatory cells |
| KR102192471B1 (ko) * | 2019-10-18 | 2020-12-17 | 주식회사 인코스팜 | 탈모 완화 및 모발 성장을 촉진시키는 펩타이드 및 이를 포함하는 화장료 조성물 |
| AU2021354766A1 (en) | 2020-09-30 | 2023-05-11 | Biotempt B.V. | Autophagy-inhibiting peptide and organic acid salt thereof addressing issues of vascular permeability |
| CN117858717A (zh) | 2021-08-30 | 2024-04-09 | 联合化学实验室有限公司 | 用于治疗炎症性疾病的蛋白质组合物 |
| CN115944708A (zh) * | 2021-12-28 | 2023-04-11 | 四川好医生攀西药业有限责任公司 | 三肽在制备治疗和/或预防黏膜或皮肤损伤药物中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2701281B2 (ja) * | 1988-01-22 | 1998-01-21 | 吉富製薬株式会社 | ピラゾロピリジン化合物 |
| US20030162706A1 (en) * | 2002-02-08 | 2003-08-28 | The Procter & Gamble Company | Angiogenesis modulating proteins |
| WO2003072061A2 (en) | 2002-02-26 | 2003-09-04 | Sangstat Medical Corporation | Methods and compositions for treating gastrointestinal toxicity induced by cytoablative therapy |
| CN1269837C (zh) | 2002-09-02 | 2006-08-16 | 上海高科联合生物技术研发有限公司 | 一组合成抗菌肽 |
| AU2006299682B2 (en) | 2005-10-04 | 2013-09-05 | Soligenix, Inc. | Novel peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity |
| WO2008143679A2 (en) * | 2006-06-01 | 2008-11-27 | Verenium Corporation | Nucleic acids and proteins and methods for making and using them |
| CN101578368A (zh) * | 2006-10-04 | 2009-11-11 | 伊尼梅克斯制药公司 | 包括通过调节先天免疫治疗和预防感染在内的治疗和预防免疫相关疾病的新型肽 |
| BRPI0717500A2 (pt) * | 2006-10-04 | 2014-03-25 | Inimex Pharmaceuticals Inc | Peptídeos para o tratamento e a prevenção de desordens relacionadas à imunidade, incluindo tratamento e prevenção de infecção por modulação da imunidade inata. |
| CA2745930C (en) * | 2008-12-08 | 2017-05-02 | Soligenix, Inc. | Topically active steroids for use in radiation and chemotherapeutics injury |
| IL225538A0 (en) * | 2009-03-30 | 2013-06-27 | Nestec Sa | Methods for the identification of anti-immune reaction peptides of anti-citrullinates |
| CN102286073B (zh) * | 2011-06-27 | 2013-09-11 | 华中科技大学同济医学院附属同济医院 | 一种与牙釉质表面轴向特异性结合的七肽及其应用 |
| US20150148304A1 (en) * | 2013-10-24 | 2015-05-28 | Soligenix, Inc. | Novel Peptides and Analogs for Use in the Treatment of Macrophage Activation Syndrome |
| KR101742069B1 (ko) * | 2013-10-25 | 2017-05-31 | (주)연우 | 리필이 가능한 압출식 앰플용기 |
-
2014
- 2014-08-11 US US15/021,889 patent/US9850279B2/en active Active
- 2014-08-11 WO PCT/US2014/050516 patent/WO2015038264A1/en active Application Filing
- 2014-08-11 NZ NZ71853414A patent/NZ718534A/en unknown
- 2014-08-11 JP JP2016541974A patent/JP6645968B2/ja active Active
- 2014-08-11 HR HRP20231652TT patent/HRP20231652T1/hr unknown
- 2014-08-11 MX MX2016003092A patent/MX2016003092A/es unknown
- 2014-08-11 KR KR1020217029666A patent/KR102483333B1/ko active IP Right Grant
- 2014-08-11 PL PL14844276.7T patent/PL3044229T3/pl unknown
- 2014-08-11 NZ NZ756128A patent/NZ756128A/en unknown
- 2014-08-11 FI FIEP14844276.7T patent/FI3044229T3/fi active
- 2014-08-11 CA CA2923553A patent/CA2923553C/en active Active
- 2014-08-11 KR KR1020167009699A patent/KR20160058845A/ko not_active Application Discontinuation
- 2014-08-11 KR KR1020217010249A patent/KR102304906B1/ko active IP Right Grant
- 2014-08-11 ES ES14844276T patent/ES2965906T3/es active Active
- 2014-08-11 LT LTEPPCT/US2014/050516T patent/LT3044229T/lt unknown
- 2014-08-11 BR BR112016005557-8A patent/BR112016005557B1/pt active IP Right Grant
- 2014-08-11 PT PT148442767T patent/PT3044229T/pt unknown
- 2014-08-11 HU HUE14844276A patent/HUE066502T2/hu unknown
- 2014-08-11 RU RU2016110153A patent/RU2668963C2/ru active
- 2014-08-11 EP EP14844276.7A patent/EP3044229B1/en active Active
- 2014-08-11 CN CN201480062073.1A patent/CN105722852B/zh active Active
- 2014-08-11 SG SG11201601891XA patent/SG11201601891XA/en unknown
- 2014-08-11 MY MYPI2016000451A patent/MY177930A/en unknown
- 2014-08-11 AU AU2014318247A patent/AU2014318247B2/en active Active
- 2014-08-11 DK DK14844276.7T patent/DK3044229T3/da active
-
2016
- 2016-03-13 IL IL244573A patent/IL244573B/en active IP Right Grant
- 2016-03-22 ZA ZA2016/01967A patent/ZA201601967B/en unknown
- 2016-08-24 HK HK16110061.5A patent/HK1221960A1/zh unknown
-
2017
- 2017-12-20 US US15/848,746 patent/US10253068B2/en active Active
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2018
- 2018-08-13 AU AU2018214160A patent/AU2018214160B2/en active Active
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2019
- 2019-04-11 JP JP2019075940A patent/JP2019142910A/ja active Pending
-
2020
- 2020-05-25 AU AU2020203410A patent/AU2020203410A1/en not_active Abandoned
-
2022
- 2022-08-19 ZA ZA2022/09308A patent/ZA202209308B/en unknown
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/08/2014, OBSERVADAS AS CONDICOES LEGAIS |