BR112016000792A8 - compostos cianotriazol, seu uso, e agente profilático e/ou terapêutico - Google Patents

compostos cianotriazol, seu uso, e agente profilático e/ou terapêutico Download PDF

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BR112016000792A8
BR112016000792A8 BR112016000792A BR112016000792A BR112016000792A8 BR 112016000792 A8 BR112016000792 A8 BR 112016000792A8 BR 112016000792 A BR112016000792 A BR 112016000792A BR 112016000792 A BR112016000792 A BR 112016000792A BR 112016000792 A8 BR112016000792 A8 BR 112016000792A8
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prophylactic
disorders
diseases
salt
citric acid
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BR112016000792A
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BR112016000792B1 (pt
BR112016000792A2 (pt
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Matsumura Chiharu
Tai Kuninori
Itotani Motohiro
Kanemoto Naohide
Matsuda Satoshi
Sato Seiji
Fujita Shigekazu
Fukushima Tae
Okamoto Takashi
Shinohara Toshio
Sakurai Yohji
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Otsuka Pharma Co Ltd
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Publication of BR112016000792A2 publication Critical patent/BR112016000792A2/pt
Publication of BR112016000792A8 publication Critical patent/BR112016000792A8/pt
Publication of BR112016000792B1 publication Critical patent/BR112016000792B1/pt

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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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Abstract

esta invenção refere-se a um composto cianotriazol representado pela fórmula (1): , em que cada um dos símbolos é definido na especificação, ou um seu sal. o composto ou um seu sal estimula a atividade do ciclo do ácido cítrico e/ou melhora a hiperglicemia com menos efeitos se-cundários, e segurança excelente, e portanto, é útil para o tratamento e/ou a prevenção de doenças ou distúrbios nos quais a ativação do ciclo do ácido cítrico e/ou a melhoria de hiperglicemia têm um efeito profilático e/ou terapêutico, por exemplo, diabetes, tolerância diminuída à glicose, resistência à insulina, complicações diabéticas, obesidade, dislipidemia, esteatose hepática, aterosclerose e/ou doença cardiovascular, bem como doenças ou distúrbios que irão beneficiar de estimulação do gasto de energia.
BR112016000792-1A 2013-07-17 2014-07-16 Compostos cianotriazol, seu uso, e agente profilático e/ou terapêutico BR112016000792B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361847268P 2013-07-17 2013-07-17
US61/847,268 2013-07-17
US201361885254P 2013-10-01 2013-10-01
US61/885,254 2013-10-01
US201461928267P 2014-01-16 2014-01-16
US61/928,267 2014-01-16
PCT/JP2014/069501 WO2015008872A1 (en) 2013-07-17 2014-07-16 Cyanotriazole compounds

Publications (3)

Publication Number Publication Date
BR112016000792A2 BR112016000792A2 (pt) 2017-07-25
BR112016000792A8 true BR112016000792A8 (pt) 2020-01-07
BR112016000792B1 BR112016000792B1 (pt) 2023-05-30

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AU2014291142A1 (en) 2016-02-11
CA2917267C (en) 2021-12-28
TW201542534A (zh) 2015-11-16
MY184572A (en) 2021-04-05
CA2917267A1 (en) 2015-01-22
WO2015008872A1 (en) 2015-01-22
KR102377635B1 (ko) 2022-03-24
TWI641595B (zh) 2018-11-21
IL243592A0 (en) 2016-02-29
IL243592B (en) 2022-05-01
AU2014291142B2 (en) 2018-10-11
SG10201800325PA (en) 2018-02-27
US20160229816A1 (en) 2016-08-11
US10626095B2 (en) 2020-04-21
CN105408325B (zh) 2019-10-22
KR20160030995A (ko) 2016-03-21
HK1222658A1 (zh) 2017-07-07
MX2016000654A (es) 2016-05-26
PH12016500085B1 (en) 2016-04-18
SA516370405B1 (ar) 2021-07-26
SG11201600108PA (en) 2016-02-26
EP3022199A1 (en) 2016-05-25
CN105408325A (zh) 2016-03-16
EA201690228A1 (ru) 2016-05-31
ZA201600353B (en) 2022-03-30
JP6503336B2 (ja) 2019-04-17
PH12016500085A1 (en) 2016-04-18
NZ715940A (en) 2021-08-27
JP2016525069A (ja) 2016-08-22
BR112016000792A2 (pt) 2017-07-25
EP4219477A1 (en) 2023-08-02

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