BR112015028650A2 - UM ANTÍGENO ISOLADO PARA LEUCOCIDINA DE S. AUREUS, UM ANTICORPO LIGANTE ESPECÍFICO PARA O ANTÍGENO, E UM COMPLEXO CD11b/CD18 HUMANO PARA UTILIZAÇÃO EM UM MÉTODO ANALÍTICO - Google Patents

UM ANTÍGENO ISOLADO PARA LEUCOCIDINA DE S. AUREUS, UM ANTICORPO LIGANTE ESPECÍFICO PARA O ANTÍGENO, E UM COMPLEXO CD11b/CD18 HUMANO PARA UTILIZAÇÃO EM UM MÉTODO ANALÍTICO

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Publication number
BR112015028650A2
BR112015028650A2 BR112015028650A BR112015028650A BR112015028650A2 BR 112015028650 A2 BR112015028650 A2 BR 112015028650A2 BR 112015028650 A BR112015028650 A BR 112015028650A BR 112015028650 A BR112015028650 A BR 112015028650A BR 112015028650 A2 BR112015028650 A2 BR 112015028650A2
Authority
BR
Brazil
Prior art keywords
antigen
complex
aureus
leukocydin
isolated
Prior art date
Application number
BR112015028650A
Other languages
English (en)
Inventor
Zoltán Magyarics
Eszter Nagy
Adriana Badarau
Harald Rouha
Sophia Zettl
Michael Benjamin Battles
Original Assignee
Arsanis Biosciences Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arsanis Biosciences Gmbh filed Critical Arsanis Biosciences Gmbh
Publication of BR112015028650A2 publication Critical patent/BR112015028650A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

UM ANTÍGENO ISOLADO PARA LEUCOCIDINA DE S. AUREUS, UM ANTICORPO LIGANTE ESPECÍFICO PARA O ANTÍGENO, E UM COMPLEXO CD11B/CD18 HUMANO PARA UTILIZAÇÃO EM UM MÉTODO ANALÍTICO. A presente invenção se refere a um antígeno isolado para leucocidina de Staphylococcus aureus, compreendendo um complexo LukGH, um anticorpo que se liga especificamente ao complexo LukGH, e o complexo CD11b/CD18 humano para utilização em um método de determinação da ligação ou toxicidade da citolisina bicomponente LukGH de Staphylococcus aureus.
BR112015028650A 2013-05-21 2014-05-16 UM ANTÍGENO ISOLADO PARA LEUCOCIDINA DE S. AUREUS, UM ANTICORPO LIGANTE ESPECÍFICO PARA O ANTÍGENO, E UM COMPLEXO CD11b/CD18 HUMANO PARA UTILIZAÇÃO EM UM MÉTODO ANALÍTICO BR112015028650A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13168631 2013-05-21
PCT/EP2014/060123 WO2014187746A2 (en) 2013-05-21 2014-05-16 Generation of highly potent antibodies neutralizing the lukgh (lukab) toxin of staphylococcus aureus

Publications (1)

Publication Number Publication Date
BR112015028650A2 true BR112015028650A2 (pt) 2017-09-19

Family

ID=48470786

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015028650A BR112015028650A2 (pt) 2013-05-21 2014-05-16 UM ANTÍGENO ISOLADO PARA LEUCOCIDINA DE S. AUREUS, UM ANTICORPO LIGANTE ESPECÍFICO PARA O ANTÍGENO, E UM COMPLEXO CD11b/CD18 HUMANO PARA UTILIZAÇÃO EM UM MÉTODO ANALÍTICO

Country Status (11)

Country Link
US (1) US20160108106A1 (pt)
EP (1) EP2999713A2 (pt)
JP (2) JP6560195B2 (pt)
CN (1) CN105473613A (pt)
AU (1) AU2014270598B2 (pt)
BR (1) BR112015028650A2 (pt)
CA (1) CA2913088A1 (pt)
MX (1) MX2015015965A (pt)
RU (1) RU2015154792A (pt)
WO (1) WO2014187746A2 (pt)
ZA (1) ZA201508287B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014336111A1 (en) * 2013-10-17 2016-04-14 Arsanis Biosciences Gmbh Cross-reactive Staphylococcus aureus antibody sequences
RU2016129526A (ru) * 2013-12-19 2018-01-24 Арзанис Байэусайнсис ГмбХ Антитело, выделенная нуклеиновая кислота, выделенный паратоп антитела, выделенный конформационный эпитоп, связывающая молекула, иммуноген, фармацевтический и диагностический препараты, лекарственная форма вакцины, способ лечения больного, подверженного риску или страдающего от инфекции Staphylococcus aureus, способ диагностики обнаружения инфекций Staphylococcus aureus и способ скрининга или анализа для определения связующего
JP2018513168A (ja) 2015-04-17 2018-05-24 アルサニス・バイオサイエンスズ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 抗スタフィロコッカス・アウレウス抗体組み合わせ製剤
US11104724B2 (en) 2016-05-23 2021-08-31 New York University Compositions and methods for antibodies targeting staphylococcal leukotoxins
WO2018165089A1 (en) 2017-03-06 2018-09-13 Vanderbilt University Human monoclonal antibodies to staphylococcus aureus lukab toxin
AU2018285857B2 (en) 2017-06-13 2022-10-06 Abvacc, Inc. Immunogenic compositions comprising Staphylococcus aureus leukocidin lukA and lukB derived polypeptides

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US7117096B2 (en) 2001-04-17 2006-10-03 Abmaxis, Inc. Structure-based selection and affinity maturation of antibody library
AU2003217912A1 (en) 2002-03-01 2003-09-16 Xencor Antibody optimization
WO2007145689A1 (en) * 2006-06-12 2007-12-21 Nabi Biopharmaceuticals Use of alpha-toxin for treating and preventing staphylococcus infections
CN101535811B (zh) * 2006-10-18 2016-05-04 生物梅里埃公司 用于体外诊断产pvl金黄色葡萄球菌的方法
CA2964398C (en) 2007-09-14 2023-03-07 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
SI2445522T1 (sl) * 2009-06-22 2017-10-30 Wyeth Llc Imunogeni sestavki antigenov Staphylococcusa aureusa
US8431687B2 (en) * 2010-05-05 2013-04-30 New York University Staphylococcus aureus leukocidins, therapeutic compositions, and uses thereof
DK3336225T3 (da) 2010-07-16 2020-03-30 Adimab Llc Antistofbiblioteker
PT2668208E (pt) * 2012-04-17 2015-10-12 Arsanis Biosciences Gmbh Anticorpo de staphylococcus aureus de reação cruzada
WO2013165613A1 (en) * 2012-05-02 2013-11-07 New York University Methods of treating and preventing staphylococcus aureus infections and associated conditions

Also Published As

Publication number Publication date
EP2999713A2 (en) 2016-03-30
JP2019142921A (ja) 2019-08-29
US20160108106A1 (en) 2016-04-21
ZA201508287B (en) 2017-01-25
AU2014270598A1 (en) 2015-11-26
WO2014187746A3 (en) 2015-03-12
CA2913088A1 (en) 2014-11-27
JP6560195B2 (ja) 2019-08-14
RU2015154792A (ru) 2017-06-22
AU2014270598B2 (en) 2018-09-20
CN105473613A (zh) 2016-04-06
MX2015015965A (es) 2016-07-11
WO2014187746A2 (en) 2014-11-27
RU2015154792A3 (pt) 2018-03-21
JP2016526033A (ja) 2016-09-01

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2566 DE 2020-03-10