BR112015025832A8 - método, dispositivo e programa de computador para correção de diafonia e instrumento de medida - Google Patents
método, dispositivo e programa de computador para correção de diafonia e instrumento de medida Download PDFInfo
- Publication number
- BR112015025832A8 BR112015025832A8 BR112015025832A BR112015025832A BR112015025832A8 BR 112015025832 A8 BR112015025832 A8 BR 112015025832A8 BR 112015025832 A BR112015025832 A BR 112015025832A BR 112015025832 A BR112015025832 A BR 112015025832A BR 112015025832 A8 BR112015025832 A8 BR 112015025832A8
- Authority
- BR
- Brazil
- Prior art keywords
- crosstalk
- detection wavelength
- intensities
- signal component
- measured
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000004590 computer program Methods 0.000 title 1
- 239000000523 sample Substances 0.000 abstract 5
- 238000001514 detection method Methods 0.000 abstract 4
- 239000012491 analyte Substances 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04Q—SELECTING
- H04Q11/00—Selecting arrangements for multiplex systems
- H04Q11/0001—Selecting arrangements for multiplex systems using optical switching
- H04Q11/0005—Switch and router aspects
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04Q—SELECTING
- H04Q11/00—Selecting arrangements for multiplex systems
- H04Q11/0001—Selecting arrangements for multiplex systems using optical switching
- H04Q11/0003—Details
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/101—Homogeneous assay format, e.g. one pot reaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04Q—SELECTING
- H04Q11/00—Selecting arrangements for multiplex systems
- H04Q11/0001—Selecting arrangements for multiplex systems using optical switching
- H04Q11/0005—Switch and router aspects
- H04Q2011/0037—Operation
- H04Q2011/0049—Crosstalk reduction; Noise; Power budget
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Computer Networks & Wireless Communication (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
resumo patente de invenção: "método e dispositivo para correção de diafonia de intensidades medidas". a presente invenção refere-se um método para correção de diafonia de intensidades medidas em faixas de comprimento de onda de detecção mutuamente separadas. cada faixa de comprimento de onda de detecção se refere a uma das populações de sondas específicas de analitos contidas por uma amostra a ser analisada. cada população de sondas é capaz de emitir um primeiro componente de sinal e um segundo componente de sinal, cujos espectros apresentam máximos em diferentes comprimentos de onda, e pelo menos o primeiro componente de sinal é dependente da presença de analito detectável com essa população de sondas. as intensidades de diafonia corrigidas são computadas com base em: a) as intensidades medidas nas faixas de comprimento de onda de detecção; b) um valor indicativo da intensidade ocorrendo em uma faixa de comprimento de onda auxiliar, fora das faixas de comprimento de onda de detecção, e provocada, pelo menos parcialmente, pelos segundos componentes de sinais; e c) parâmetros de diafonia predeterminados. por exemplo, em conjunto com os ensaios baseados em fret, a dependência de um sinal de fundo no percentual de sondas hibridizadas pode ser considerada na correção de diafonia.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361811847P | 2013-04-15 | 2013-04-15 | |
FI20135367 | 2013-04-15 | ||
US61/811,847 | 2013-04-15 | ||
FI20135367 | 2013-04-15 | ||
PCT/FI2014/050246 WO2014170537A1 (en) | 2013-04-15 | 2014-04-08 | A method and a device for cross-talk correction of measured intensities |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112015025832A2 BR112015025832A2 (pt) | 2017-07-25 |
BR112015025832A8 true BR112015025832A8 (pt) | 2019-12-24 |
BR112015025832B1 BR112015025832B1 (pt) | 2022-03-15 |
Family
ID=51730861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015025832-8A BR112015025832B1 (pt) | 2013-04-15 | 2014-04-08 | Método e dispositivo para correção de diafonia e instrumento de medida |
Country Status (6)
Country | Link |
---|---|
US (1) | US9736555B2 (pt) |
EP (1) | EP2986737A1 (pt) |
CN (1) | CN105324493B (pt) |
BR (1) | BR112015025832B1 (pt) |
TW (1) | TWI611174B (pt) |
WO (1) | WO2014170537A1 (pt) |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI963989A (fi) | 1996-10-04 | 1998-04-05 | Wallac Oy | Homogeenisiä määritysmenetelmiä, jotka perustuvat luminesenssienergiasiirtoon |
US7209836B1 (en) * | 1999-07-16 | 2007-04-24 | Perkinelmer Las, Inc. | Method and system for automatically creating crosstalk-corrected data of a microarray |
EP1389956B1 (en) | 2001-04-25 | 2012-10-31 | Amnis Corporation | Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging |
EP1288308A1 (en) | 2001-08-28 | 2003-03-05 | Roche Diagnostics GmbH | A method for the determination of multiple analytes |
BRPI0414987A (pt) * | 2003-10-01 | 2006-11-21 | Wallac Oy | ensaio aperfeiçoado homogêneo de transferência de energia com resolução no tempo |
US20060147954A1 (en) | 2004-10-19 | 2006-07-06 | Wallac Oy | Novel probe and its use in bioaffinity assays |
US10365213B2 (en) * | 2008-06-11 | 2019-07-30 | Capitalbio Corporation | Reliable fluorescence correction method for two-color measurement fluorescence system |
FI20095302A0 (fi) * | 2009-03-24 | 2009-03-24 | Arctic Partners Oy Ab | Luminesenssimääritysmenetelmä |
US8435738B2 (en) * | 2011-09-25 | 2013-05-07 | Theranos, Inc. | Systems and methods for multi-analysis |
-
2014
- 2014-04-08 CN CN201480033905.7A patent/CN105324493B/zh active Active
- 2014-04-08 EP EP14721911.7A patent/EP2986737A1/en not_active Withdrawn
- 2014-04-08 WO PCT/FI2014/050246 patent/WO2014170537A1/en active Application Filing
- 2014-04-08 TW TW103112840A patent/TWI611174B/zh active
- 2014-04-08 BR BR112015025832-8A patent/BR112015025832B1/pt not_active IP Right Cessation
- 2014-04-08 US US14/784,768 patent/US9736555B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
BR112015025832B1 (pt) | 2022-03-15 |
WO2014170537A1 (en) | 2014-10-23 |
US20160066072A1 (en) | 2016-03-03 |
CN105324493A (zh) | 2016-02-10 |
EP2986737A1 (en) | 2016-02-24 |
BR112015025832A2 (pt) | 2017-07-25 |
US9736555B2 (en) | 2017-08-15 |
CN105324493B (zh) | 2018-02-23 |
TW201447275A (zh) | 2014-12-16 |
TWI611174B (zh) | 2018-01-11 |
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/04/2014, OBSERVADAS AS CONDICOES LEGAIS. |
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B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
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B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2769 DE 30-01-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |